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N-(2-Aminophenyl)-4-([[4-(pyridin-3-yl)pyrimidin-2-yl]amino]methyl)benzamide

N-(2-Aminophenyl)-4-([[4-(pyridin-3-yl)pyrimidin-2-yl]amino]methyl)benzamide structure

CAS No.: 726169-73-9

Chemical Name:: N-(2-Aminophenyl)-4-([[4-(pyridin-3-yl)pyrimidin-2-yl]amino]methyl)benzamide

Synonyms: Mocetinostat;MGCD0103;MG0103;CS-1929;Mocetinostat, >=98%;CD0103) Mocetinostat;MGCD0103(Mocetinostat);Mocetinostat (MGCD0103);Mocetinostat (MGCD0103,MG0103);MGCD0103; MGCD 0103; MGCD-0103

CBNumber:: CB42484945

Molecular Formula:: C23H20N6O

Molecular Weight:: 396.44

MDL Number:: MFCD10565970

MOL File:: 726169-73-9.mol

Last updated:2023-05-18 11:31:10

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N-(2-Aminophenyl)-4-([[4-(pyridin-3-yl)pyrimidin-2-yl]amino]methyl)benzamide Properties

Melting point	>170oC (dec.)
Density	1.340±0.06 g/cm3(Predicted)
storage temp.	RT
solubility	Soluble in DMSO (up to 25 mg/ml)
pka	13.13±0.70(Predicted)
form	solid
color	Off-white
Stability	Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
NCI Dictionary of Cancer Terms	MGCD0103; mocetinostat
FDA UNII	A6GWB8T96J
NCI Drug Dictionary	mocetinostat

N-(2-Aminophenyl)-4-([[4-(pyridin-3-yl)pyrimidin-2-yl]amino]methyl)benzamide price More Price(37)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	18287	Mocetinostat ≥98%	726169-73-9	1mg	$44	2024-03-01	Buy
Cayman Chemical	18287	Mocetinostat ≥98%	726169-73-9	5mg	$109	2024-03-01	Buy
Cayman Chemical	18287	Mocetinostat ≥98%	726169-73-9	10mg	$172	2024-03-01	Buy
Cayman Chemical	18287	Mocetinostat ≥98%	726169-73-9	25mg	$374	2024-03-01	Buy
Usbiological	474140	Mocetinostat	726169-73-9	100mg	$1380	2021-12-16	Buy

Product number	Packaging	Price	Buy
18287	1mg	$44	Buy
18287	5mg	$109	Buy
18287	10mg	$172	Buy
18287	25mg	$374	Buy
474140	100mg	$1380	Buy

N-(2-Aminophenyl)-4-([[4-(pyridin-3-yl)pyrimidin-2-yl]amino]methyl)benzamide Chemical Properties,Uses,Production

Description

Mocetinostat (726169-73-9) is a class I, isoform-selective HDAC inhibitor, IC50s=0.15, 0.29, 1.66 and 0.59 μM for HDAC1, 2, 3 and 11 respectively.1 Induces hyperacetylation of histones, induces expression of the tumor suppressor p21WAF1 and inhibits proliferation of human cancer cells.2 Mocetinostat displays antifibrotic effects in ischemic heart failure.3 Attenuates the development of hypersensitivity in models of neuropathic pain.4 Active in vivo.5

Uses

Mocetinostat is a multi-targeted histone deacetylase inhibitor used in cancer therapy. Mocetinostat is undergoing clinical trials for the treatment of various cancers including follicular lymphoma, Hodgkin’s lymphoma and acute myelogenous leukemia.

Definition

ChEBI: N-(2-aminophenyl)-4-[[[4-(3-pyridinyl)-2-pyrimidinyl]amino]methyl]benzamide is a member of benzamides.

target

HDAC1

References

1) Zhou et al. (2008), Discovery of N-(2-aminophenyl)-4-[(4-pyridin-3-ulpyrimidin-2-ylamino)methyl]benzamide (MGCD0103), an orally active histone deacetylase inhibitor; J. Med. Chem., 51 4072 2) Raeppel et al. (2009), SAR and biological evaluation of analogues of a small molecule histone deacetylase inhibitor N-(2-aminophenyl)-4((4-(pyridine-3-yl)pyrimidin-2-ylamino)methyl)benzamide (MGCD0103); Bioorg. Med. Chem. Lett., 19 644 3) Nural-Guvener et al. (2015), Anti-Fibrotic Effects of Class I HDAC Inhibitor, Mocetinostat is Associated with IL-6/Stat3 Signaling in Ischemic Heart Failure; Int. J. Mol. Sci., 16 11482 4) Denk et al. (2013), HDAC inhibitors attenuate the development of hypersensitivity in models of neuropathic pain; Pain, 154 1668 5) Bonfils et al. (2008), Evaluation of the pharmacodynamics effects of MGCD0103 from preclinical models to human using a novel HDAC enzyme assay; Clin. Cancer Res., 14 3441

N-(2-Aminophenyl)-4-([[4-(pyridin-3-yl)pyrimidin-2-yl]amino]methyl)benzamide synthesis

Synthesis of N-(2-Aminophenyl)-4-([[4-(pyridin-3-yl)pyrimidin-2-yl]amino]methyl)benzamide from 4-({[4-(Pyridin-3-yl)pyrimidin-2-yl]amino}methyl)benzoic acid and o-Phenylenediamine

N-(2-Aminophenyl)-4-([[4-(pyridin-3-yl)pyrimidin-2-yl]amino]methyl)benzamide Preparation Products And Raw materials

Raw materials

Methyl 4-((4-(pyridin-3-yl)pyriMidin-2-ylaMino)Methyl)benzoate Methyl 4-(guanidinoMethyl)benzoate 4-({[4-(Pyridin-3-yl)pyrimidin-2-yl]amino}methyl)benzoic acid 3-Acetylpyridine o-Phenylenediamine

Preparation Products

N-(2-Aminophenyl)-4-([[4-(pyridin-3-yl)pyrimidin-2-yl]amino]methyl)benzamide Suppliers

Global( 146)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	sales@capotchem.com	China	29797	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28180	58
Chongqing Chemdad Co., Ltd	+86-023-61398051 +8613650506873	sales@chemdad.com	China	39916	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49390	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	29220	58
Hefei Hirisun Pharmatech Co., Ltd	+8615056975894	shawn@hirisunpharm.com	CHINA	9923	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10523	58

Supplier	Advantage
Capot Chemical Co.,Ltd.	60
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Hubei Jusheng Technology Co.,Ltd.	58
Chongqing Chemdad Co., Ltd	58
CONIER CHEM AND PHARMA LIMITED	58
TargetMol Chemicals Inc.	58
Dideu Industries Group Limited	58
Hefei Hirisun Pharmatech Co., Ltd	58
Zhejiang J&C Biological Technology Co.,Limited	58

View Lastest Price from N-(2-Aminophenyl)-4-([[4-(pyridin-3-yl)pyrimidin-2-yl]amino]methyl)benzamide manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2019-07-06	N-(2-Aminophenyl)-4-([[4-(pyridin-3-yl)pyrimidin-2-yl]amino]methyl)benzamide 726169-73-9	US $1.00 / KG	1G	98%	100KG	Career Henan Chemical Co

N-(2-Aminophenyl)-4-([[4-(pyridin-3-yl)pyrimidin-2-yl]amino]methyl)benzamide
726169-73-9
US $1.00 / KG
98%
Career Henan Chemical Co

N-(2-Aminophenyl)-4-([[4-(pyridin-3-yl)pyrimidin-2-yl]amino]methyl)benzamide Spectrum

N-(2-Aminophenyl)-4-([[4-(pyridin-3-yl)pyrimidin-2-yl]amino]methyl)benzamide(726169-73-9)MS

726169-73-9(N-(2-Aminophenyl)-4-([[4-(pyridin-3-yl)pyrimidin-2-yl]amino]methyl)benzamide)Related Search:

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Entinostat

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MGCD0103(Mocetinostat) MG0103 Mocetinostat (MGCD0103,MG0103) N-(2-Aminophenyl)-4-([[4-(pyridin-3-yl)pyrimidin-2-yl]amino]methyl)benzamide Mocetinostat (MGCD0103) N-(2-Aminophenyl)-4-([[4-(pyridin-3-yl)pyrimidin-2-yl]amino]methyl)benzamide Mocetinostat (MGCD0103) Mocetinostat, >=98% N-(2-Aminophenyl)-4-[[[4-(3-pyridyl)pyrimidin-2-yl]amino]methyl]benzamide MGCD0103;MGCD 0103;MGCD-0103;MG0103 MGCD0103; MGCD 0103; MGCD-0103 CS-1929 CD0103) Mocetinostat Benzamide, N-(2-aminophenyl)-4-[[[4-(3-pyridinyl)-2-pyrimidinyl]amino]methyl]- N-(2-Aminophenyl)-4-([[4-(pyridin-3-yl)pyrimidin-2-yl]amino]methyl)benzamide USP/EP/BP Mocetinostat MGCD0103 726169-73-9 C23H20ON6 Inhibitor Inhibitors API