ChemicalBook >> CAS DataBase List >>Z-Vad-fmk, non-methylated

Z-Vad-fmk, non-methylated

Z-Vad-fmk, non-methylated structure

CAS No.: 161401-82-7

Chemical Name:: Z-Vad-fmk, non-methylated

Synonyms: Z-VAD;abs817872;Z-VAD-FMK, Free Acid;Z-VAD-FMK, 10 mM in DMSO;Z-VAD-FMK (Caspase Inhibitor VI);Z-VAD(OH)-FMK (Caspase Inhibitor VI);Z-VAL-ALA-ASP-(OH)-FLUOROMETHYL KETONE;Caspase Inhibitor VI - CAS 161401-82-7 - Calbiochem;Carbobenzyloxy-Val-Ala-Asp-alpha-fluoromethylketone;inhibit,Inhibitor,ZVADFMK,Hela,Z VAD FMK,Caspase,Antiapoptosis,cells,pan-caspase

CBNumber:: CB42497499

Molecular Formula:: C21H28FN3O7

Molecular Weight:: 453.46

MDL Number:

MOL File:: 161401-82-7.mol

MSDS File:: SDS

Last updated:2025-05-27 21:43:27

Request For Quotation

Z-Vad-fmk, non-methylated Properties

Boiling point	758.0±60.0 °C(Predicted)
Density	1.260±0.06 g/cm3(Predicted)
storage temp.	-20°C
solubility	DMSO:5.0(Max Conc. mg/mL);11.0(Max Conc. mM)
pka	3.91±0.19(Predicted)
form	Off-white solid
color	White to light yellow
UNSPSC Code	12352209
NACRES	NA.77

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P305+P351+P338

Z-Vad-fmk, non-methylated price More Price(12)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	219007	Caspase Inhibitor VI - CAS 161401-82-7 - Calbiochem Z-VAD-FMK, CAS 161401-82-7, is an irreversible pan caspase inhibitor. Does not require pretreatment with esterase for in vitro studies.	161401-82-7	250μg	$113	2024-03-01	Buy
Sigma-Aldrich	219007	Caspase Inhibitor VI - CAS 161401-82-7 - Calbiochem Z-VAD-FMK, CAS 161401-82-7, is an irreversible pan caspase inhibitor. Does not require pretreatment with esterase for in vitro studies.	161401-82-7	1mg	$303	2024-03-01	Buy
Cayman Chemical	14467	Z-VAD(OH)-FMK ≥95%	161401-82-7	500μg	$73	2024-03-01	Buy
Cayman Chemical	14467	Z-VAD(OH)-FMK ≥95%	161401-82-7	1mg	$131	2024-03-01	Buy
Cayman Chemical	14467	Z-VAD(OH)-FMK ≥95%	161401-82-7	5mg	$380	2024-03-01	Buy

Product number	Packaging	Price	Buy
219007	250μg	$113	Buy
219007	1mg	$303	Buy
14467	500μg	$73	Buy
14467	1mg	$131	Buy
14467	5mg	$380	Buy

Z-Vad-fmk, non-methylated Chemical Properties,Uses,Production

Description

Z-VAD(OH)-FMK is an irreversible tripeptide inhibitor of all caspases. This non-methylated form is useful in studies involving recombinant, isolated, or purified enzymes. Unlike the methylated form, Z-VAD(OMe)-FMK , this compound does not require pretreatment with esterases prior to in vitro use.

Uses

Z-VAD-FMK (Z-VAD(OH)-FMK) is a well-know pan caspase inhibitor, which does not inhibit ubiquitin carboxy-terminal hydrolase L1 (UCHL1) activity even at concentrations as high as 440 μM[1].

General Description

An irreversible general caspase inhibitor. Useful for studies involving recombinant, isolated, and purified caspase enzymes. Unlike Caspase Inhibitor I (Cat. No. 627610), this inhibitor does not require pretreatment with esterase for in vitro studies. A 10 mM (1 mg/221 μl) solution of Caspase Inhibitor VI (Cat. No. 219011) in DMSO is also available.

Biochem/physiol Actions

Product does not compete with ATP.

IC 50

Caspase

References

[1] Davies CW, et al. The co-crystal structure of ubiquitin carboxy-terminal hydrolase L1 (UCHL1) with a tripeptide fluoromethyl ketone (Z-VAE(OMe)-FMK). Bioorg Med Chem Lett. 2012 Jun 15;22(12):3900-4. DOI:10.1016/j.bmcl.2012.04.124
[2] Liu HR, et al. Antiproliferative activity of the total saponin of Solanum lyratum Thunb in Hela cells by inducing apoptosis. Pharmazie. 2008 Nov;63(11):836-42. PMID:19069247

Z-Vad-fmk, non-methylated Preparation Products And Raw materials

Raw materials

Preparation Products

Z-Vad-fmk, non-methylated Suppliers

Global( 78)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
Zhengzhou Alfa Chemical Co.,Ltd	+8618530059196	sale04@alfachem.cn	China	12190	58
TargetMol Chemicals Inc.	+17819995354	marketing@targetmol.com	United States	32281	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6391	58
Nantong HI-FUTURE Biology Co., Ltd.	+undefined18051384581	sales@chemhifuture.com	China	3135	58
TargetMol Chemicals Inc.		support@targetmol.com	United States	38665	58
LEAPCHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	43340	58
Shanghai Acmec Biochemical Technology Co., Ltd.	+86-18621343501; +undefined18621343501	product@acmec-e.com	China	33338	58
Aladdin Scientific		tp@aladdinsci.com	United States	57505	58
Wuhan Jingkang en Biomedical Technology Co., Ltd	+8613720134139	orders@jknbiochem.com	China	5221	58

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
Zhengzhou Alfa Chemical Co.,Ltd	58
TargetMol Chemicals Inc.	58
InvivoChem	58
Nantong HI-FUTURE Biology Co., Ltd.	58
TargetMol Chemicals Inc.	58
LEAPCHEM CO., LTD.	58
Shanghai Acmec Biochemical Technology Co., Ltd.	58
Aladdin Scientific	58
Wuhan Jingkang en Biomedical Technology Co., Ltd	58

View Lastest Price from Z-Vad-fmk, non-methylated manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2025-05-27	Z-VAD-FMK 161401-82-7	US $121.00-438.00 / mg		99.79%	10g	TargetMol Chemicals Inc.

Z-VAD-FMK
161401-82-7
US $121.00-438.00 / mg
99.79%
TargetMol Chemicals Inc.

Z-Vad-fmk, non-methylated Spectrum

Z-Vad-fmk, non-methylated(161401-82-7)¹HNMR

161401-82-7(Z-Vad-fmk, non-methylated)Related Search:

ZT-12-037-01 (Z)-CAPSAICIN ZSTK474 Z-FA-FMK Z-PHE-DL-ALA-FLUOROMETHYLKETONE

CASPASE-8 INHIBITOR II Z-DEVD-FMK Z-VAD-FMK

1of2

Z-VAL-ALA-ASP-(OH)-FLUOROMETHYL KETONE Z-VAD-FMK (Caspase Inhibitor VI) Carbobenzyloxy-Val-Ala-Asp-alpha-fluoromethylketone L-Alaninamide, N-[(phenylmethoxy)carbonyl]-L-valyl-N-[(1S)-1-(carboxymethyl)-3-fluoro-2-oxopropyl]- L-Alaninamide, N-[(phenylmethoxy)carbonyl]-L-valyl-N-[(1S)-1-(carboxymethyl)-3-fluoro-2-oxopropyl]- (9ci) L-Alaninamide, N-[(phenylmethoxy)carbonyl]-L-valyl-N-[1-(carboxymethyl)-3-fluoro-2-oxopropyl]-, (S)- Z-VAD-FMK, Free Acid Z-VAD(OH)-FMK (Caspase Inhibitor VI) Caspase Inhibitor VI - CAS 161401-82-7 - Calbiochem abs817872 (5S,8S,11S)-11-(2-Fluoroacetyl)-5-isopropyl-8-methyl-3,6,9-trioxo-1-phenyl-2-oxa-4,7,10-triazatridecan-13-oic acid Z-VAD inhibit,Inhibitor,ZVADFMK,Hela,Z VAD FMK,Caspase,Antiapoptosis,cells,pan-caspase Z-VAD-FMK, 10 mM in DMSO 161401-82-7 C21H28FN3O7