Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>Prucalopride Succinate

Prucalopride Succinate

Prucalopride Succinate Structure
Prucalopride Succinate structure
CAS No.
179474-85-2
Chemical Name:
Prucalopride Succinate
Synonyms
R-108512;RESOLOR; R-108512;Resolor Succinate;PRUCALOPRIDE SUCCITE;Prucalopride Impurity;Prucalopride Succinat;Priucapride succinate;Prucalopride Succinate;Prucalopride Succinate WS;PRUCALOPRIDE INTERMEDIATES
CBNumber:
CB42510031
Molecular Formula:
C22H32ClN3O7
Molecular Weight:
485.96
MDL Number:
MFCD00948731
MOL File:
179474-85-2.mol
Last updated:2024-03-20 08:57:53
Request For Quotation

Prucalopride Succinate Properties

Melting point >196°C (dec.)
storage temp. Sealed in dry,Room Temperature
solubility DMSO (Slightly), Methanol (Slightly)
form Solid
color White to Pale Brown
InChIKey QZRSNVSQLGRAID-UHFFFAOYSA-N
SMILES C(O)(=O)CCC(O)=O.O1C2=C(C(NC3CCN(CCCOC)CC3)=O)C=C(Cl)C(N)=C2CC1
FDA UNII 4V2G75E1CK

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H412-H302
Precautionary statements  P273-P501-P264-P270-P301+P312-P330-P501

Prucalopride Succinate price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC P838950 PrucaloprideSuccinate 179474-85-2 250mg $275 2021-12-16 Buy
ChemScene CS-3907 Prucalopridesuccinate 99.83% 179474-85-2 200mg $270 2021-12-16 Buy
Medical Isotopes, Inc. 48434 PrucaloprideSuccinate 179474-85-2 50mg $675 2021-12-16 Buy
ChemScene CS-3907 Prucalopridesuccinate 99.83% 179474-85-2 50mg $96 2021-12-16 Buy
AK Scientific Y0234 Prucalopridesuccinate 179474-85-2 100mg $147 2021-12-16 Buy
Product number Packaging Price Buy
P838950 250mg $275 Buy
CS-3907 200mg $270 Buy
48434 50mg $675 Buy
CS-3907 50mg $96 Buy
Y0234 100mg $147 Buy

Prucalopride Succinate Chemical Properties,Uses,Production

Chemical Properties

Butanedioic acid 4-amino-5-chloro-2,3-dihydro-N-[1-(3-methoxypropyl)-4-piperidinyl]-7-benzofurancarboxamide is Off-White to Pale Brown Solid

Uses

Butanedioic acid 4-amino-5-chloro-2,3-dihydro-N-[1-(3-methoxypropyl)-4-piperidinyl]-7-benzofurancarboxamide is a selective 5-HT4 receptor agonist used effective for chronic constipation, but is not currently approved in the U.S. Prucalopride is approved for the treatment of chronic constipation in Europe.

Uses

Prucalopride is a selective 5-HT4 receptor agonist used effective for chronic constipation, but is not currently approved in the U.S. Prucalopride is approved for the treatment of chronic constipation in Europe.

Clinical Use

Prucalopride succinate, a first-in-class dihydrobenzofurancarboxamide, is a selective serotonin (5- HT4) receptor agonist. The drug, marketed under the brand name Resolor®, possesses enterokinetic activity and was developed by the Belgian-based pharmaceutical firm Movetis. Prucalopride alters colonic motility patterns via serotonin 5-HT4 receptor stimulation, triggering the central propulsive force for defecation.

Synthesis

The preparation of prucalopride succinate begins with the commercially available salicylic aniline 124. Acidic esterification, acetylation of the aniline nitrogen atom, and ambient-temperature chlorination via sulfuryl chloride (SO2Cl2) converted aminophenol 124 to acetamidoester 125 in 83% yield over the course of three steps. An unique set of conditions involving sodium tosylchloramide (chloramine T) trihydrate and sodium iodide were then employed to convert 125 to o-phenolic iodide 126, which then underwent sequential Sonogashira/cyclization reaction utilizing TMS-acetylene with tetramethylguanidine (TMG) in the presence of silica gel to furnish the benzofuran progenitor of 127. Hydrogenation of this intermediate benzofuranyl Sonagashira product saturated the 2,3-benzofuranyl bond while leaving the chlorine atom intact, ultimately delivering dihydrobenzofuran 127 in excellent yield for the two step sequence. Base-induced saponification and acetamide removal gave rise to acid 128. This acid was activated as the corresponding mixed anhydride and treated with commercial piperidine 129 to construct prucalopride which was stirred at room temperature for 24 hours in ethanolic succinic acid to provide prucalopride succinate (XI). The yield for the formation of the salt was not provided.

Synthesis_179474-85-2

Prucalopride Succinate Preparation Products And Raw materials

Raw materials

Preparation Products

Prucalopride Succinate Suppliers

Global( 238)Suppliers
Supplier Tel Email Country ProdList Advantage
Shanghai Innopharm Industrial Co., Ltd. 		+86-21-59960785 +86-17701845089 sales@hoyaopharm.com China 261 58
Hefei TianRui Pharmaceutical Chemical Co., Ltd.
+86-0551-68665055 +86-+86-18616906106 sales@trywchem.com China 129 58
Nanjing Shizhou Biotechnology Co., Ltd
+86-15850508050 +86-15850508050 sean.lv@synzest.com China 323 58
Hangzhou ICH Biofarm Co., Ltd 		+undefined8613073685410 sales@ichemie.com China 985 58
Capot Chemical Co.,Ltd. 		571-85586718 +8613336195806 sales@capotchem.com China 29797 60
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21695 55
Hangzhou FandaChem Co.,Ltd. 		008657128800458; +8615858145714 fandachem@gmail.com China 9352 55
Shanghai Yingrui Biopharma Co., Ltd. 		+86-21-33585366 - 03@ sales03@shyrchem.com CHINA 738 60
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32480 60
career henan chemical co 		+86-0371-86658258 sales@coreychem.com China 29914 58
Supplier Advantage
Shanghai Innopharm Industrial Co., Ltd. 		58
Hefei TianRui Pharmaceutical Chemical Co., Ltd.
58
Nanjing Shizhou Biotechnology Co., Ltd
58
Hangzhou ICH Biofarm Co., Ltd 		58
Capot Chemical Co.,Ltd. 		60
Henan Tianfu Chemical Co.,Ltd. 		55
Hangzhou FandaChem Co.,Ltd. 		55
Shanghai Yingrui Biopharma Co., Ltd. 		60
ATK CHEMICAL COMPANY LIMITED 		60
career henan chemical co 		58

Related articles

View Lastest Price from Prucalopride Succinate manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Prucalopride Succinate pictures 2023-11-01 Prucalopride Succinate
179474-85-2
 US $0.00 / kg 1kg 98% 500kg Hangzhou ICH Biofarm Co., Ltd
Prucalopride succinate pictures 2021-07-13 Prucalopride succinate
179474-85-2
 US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd
Prucalopride succinate pictures 2021-07-09 Prucalopride succinate
179474-85-2
 US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd

Prucalopride Succinate Spectrum

Prucalopride Succinate(179474-85-2)1HNMR

179474-85-2(Prucalopride Succinate)Related Search:

Prucalopride Impurity H Prucalopride Impurity D Bortezomib Edoxaban (tosylate Monohydrate) (+)-JQ1
Entinostat Afatinib Rapamycin Palonosetron Hydrochloride Acetylene
1-Naphthaleneacetic acid Prucalopride Impurity K Prucalopride Impurity C Prucalopride Impurity F Prucalopride Impurity I
Prucalopride Impurity E Prucalopride Impurity G Prucalopride Impurity J

1of4

Butanedioic acid 4-amino-5-chloro-2,3-dihydro-N-[1-(3-methoxypropyl)-4-piperidinyl]-7-benzofurancarboxamide Prucalopride Succinate Prucalopride Succinate API PRUCALOPRIDE INTERMEDIATES Prucalopride Succinat Prucalopride Succinate WS Butanedioic acid, compd. with 4-amino-5-chloro-2,3-dihydro-N-[1-(3-methoxypropyl)-4-piperidinyl]-7-benzofurancarboxamide (1:1) Prucalopride Impurity R-108512 RESOLOR; R-108512 7-cyclopenta[b]pyrancarboxamide 4-amino-5-chloro-N-[1-(3-methoxypropyl)piperidin-4-yl]-2,3-dihydro-1-benzofuran-7-carboxamide,butanedioic acid 4-amino-5-chloro-N-(1-(3-methoxypropyl)piperidin-4-yl)-2,3-dihydrobenzofuran-7-carboxamide succinate 4-Amino-5-chloro-2,3-dihydro-N-[1-(3-methoxypropyl)-4-piperidinyl]-7-benzofurancarboxamide Butanedioic Acid Prucalopride succinate, 98.5%, a selective high affinity 5-HT4 receptor agonist Resolor Succinate Prucalopride Succinate USP/EP/BP Prucalopride Succinate (R-108512, R-93877) Butanedioic acid 4-amino-5-chloro-2,3-dihydro-N-[1-(3-methox... Prucalopride Succinate 13CD3Q: What is Prucalopride Succinate 13CD3 Q: What is the CAS Number of Prucalopride Succinate 13CD3 TIANFU-CHEM - Prucalopride Succinate 4-amino-5-chloro-N-[1-(3-methoxypropyl)piperidin-4-yl]-2,3-dihydro-1-benzofuran-7-carboxamide,butanedioicaci PRUCALOPRIDE SUCCITE Prucalopride Succinate 4-amino-5-chloro-N-(1-(3-methoxypropyl)piperidin-4-yl)-2,3 -dihydrobenzofuran-7-carboxamide succinate Priucapride succinate 179474-85-2 C18H26ClN3O3C4H6O4 C22H32N3O7Cl Inhibitors