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ChemicalBook >> CAS DataBase List >>(2R)-3-Cyclopentyl-2-[4-(methanesulfonyl)phenyl]-N-(thiazol-2-yl)propionamide

(2R)-3-Cyclopentyl-2-[4-(methanesulfonyl)phenyl]-N-(thiazol-2-yl)propionamide

(2R)-3-Cyclopentyl-2-[4-(methanesulfonyl)phenyl]-N-(thiazol-2-yl)propionamide Structure
(2R)-3-Cyclopentyl-2-[4-(methanesulfonyl)phenyl]-N-(thiazol-2-yl)propionamide structure
CAS No.
300353-13-3
Chemical Name:
(2R)-3-Cyclopentyl-2-[4-(methanesulfonyl)phenyl]-N-(thiazol-2-yl)propionamide
Synonyms
Ro 28-1675;Ro 0281675;RO281675,RO 28 1675;RO 028-1675;RO 0281675;RO 28-1675 (Ro 0281675);RO 28-1675 - RO 28-0450, (R)-;(2R)-3-Cyclopentyl-2-[4-(methanesulfonyl)phenyl]-N-(thiazol-2-yl)propionamide;BenzeneacetaMide, α-(cyclopentylMethyl)-4-(Methylsulfonyl)-N-2-thiazolyl-, (αR)-
CBNumber:
CB42516200
Molecular Formula:
C18H22N2O3S2
Molecular Weight:
378.51
MDL Number:
MOL File:
300353-13-3.mol
MSDS File:
SDS
Last updated:2025-11-10 14:44:25
Product description Number Pack Size Price
Glucokinase Activator III, Ro-28-1675 5.09665 10mg $245
RO-28-1675 99.95% CS-2016 5mg $258
(R)-3-CYCLOPENTYL-2-(4-METHANESULFONYL-PHENYL)-N-THIAZOL-2-YL-PROPIONAMIDE 95.00% API0004737 2MG $262
RO-28-1675 99.95% CS-2016 10mg $444
RO28-1675-RO28-0450,(R)- 99% Axon1356 2mg $115.5
Request For Quotation

(2R)-3-Cyclopentyl-2-[4-(methanesulfonyl)phenyl]-N-(thiazol-2-yl)propionamide Properties

Density 1.306
storage temp. Store at -20°C
solubility DMSO : 50 mg/mL (132.10 mM; Need ultrasonic)
form Powder
pka 8.65±0.50(Predicted)
color White to off-white
UNSPSC Code 51111800
NACRES NA.77

(2R)-3-Cyclopentyl-2-[4-(methanesulfonyl)phenyl]-N-(thiazol-2-yl)propionamide price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 5.09665 Glucokinase Activator III, Ro-28-1675 300353-13-3 10mg $245 2025-07-31 Buy
ChemScene CS-2016 RO-28-1675 99.95% 300353-13-3 5mg $258 2021-12-16 Buy
American Custom Chemicals Corporation API0004737 (R)-3-CYCLOPENTYL-2-(4-METHANESULFONYL-PHENYL)-N-THIAZOL-2-YL-PROPIONAMIDE 95.00% 300353-13-3 2MG $262 2021-12-16 Buy
ChemScene CS-2016 RO-28-1675 99.95% 300353-13-3 10mg $444 2021-12-16 Buy
Axon Medchem Axon1356 RO28-1675-RO28-0450,(R)- 99% 300353-13-3 2mg $115.5 2021-12-16 Buy
Product number Packaging Price Buy
5.09665 10mg $245 Buy
CS-2016 5mg $258 Buy
API0004737 2MG $262 Buy
CS-2016 10mg $444 Buy
Axon1356 2mg $115.5 Buy

(2R)-3-Cyclopentyl-2-[4-(methanesulfonyl)phenyl]-N-(thiazol-2-yl)propionamide Chemical Properties,Uses,Production

Definition

ChEBI: (2R)-3-cyclopentyl-2-(4-methylsulfonylphenyl)-N-(2-thiazolyl)propanamide is a member of acetamides.

Biological Activity

RO-28-1675 is a potent allosteric activator of glucokinase with EC50 of 54 nM. It can be used in type 2 diabetes research.

in vitro

RO-28-1675 can reverse the inhibitory action of the human glucokinase regulatory protein (GKRP).

in vivo

RO-28-1675 (50 mg/kg; po) reduces blood glucose levels in wild-type C57BL/6J mice.
RO-28-1675 (10 mg/kg; po) displays lower clearance and higher oral bioavailability.

Animal Model: 10 weeks old male C57BL/6J mice
Dosage: 50 mg/kg
Administration: Oral administration
Result: Reduced blood glucose levels.
Animal Model: C57BL/6J mice
Dosage: 10 mg/kg
Administration: Oral administr ation
Result: AUC 0-inf (5150 ng? h/mL), C max (1140 μg/mL) , T max (3.3 hours ), F po (92.8%) with 10 mg/kg orally administered.

target

EC50: 54 nM (glucokinase)

(2R)-3-Cyclopentyl-2-[4-(methanesulfonyl)phenyl]-N-(thiazol-2-yl)propionamide Preparation Products And Raw materials

Raw materials

Preparation Products

(2R)-3-Cyclopentyl-2-[4-(methanesulfonyl)phenyl]-N-(thiazol-2-yl)propionamide Suppliers

Global( 48)Suppliers
Supplier Tel Email Country ProdList Advantage
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49975 58
TargetMol Chemicals Inc. 		+1-781-999-5354; +17819995354 marketing@targetmol.com United States 32435 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6391 58
Hangzhou MolCore BioPharmatech Co.,Ltd. 		+86-057181025280; +8617767106207 sales@molcore.com China 49734 58
TargetMol Chemicals Inc. 		+17819995354 marketing@targetmol.com United States 19962 58
Chembest Research Laboratories Limited +86-21-20908456 sales@BioChemBest.com China 6003 61
Haoyuan Chemexpress Co., Ltd. 021-58950125 info@chemexpress.com China 7552 61
LETOPHARM LIMITED +86-21-5821 5861 sales@letopharm.com China 2384 58
SPIRO PHARMA eric_feng1954@126.com China 9248 55
BOC Sciences 16314854226 info@bocsci.com United States 9923 65
Supplier Advantage
CONIER CHEM AND PHARMA LIMITED 		58
TargetMol Chemicals Inc. 		58
InvivoChem 		58
Hangzhou MolCore BioPharmatech Co.,Ltd. 		58
TargetMol Chemicals Inc. 		58
Chembest Research Laboratories Limited 61
Haoyuan Chemexpress Co., Ltd. 61
LETOPHARM LIMITED 58
SPIRO PHARMA 55
BOC Sciences 65

View Lastest Price from (2R)-3-Cyclopentyl-2-[4-(methanesulfonyl)phenyl]-N-(thiazol-2-yl)propionamide manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
RO-28-1675 pictures 2025-11-10 RO-28-1675
300353-13-3
 US $396.00-649.00 / mg 98.13% 10g TargetMol Chemicals Inc.
  • RO-28-1675 pictures
  • RO-28-1675
    300353-13-3
  • US $396.00-649.00 / mg
  • 98.13%
  • TargetMol Chemicals Inc.

(2R)-3-Cyclopentyl-2-[4-(methanesulfonyl)phenyl]-N-(thiazol-2-yl)propionamide Spectrum

(2R)-3-Cyclopentyl-2-[4-(methanesulfonyl)phenyl]-N-(thiazol-2-yl)propionamide(300353-13-3)1HNMR
(2R)-3-Cyclopentyl-2-[4-(methanesulfonyl)phenyl]-N-(thiazol-2-yl)propionamide Ro 0281675 BenzeneacetaMide, α-(cyclopentylMethyl)-4-(Methylsulfonyl)-N-2-thiazolyl-, (αR)- Ro 28-1675 RO 028-1675;RO 0281675 RO 28-1675 - RO 28-0450, (R)- RO281675,RO 28 1675 RO 28-1675 (Ro 0281675) 300353-13-3