ChemicalBook >> CAS DataBase List >>1,1-Dimethylethyl-N-[(4-chlorophenyl)methyl]-N-[(5-nitro-2-thienyl)methyl])glycinate
1,1-Dimethylethyl-N-[(4-chlorophenyl)methyl]-N-[(5-nitro-2-thienyl)methyl])glycinate
![1,1-Dimethylethyl-N-[(4-chlorophenyl)methyl]-N-[(5-nitro-2-thienyl)methyl])glycinate Structure](CAS/GIF/1216744-19-2.gif)
- CAS No.
- 1216744-19-2
- Chemical Name:
- 1,1-Dimethylethyl-N-[(4-chlorophenyl)methyl]-N-[(5-nitro-2-thienyl)methyl])glycinate
- Synonyms
- SK4112;SR6452;GSK 4112;GSK4112,SR6452;SR6452; SR-6452; SR 6452;tert-butyl N-(4-chlorobenzyl)-N-((5-nitrothiophen-2-yl)methyl)glycinate;tert-Butyl2-((4-chlorobenzyl)((5-nitrothiophen-2-yl)methyl)amino)acetate;1,1-Dimethylethyl-N-[(4-chlorophenyl)methyl]-N-[(5-nitro-2-thienyl)methyl])glycinate;Glycine, N-[(4-chlorophenyl)methyl]-N-[(5-nitro-2-thienyl)methyl]-, 1,1-dimethylethyl ester;SR-6452,hepatic damage,HepG2,Apoptosis,mice,Inhibitor,gluconeogenesis,bmal1,HDAC,hepatic gene,probe,Jo2,inhibit,Fas,GSK-4112,SR 6452,GSK4112,transcription,GSK 4112
- CBNumber:
- CB42518693
- Molecular Formula:
- C18H21ClN2O4S
- Molecular Weight:
- 396.89
- MDL Number:
- MFCD12912412
- MOL File:
- 1216744-19-2.mol
- MSDS File:
- SDS
Last updated:2023-06-30 15:45:59
| Melting point | 95 - 96°C |
|---|---|
| Boiling point | 486.7±45.0 °C(Predicted) |
| Density | 1.296±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | Chloroform (Slightly), Methanol (Slightly, Heated) |
| pka | 3.87±0.50(Predicted) |
| form | powder |
| color | off-white to tan |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Symbol(GHS) | GHS05,GHS08 |
|||||||||
| Signal word | Danger | |||||||||
| Signal word | Danger | |||||||||
| Hazard statements | H318-H334 | |||||||||
| Hazard statements | H318-H334 | |||||||||
| Precautionary statements | P261-P280-P305+P351+P338-P342+P311 | |||||||||
| Precautionary statements | P261-P280-P305+P351+P338-P342+P311 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 41-43 | |||||||||
| Safety Statements | 26-36/37/39 | |||||||||
| WGK Germany | 1 | |||||||||
| NFPA 704 |
|
1,1-Dimethylethyl-N-[(4-chlorophenyl)methyl]-N-[(5-nitro-2-thienyl)methyl])glycinate price More Price(26)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | G0673 | GSK4112 ≥98% (HPLC) | 1216744-19-2 | 5MG | $174 | 2023-06-20 | Buy |
| Sigma-Aldrich | G0673 | GSK4112 ≥98% (HPLC) | 1216744-19-2 | 25MG | $557 | 2023-06-20 | Buy |
| Cayman Chemical | 11931 | GSK4112 ≥98% | 1216744-19-2 | 5mg | $65 | 2024-03-01 | Buy |
| Cayman Chemical | 11931 | GSK4112 ≥98% | 1216744-19-2 | 10mg | $121 | 2024-03-01 | Buy |
| Cayman Chemical | 11931 | GSK4112 ≥98% | 1216744-19-2 | 25mg | $286 | 2024-03-01 | Buy |
1,1-Dimethylethyl-N-[(4-chlorophenyl)methyl]-N-[(5-nitro-2-thienyl)methyl])glycinate Chemical Properties,Uses,Production
Uses
GSK 4112 is a synthetic ligand for REV-ERBα, a member of the nuclear receptor superfamily that functions as a receptor for the porphoryin heme. GSK 4112 mimics the action of heme acting as agonist and suppresses the expression of REV-ERBα target genes involved in gluconeogenesis.
Biochem/physiol Actions
GSK4112 is a rev-erbα, (orphan nuclear receptor NR1D1) agonist, the first agent able to reset the circadian clock in a phase-dependent manner. Rev-erbα impacts the precision of the circadian clock by repressing target gene activities with the help of a nuclear receptor co-repressor complex (NCoR) and HDAC3. GSK4112 competes with heme (rev-erb′s natural ligand) and enhances co-repressor complex recruitment and thus, repression of transcription. suggests that pharmacological modulation through Rev-erb may provide new routes to treat metabolic diseases, especially disorders of adipogenesis regulated by rev-erba.
storage
Store at +4°C
1,1-Dimethylethyl-N-[(4-chlorophenyl)methyl]-N-[(5-nitro-2-thienyl)methyl])glycinate Preparation Products And Raw materials
Raw materials
Preparation Products
1,1-Dimethylethyl-N-[(4-chlorophenyl)methyl]-N-[(5-nitro-2-thienyl)methyl])glycinate Suppliers
Global( 75)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| SHANGHAI T&W PHARMACEUTICAL CO., LTD. | +86-021-61551413 +8618813727289 | contact@trustwe.com | China | 5738 | 58 |
| Tianjin Xinshengjiahe Science & Technology Development Co,.Ltd | +86-86-22-87899925 +86-8618522618860 | 18522618860@163.com | China | 694 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 96815 | 76 |
View Lastest Price from 1,1-Dimethylethyl-N-[(4-chlorophenyl)methyl]-N-[(5-nitro-2-thienyl)methyl])glycinate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
![1,1-Dimethylethyl-N-[(4-chlorophenyl)methyl]-N-[(5-nitro-2-thienyl)methyl])glycinate pictures](https://img.chemicalbook.com/ProductImageEN/2019-12/Small/50071fa4-0500-465a-ba4f-a3dcad54af45.jpg) |
2019-12-26 | 1,1-Dimethylethyl-N-[(4-chlorophenyl)methyl]-N-[(5-nitro-2-thienyl)methyl])glycinate
1216744-19-2
|
US $1.00 / g | 1g | 99% | 200kg | Career Henan Chemical Co |
-
- 1,1-Dimethylethyl-N-[(4-chlorophenyl)methyl]-N-[(5-nitro-2-thienyl)methyl])glycinate
1216744-19-2
- US $1.00 / g
- 99%
- Career Henan Chemical Co
1,1-Dimethylethyl-N-[(4-chlorophenyl)methyl]-N-[(5-nitro-2-thienyl)methyl])glycinate
GSK 4112
SR6452
GSK4112,SR6452
tert-Butyl2-((4-chlorobenzyl)((5-nitrothiophen-2-yl)methyl)amino)acetate
SR6452; SR-6452; SR 6452
tert-butyl N-(4-chlorobenzyl)-N-((5-nitrothiophen-2-yl)methyl)glycinate
SK4112
Glycine, N-[(4-chlorophenyl)methyl]-N-[(5-nitro-2-thienyl)methyl]-, 1,1-dimethylethyl ester
SR-6452,hepatic damage,HepG2,Apoptosis,mice,Inhibitor,gluconeogenesis,bmal1,HDAC,hepatic gene,probe,Jo2,inhibit,Fas,GSK-4112,SR 6452,GSK4112,transcription,GSK 4112
1216744-19-2
Chelating Agents & Ligands, Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals, Sulfur & Selenium Compounds