N-[3-(1H-Benzimidazol-2-yl)-4-chlorophenyl]-3,4,5-triethoxybenzamide
![N-[3-(1H-Benzimidazol-2-yl)-4-chlorophenyl]-3,4,5-triethoxybenzamide Structure](CAS/GIF/329196-48-7.gif)
- CAS No.
- 329196-48-7
- Chemical Name:
- N-[3-(1H-Benzimidazol-2-yl)-4-chlorophenyl]-3,4,5-triethoxybenzamide
- Synonyms
- SANT-2;Hh Signaling Antagonist XIV, SANT-2;Hh Signaling Antagonist XIV, SANT-2 - CAS 329196-48-7 - Calbiochem;N-[3-(1H-Benzimidazol-2-yl)-4-chlorophenyl]-3,4,5-triethoxybenzamide;N-(3-(1H-Benzo[d]imidazol-2-yl)-4-chlorophenyl)-3,4,5-triethoxybenzamide;Benzamide, N-[3-(1H-benzimidazol-2-yl)-4-chlorophenyl]-3,4,5-triethoxy-
- CBNumber:
- CB42518880
- Molecular Formula:
- C26H26ClN3O4
- Molecular Weight:
- 479.96
- MDL Number:
- MOL File:
- 329196-48-7.mol
- MSDS File:
- SDS
N-[3-(1H-Benzimidazol-2-yl)-4-chlorophenyl]-3,4,5-triethoxybenzamide price More Price(18)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML0644 | SANT-2 ≥95% (HPLC) | 329196-48-7 | 5mg | $152 | 2024-03-01 | Buy |
| Cayman Chemical | 21208 | SANT-2 | 329196-48-7 | 5mg | $73 | 2024-03-01 | Buy |
| Cayman Chemical | 21208 | SANT-2 | 329196-48-7 | 10mg | $138 | 2024-03-01 | Buy |
| Sigma-Aldrich | SML0644 | SANT-2 ≥95% (HPLC) | 329196-48-7 | 25mg | $589 | 2023-01-07 | Buy |
| Cayman Chemical | 21208 | SANT-2 | 329196-48-7 | 25mg | $324 | 2024-03-01 | Buy |
N-[3-(1H-Benzimidazol-2-yl)-4-chlorophenyl]-3,4,5-triethoxybenzamide Chemical Properties,Uses,Production
Uses
SANT-2 is an inhibitor of Smo (Hedgehog signaling pathway) and SAG.
General Description
A nanomolar Smoothened (smo) antagonist that exhibits 2.3- and 6-fold weaker biological activity than SANT-1 (Cat. No. 559303), respectively, in antagonizing ShhNp- and SAG-stimulated hedgehog pathway activation in HEK 293-based (Shh-LIGHT2) reporter assays. Competitive binding studies show full replacement of Smo-bound cyclopamine (Cat. No. 239803) by SANT-1 and SANT-2 (Ki = 2.4 and 8.4 nM, respectively), while SANT-1 and SANT-2 are shown to compete against Smo-bound SAG-1.3 (Cat. Nos. 566660 & 566661) in an allosteric manner and that only SANT-2, but not SANT-1, is able to completely compete off bound SAG-1.3 (100% vs. 40% replacement by the respective compound at 10 μM).
Biochem/physiol Actions
SANT-2 is a potent sonic hedgehog pathway (shh) antagonist that directly inhibits by binding to the smoothened receptor.
N-[3-(1H-Benzimidazol-2-yl)-4-chlorophenyl]-3,4,5-triethoxybenzamide Preparation Products And Raw materials
Raw materials
Preparation Products
N-[3-(1H-Benzimidazol-2-yl)-4-chlorophenyl]-3,4,5-triethoxybenzamide Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15848 | 69 |
| Shanghai Tauto Biotech Co., Ltd. | 021-51320588 | tauto@tautobiotech.com | China | 3989 | 66 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8449 | 60 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9709 | 58 |
| MQ (shanghai) Pharmaceuticals Co., Ltd. | 13761635123 | 1014988033@qq.com | China | 4979 | 55 |
| BOC Sciences | -- | info@bocsci.com | USA | 0 | 65 |