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Melanotan 1

CAS No.
75921-69-6
Chemical Name:
Melanotan 1
Synonyms
NDP-MSH;CUV1647);Melanotan Ⅰ;MELANOTAN I;Melanotan-1;Melanotropin;Afamelanotide;[Nle4,D-Phe7]α-MSH;MT-I (Melanotan I);(Nle4,D-Phe7)-a-MSH
CBNumber:
CB4252333
Molecular Formula:
C78H111N21O19
Molecular Weight:
1646.85
MDL Number:
MFCD00151715
MOL File:
75921-69-6.mol
MSDS File:
SDS
Last updated:2024-03-27 16:59:26

Melanotan 1 Properties

Density 1.46±0.1 g/cm3(Predicted)
RTECS OS1830200
storage temp. −20°C
form Solid
pka 4.43±0.10(Predicted)
Water Solubility Soluble to 0.60 mg/ml in sterile water
Sequence Ac-Ser-Tyr-Ser-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2
InChIKey UAHFGYDRQSXQEB-LEBBXHLNSA-N
CAS DataBase Reference 75921-69-6(CAS DataBase Reference)
FDA UNII QW68W3J66U
NCI Drug Dictionary afamelanotide
ATC code D02BB02

SAFETY

Risk and Safety Statements

WGK Germany  3

Melanotan 1 price More Price(14)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich M8764 [Nle4, D-Phe7]-α-Melanocyte Stimulating Hormone trifluoroacetate salt ≥95% (HPLC) 75921-69-6 1mg $145.8 2024-03-01 Buy
Alfa Aesar J66191 [Nle4, D-Phe7] alpha-Melanocyte Stimulating Hormone amide trifluoroacetate salt 75921-69-6 1mg $161 2024-03-01 Buy
Tocris 3013 [Nle4,D-phe7]-alpha-MSH 75921-69-6 1 $184 2021-12-16 Buy
Usbiological 256004 [Nle4,D-Phe7]-α-MSH 75921-69-6 1mg $432 2021-12-16 Buy
Biosynth Carbosynth FM39599 Melanotan 1 75921-69-6 5mg $456 2021-12-16 Buy
Product number Packaging Price Buy
M8764 1mg $145.8 Buy
J66191 1mg $161 Buy
3013 1 $184 Buy
256004 1mg $432 Buy
FM39599 5mg $456 Buy

Melanotan 1 Chemical Properties,Uses,Production

Features

Afamelanotide is a potent, linear synthetic analog of the naturally occurring peptide hormone α-melanocyte-stimulating hormone (α-MSH).Modified to have a stronger binding affinity to melanocortin- 1 receptor (MC1R) and a smaller disassociation constant, afamelanotide has a longer half-life and subsequently exerts longer pharmacologic activity than its parent hormone.

Uses

Melanotan 1 is a highly potent melanotropin with extended biological activity and resistance to enzymatic degredation by serum enzymes. [Nle4, D-Phe7]-α-Melanocyte Stimulating Hormone trifluoroacetate salt has been used to detect its effect on O2 consumption and CO2 production in C57BL/6 mice. It is also used to determine its effect on leptin secretion in the primary cultures of differentiated adipocytes.

Definition

ChEBI: Afamelanotide is a polypeptide comprising of 13 amino acids which is an analogue of alpha-melanocyte stimulating hormone. It is approved as a dermatologic drug for the prevention of phototoxicity in adult patients with erythropoietic protoporphyria. It has a role as a dermatologic drug.

General Description

[Nle4, D-Phe7]-α-melanocyte stimulating hormone is a potent analogue of α;-melanocyte-stimulating hormone (α -MSH). αMSH is a tridecapeptide, mostly produced by the cells in the brain, pituitary and in circulation.

Biochem/physiol Actions

[Nle4, D-Phe7]-α-melanocyte stimulating hormone is 100 times more potent than α-MSH in stimulating melanoma tyrosinase, which is a rate limiting enzyme in melanin biosynthesis and is 26 times as potent as α-MSH in S91adenylate cyclase assay. α –MSH has an essential role to play in melanin production in animals. It also regulates development of several skin diseases, including cutaneous inflammation and hyper-proliferative skin diseases.

Side effects

The TGA has previously warned consumers against the use of Melanotan-I and Melanotan-II for tanning and weight loss. Side-effects include darkened skin, increased moles and freckles, nausea, vomiting, loss of appetite, flushing of the face, involuntary stretching and yawning, and spontaneous erections.

storage

Store at -20°C

Melanotan 1 Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 236)Suppliers
Supplier Tel Email Country ProdList Advantage
Wuhan Han Sheng New Material Technology Co.,Ltd
+8617798174412 admin01@hsnm.com.cn China 2120 58
Hebei Xinsheng New Material Technology Co., LTD.
+86-16632316109 xinshengkeji@xsmaterial.com China 1104 58
BOC Sciences
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zhuzhou dingcheng meihei comestic co.,ltd
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Shanghai Chinqesen Biotechnology Co., Ltd.
+86-16628886292 +86-19521323435 sales2@qschem-pharma.com China 253 58
Dorne Chemical Technology co. LTD
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Wuhan senwayer century chemical Co.,Ltd
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Henan Tengmao Chemical Technology Co. LTD
+8615238638457 salesvip2@hntmhg.com China 415 58

Related articles

  • Introduction of Melanotan I
  • Melanotan I(Afamelanotide) is a first-in-class, synthetic, 13-amino acid peptide analogue of the endogenous alpha melanocyte-s....
  • Nov 24,2021

View Lastest Price from Melanotan 1 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Melanotan 1 pictures 2024-03-28 Melanotan 1
75921-69-6
US $30.00 / box 1box 98% 2000box hebei hongtan Biotechnology Co., Ltd
MT1 pictures 2024-03-28 MT1
75921-69-6
US $0.00 / kg 1kg 0.99 10T Shandong Hanjiang Chemical Co., Ltd
Melanotan 1 pictures 2024-03-28 Melanotan 1
75921-69-6
US $1.00 / g 1g 99% 100kg Dorne Chemical Technology co. LTD
  • Melanotan 1 pictures
  • Melanotan 1
    75921-69-6
  • US $30.00 / box
  • 98%
  • hebei hongtan Biotechnology Co., Ltd
  • MT1 pictures
  • MT1
    75921-69-6
  • US $0.00 / kg
  • 0.99
  • Shandong Hanjiang Chemical Co., Ltd
  • Melanotan 1 pictures
  • Melanotan 1
    75921-69-6
  • US $1.00 / g
  • 99%
  • Dorne Chemical Technology co. LTD
[NLE4,D-PHE]ALPHA-MELANOCYTE STIMULATING HORMONE (NLE4,D-PHE7)-ALPHA-MSH [Nle4,D-Phe7]α-MSH Ac-L-Ser-L-Tyr-L-Ser-L-Nle-L-Glu-L-His-D-Phe-L-Arg-L-Trp-Gly-L-Lys-L-Pro-L-Val-NH2 N-Ac-L-Ser-L-Tyr-L-Ser-L-Nle-L-Glu-L-His-D-Phe-L-Arg-L-Trp-Gly-L-Lys-L-Pro-L-Val-NH2 [Nle4,DPhe7] a-MSH, amide [Nle4,DPhe7] a-MSH, amide:Melanotan Ⅰ [Nle4, D-Phe7]-α-MSH, amide [Nle4]-α-MSH, amide (Nle4,D-Phe7)-α-MSH AfaMelanotide, NDP-MSH, Melanotan 1, CUV1647 (Nle4,D-Phe7)-a-MSH AfaMelanotide, NDP-MSH, Melanotan 1, CUV1647 NLE4, D-PHE7 .ALPHA.-MSH, NDP-MSH, MELANOTAN I Melanotan Ⅰ Acetate [Nle4, D-Phe7] α-MSH NDP-MSH Melanotan Ⅰ [Nle4,D-Phe7] α -MSH NDP-MSH Melanotan I alpha-melanotropin, [Nle3,D-Phe7], trifluoroacetate Ac-Ser-Tyr-Ser-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2 acetate salt a-Melanotropin (swine),4-L-norleucine-7-D-phenylalanine- Afamelanotide acetate [NLE4, D-PHE7]-ALPHA-MSH, AMIDE [NLE4,D-PHE7]-ALPHA-MELANOCYTE-STIMULATING HORMONE [NLE4,DPHE7] ALPHA-MELANOCYTE STIMULATING HORMONE, AMIDE NDP-MSHAC-SER-TYR-SER-NLE-GLU-HIS-D-PHE-ARG-TRP-GLY-LYS-PRO-VAL-NH2 NDP-MSH Melanotan ① Acetate [NLE4, DPHE7] A-MSH, AMIDE; MELANOTAN Ⅰ Melanotan Ⅰ MELANOTAN I AC-SYS-NLE-EHFRWGKPV-NH2 AC-SER-TYR-SER-NLE-GLU-HIS-D-PHE-ARG-TRP-GLY-LYS-PRO-VAL-NH2 NLE-4-D-PHE-7-A-MELANOCYTE*STIMULATING H ORMONE [Nle4,D-Phe7]-MSHNDP-MSH [Nle4,D-Phe7] a-Melanocyte stimulating hormone,amide [nle4, d-phe7]-α-melanocyte stimulating hormone trifluoroacetate salt MSH, 4-Nle-7-Phe-alpha- Melanotan I Acetate MelanotanⅠ(α-MSH) 4-Nle-7-phe-alpha-msh 4-Norleucyl-7-phenylalanine-alpha-msh Melanotan-1 Melanotropin Melanotan II(10mg) /Mt-2 for Tanning Melanotan 2 CAS NO.75921-69-6 CAS NO.75921-69-6 Afamelanotide [Nle4, D-Phe7]-α-Melanocyte Stimulating Hormone (MSH), amide [Nle4, D-Phe7]-α-Melanocyte stimulating hormone trifluoroacetate salt, ≥95% (HPLC) N-Acetyl-L-seryl-L-tyrosyl-L-seryl-L-norleucyl-L-a-glutamyl-L-histidyl-D-phenylalanyl-L-arginyl-L-tryptophylglycyl-L-lysyl-L-prolyl-L-valinamide α-Melanotropin (swine), 4-L-norleucine-7-D-phenylalanine- Melanotan-1 USP/EP/BP 4-L-norleucine-7-D-phenylalanine-α-Melanotropin (Nle4,D-Phe7)-α-MSH Melanotan 1 (MT1) acetate MT I (Melanotan-1) MT-I (Melanotan I) Melanotan I (MT1) acetate [Nle4, D-Phe7]-α-Melanocyte Stimulating Hormone trifluoroacetate salt Melanotan I (Afamelanotide CUV1647) α-Melanotropin (swine), 4-L-norleucine-7-D-phenylalanine-