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(S)-TERT-LEUCINOL

(S)-TERT-LEUCINOL structure

CAS No.: 112245-13-3

Chemical Name:: (S)-TERT-LEUCINOL

Synonyms: L-TERT-LEUCINOL;H-TLE-OL;L-T-LEUCINOL;H-(TBU)GLY-OL;(S)-TERT-LEACINOL;(S)-TERT-LEUCINOL;L-T-BUTYLGLYCINOL;(S)-TERT-LENCINOL;(+)-tert-Leucinol;L**L-tert-Leucinol

CBNumber:: CB4253158

Molecular Formula:: C6H15NO

Molecular Weight:: 117.19

MDL Number:: MFCD00192250

MOL File:: 112245-13-3.mol

Last updated:2026-01-13 11:19:20

Product description	Number	Pack Size	Price
L-tert-Leucinol 98%	407739	1g	$41.3
L-tert-Leucinol 98%	407739	5g	$100.93
L-tert-Leucinol >97.0%(GC)(T)	L0160	1g	$62
L-tert-Leucinol >97.0%(GC)(T)	L0160	5g	$186
L-tert-Leucinol, 98% (99% ee)	07-7224	1g	$67
More product size

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(S)-TERT-LEUCINOL Properties

Melting point	30-34 °C(lit.)
Boiling point	114-116 °C (10 mmHg)
Density	0.9 g/mL at 25 °C(lit.)
refractive index	38 ° (C=1.5, EtOH)
Flash point	194 °F
storage temp.	Keep in dark place,Inert atmosphere,2-8°C
solubility	soluble in Methanol
pka	12.88±0.10(Predicted)
form	Crystalline Low Melting Mass or Liquid
color	White or colorless
optical activity	[α]26/D +37°, c = 1.5 in ethanol
BRN	3600321
Major Application	peptide synthesis
InChI	InChI=1S/C6H15NO/c1-6(2,3)5(7)4-8/h5,8H,4,7H2,1-3H3/t5-/m1/s1
InChIKey	JBULSURVMXPBNA-RXMQYKEDSA-N
SMILES	C(O)[C@@H](N)C(C)(C)C
CAS DataBase Reference	112245-13-3(CAS DataBase Reference)
UNSPSC Code	12352209
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P264-P271-P280-P302+P352-P305+P351+P338

target organs

Respiratory system

PPE

dust mask type N95 (US), Eyeshields, Gloves

Hazard Codes

Risk Statements

36/37/38

Safety Statements

26-36

WGK Germany

10-23

HS Code

29221990

Storage Class

11 - Combustible Solids

Hazard Classifications

Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

NFPA 704

	2
2		0

(S)-TERT-LEUCINOL price More Price(40)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	407739	L-tert-Leucinol 98%	112245-13-3	1g	$41.3	2025-07-31	Buy
Sigma-Aldrich	407739	L-tert-Leucinol 98%	112245-13-3	5g	$100.93	2025-07-31	Buy
TCI Chemical	L0160	L-tert-Leucinol >97.0%(GC)(T)	112245-13-3	1g	$62	2025-07-31	Buy
TCI Chemical	L0160	L-tert-Leucinol >97.0%(GC)(T)	112245-13-3	5g	$186	2025-07-31	Buy
Strem Chemicals	07-7224	L-tert-Leucinol, 98% (99% ee)	112245-13-3	1g	$67	2024-03-01	Buy

Product number	Packaging	Price	Buy
407739	1g	$41.3	Buy
407739	5g	$100.93	Buy
L0160	1g	$62	Buy
L0160	5g	$186	Buy
07-7224	1g	$67	Buy

(S)-TERT-LEUCINOL Chemical Properties,Uses,Production

Chemical Properties

white crystalline low melting mass or

Uses

Useful amino acid employed in various asymmetric reactions.

reaction suitability

reaction type: solution phase peptide synthesis

Synthesis

20859-02-3

112245-13-3

GENERAL STEPS: Example 8-1; To a 100 mL Schlenk tube purged with nitrogen was added 4.00 g (30.5 mmol) of (S)-tert-leucine and 40 mL of tetrahydrofuran, and the temperature of the reaction system was adjusted to 10°C. Over 5 min, 1.46 g (61.0 mmol) of lithium borohydride was added to the suspension in batches, followed by adjusting the temperature of the system to 20 °C. Over 30 minutes, 7.44 g (67.1 mmol) of trimethylmethylsilyl chloride was added slowly and dropwise, then the mixture was heated to 65 °C and stirred continuously at this temperature for 3 hours. Upon completion of the reaction, the mixture was cooled to 10 °C and quenched by the slow dropwise addition of 4 mL of methanol over 20 min. After concentrating the reaction mixture using a rotary evaporator, 40 mL of 4 M aqueous sodium hydroxide solution was added and stirred for 1 hour at room temperature. Subsequently, 40 mL of tert-butyl methyl ether was added for extraction and the organic layer was separated and dried with anhydrous sodium sulfate. After filtration to remove the desiccant, the tert-butyl methyl ether was removed by atmospheric pressure distillation. Finally, the 70 to 75 °C fraction was collected by reduced pressure distillation (0.3 kPa) to give 2.96 g of (S)-tert-leucinol in 83% yield.

References

[1] Journal of the American Chemical Society, 2003, vol. 125, # 21, p. 6362 - 6363
[2] Chemical Communications, 2010, vol. 46, # 3, p. 445 - 447
[3] Beilstein Journal of Organic Chemistry, 2013, vol. 9, p. 1637 - 1642
[4] Journal of Organic Chemistry, 1992, vol. 57, # 17, p. 4732 - 4740
[5] Organic Letters, 2018, vol. 20, # 16, p. 4806 - 4810

(S)-TERT-LEUCINOL Preparation Products And Raw materials

Raw materials

L-tert-Leucine Lithium borohydride Methanol Tetrahydrofuran Chlorotrimethylsilane

Preparation Products

(R)-(+)-2-Methyl-2-propanesulfinamide Oxazole, 2,2'-(1-methylethylidene)bis[4,5-dihydro-4-methyl-, (4S,4'S)- 2,2'-Bioxazole, 4,4'-bis(1,1-dimethylethyl)-4,4',5,5'-tetrahydro-, (4S,4'S)- (S,S)-(-)-2,2'-ISOPROPYLIDENEBIS(4-TERT-BUTYL-2-OXAZOLINE) Olorinab

(4R)-4-T-BUTYL-2-METHYL 2-OXAZOLINE

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(S)-TERT-LEUCINOL Suppliers

Global( 316)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shanghai Acmec Biochemical Technology Co., Ltd.	+86-18621343501; +undefined18621343501	product@acmec-e.com	China	33325	58
Taizhou Tianhong Biochemistry Technology Co., Ltd.	0523-86132544	sales@thbiochem.com	CHINA	305	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29830	58
Jinan Carbotang Biotech Co.,Ltd.	+8615866703830	figo.gao@foxmail.com	China	8497	58
Accela ChemBio Inc.	+1-858-6993322	info@accelachem.com	United States	21193	58
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22963	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19552	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49977	58
Neostar United (Changzhou) Industrial Co., Ltd.	+86-0519-85551759 +8613506123987	marketing1@neostarunited.com	China	8830	58

Supplier	Advantage
Shanghai Acmec Biochemical Technology Co., Ltd.	58
Taizhou Tianhong Biochemistry Technology Co., Ltd.	60
career henan chemical co	58
Jinan Carbotang Biotech Co.,Ltd.	58
Accela ChemBio Inc.	58
Hubei xin bonus chemical co. LTD	58
BOC Sciences	58
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58
Neostar United (Changzhou) Industrial Co., Ltd.	58

View Lastest Price from (S)-TERT-LEUCINOL manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2025-12-01	(S)-TERT-LEUCINOL 112245-13-3	US $0.00 / kg	1kg	98%	1000kg	Shaanxi Dideu New Materials Co. Ltd
	2019-07-06	(S)-tert-Leucinol 112245-13-3	US $1.00 / kg	1kg	95%-99%	as request	Career Henan Chemical Co

(S)-TERT-LEUCINOL
112245-13-3
US $0.00 / kg
98%
Shaanxi Dideu New Materials Co. Ltd

(S)-tert-Leucinol
112245-13-3
US $1.00 / kg
95%-99%
Career Henan Chemical Co

(S)-TERT-LEUCINOL Spectrum

(S)-TERT-LEUCINOL(112245-13-3)¹HNMR (S)-TERT-LEUCINOL(112245-13-3)IR

112245-13-3((S)-TERT-LEUCINOL)Related Search:

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3,3-DIMETHYL-1-BUTANOL (R)-3,3-DIMETHYL-2-AMINOBUTANE (S)-(+)-2-Amino-1-butanol

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2-AMINO-3,3-DIMETHYL-1-BUTANOL L-T-LEUCINOL L-(+)-TERT-LEUCINOL L-T-BUTYLGLYCINOL (S)-2-AMINO-3,3-DIMETHYLBUTANOL (S)-2-AMINO-3,3-DIMETHYL-1-BUTANOL (S)-TERT-LEUCINOL (S)-TERT-LEACINOL (2S)-1-HYDROXY-3,3-DIMETHYL-BUTAN-2-YL]AZANIUM H-TLE-OL H-(TBU)GLY-OL (S)-TERT-LENCINOL (S)-2-Amino-3,3-dimethyl-1-butanol, L-tert-Leucinol (2R)-2-Amino-3,3-dimethyl-1-butanol (R)-3,3-Dimethyl-2-aminobutane-1-ol (+)-tert-Leucinol (2S)-2-Amino-3,3-dimethyl-1-butanol (S)-2-tert-Butyl-2-aminoethanol (S)-3,3-Dimethyl-2-amino-1-butanol (S)-tert-Leucinol,95% (S)-tert-Leucinol,98% L-tert-Leucinol,(S)-2-Amino-3,3-dimethyl-1-butanol (S)-tert-Leucinol,(S)-2-Amino-3,3-dimethyl-1-butanol, L-tert-Leucinol (2S)-2-Amino-3,3-dimethylbutan-1-ol (2S)-2-Amino-3,3-dimethylbutan-1-ol 99% L-tert-Leucinol, (2S)-2-Amino-3,3-dimethyl-1-hydroxybutane L-tert-Leucinol 98% L-tert-Leucinol L-Tert-Leucinol≥ 98% (GC) L-tert-Leucinol,99%e.e. L-tert-Leucinol, 98% (99% ee) L**L-tert-Leucinol (S)-2-Amino-3,3-dimethyl-1-hydroxybutane L-tert-Leucinol, 98%, for synthesis L-tert-Leucinol> 1-Butanol, 2-amino-3,3-dimethyl-, (2S)- (S)-TERT-LEUCINOL USP/EP/BP L-TERT-LEUCINOL L-tert leucine alcohol L-2-amino-3,3-dimethylbutan-1-ol L-tert-Leucinol,97% L-tert-Leucinol 112245-13-3 CH33CCHNH2CH2OH C6H16NO AMINE Peptide Synthesis Specialty Synthesis Chiral Building Blocks Amino Alcohols (Chiral) Amino Alcohols Amino Acid Derivatives Pharmaceutical Intermediates Amino Alcohols Amino Alcohols (Chiral) Chiral Building Blocks Synthetic Organic Chemistry Amino alcohols