OSI-027
- CAS No.
- 936890-98-1
- Chemical Name:
- OSI-027
- Synonyms
- CS-436;OSI-027;ASP4786;CPD2801;OSI-027, >=98%;OSI027;OSI 027;OSI-027 USP/EP/BP;OSI-027;OSI 027;ASP4786;trans-4-[4-Amino-5-(7-methoxy-1H-i;OSI-027 (ASP-4786, CERC-006, AEVI-006)
- CBNumber:
- CB42538725
- Molecular Formula:
- C21H22N6O3
- Molecular Weight:
- 406.44
- MDL Number:
- MFCD20275101
- MOL File:
- 936890-98-1.mol
| Melting point | >149°C (subl.) |
|---|---|
| Density | 1.59 |
| storage temp. | Hygroscopic, -20°C Freezer, Under inert atmosphere |
| solubility | DMSO (Slightly) |
| pka | 4.44±0.10(Predicted) |
| form | Solid |
| color | Pale Beige to Light Beige |
| FDA UNII | 25MKH1SZ0M |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P264-P270-P301+P312-P330-P501 | |||||||||
| NFPA 704 |
|
OSI-027 price More Price(23)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 17379 | OSI-027 ≥98% | 936890-98-1 | 1mg | $37 | 2024-03-01 | Buy |
| Cayman Chemical | 17379 | OSI-027 ≥98% | 936890-98-1 | 5mg | $134 | 2024-03-01 | Buy |
| Cayman Chemical | 17379 | OSI-027 ≥98% | 936890-98-1 | 10mg | $249 | 2024-03-01 | Buy |
| Cayman Chemical | 17379 | OSI-027 ≥98% | 936890-98-1 | 50mg | $670 | 2024-03-01 | Buy |
| TRC | A611910 | 4-(4-Amino-5-(7-methoxy-1H-indol-2-yl)imidazo[5,1-f][1,2,4]Triazin-7-yl)cyclohexanecarboxylicAcid | 936890-98-1 | 1mg | $65 | 2021-12-16 | Buy |
OSI-027 Chemical Properties,Uses,Production
Description
The mammalian target of rapamycin (mTOR) is a serine-threonine kinase that is central to two protein complexes, mTORC1 and mTORC2. These complexes are differentially regulated (e.g., only mTORC1 is sensitive to rapamycin ) and regulate different pathways. OSI-027 is an inhibitor of the catalytic site of mTOR and, as a result, inhibits both mTORC1 and mTORC2 (IC50s = 22 and 65 nM, respectively). It is selective for mTOR over phosphatidylinositol 3-kinase isoforms and DNA protein kinase. OSI-027 prohibits proliferation, induces autophagy, and potentiates apoptosis in BCR-ABL transformed cells and other cancer cells at 10 μM. OSI-027 is effective in vivo, blocking the phosphorylation of targets of mTORC1 and mTORC2 and suppressing tumor growth in several different human xenograft models.
Uses
OSI-027 is a kinase inhibitor with anti-tumor activity, used in treatment of breast cancer.
Definition
ChEBI: 4-[4-amino-5-(7-methoxy-2-indolylidene)-1H-imidazo[5,1-f][1,2,4]triazin-7-yl]-1-cyclohexanecarboxylic acid is a member of indoles.
target
mTORC
References
[1] bhagwat s v, gokhale p c, crew a p, et al. preclinical characterization of osi-027, a potent and selective inhibitor of mtorc1 and mtorc2: distinct from rapamycin. molecular cancer therapeutics, 2011, 10(8): 1394-1406.
OSI-027 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Biochempartner | 0086-13720134139 | candy@biochempartner.com | CHINA | 967 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 47465 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 29474 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| LEAP CHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 24738 | 58 |
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3136 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
