FMoc-NH-5(ethylene glycol)-acetic acid
- CAS No.
- 635287-26-2
- Chemical Name:
- FMoc-NH-5(ethylene glycol)-acetic acid
- Synonyms
- FmocNH-P5-CH2CO2H;FMoc-NH-PEG5-CH2COOH;Fmoc-PEG5-acetic acid;Fmoc-NH-5(ethylene glycol)-actic acid;FMoc-NH-5(ethylene glycol)-acetic acid;1-(9H-Fluoren-9-yl)-3-oxo-2,7,10,13,16,19-hexaoxa-4-azahenicosan-21-oic acid;17-[(9-Fluorenylmethoxycarbonyl)amino]-3,6,9,12,15-pentaoxaheptadecanoic acid;5,8,11,14,17-Pentaoxa-2-azanonadecanedioic acid 1-(9H-fluoren-9-ylmethyl) ester;Fmoc-NH-PEG5-CH2COOH(1-(9H-Fluoren-9-ylmethyl) 5,8,11,14,17-pentaoxa-2-azanonadecanedioate);FmocNH-PEG5-CH2COOH/5,8,11,14,17-Pentaoxa-2-azanonadecanedioic acid, 1-(9H-fluoren-9-ylmethyl) ester
- CBNumber:
- CB42546850
- Molecular Formula:
- C27H35NO9
- Molecular Weight:
- 517.57
- MDL Number:
- MFCD26142982
- MOL File:
- 635287-26-2.mol
- MSDS File:
- SDS
FMoc-NH-5(ethylene glycol)-acetic acid price More Price(10)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| AK Scientific | 0364AP | Fmoc-NH-PEG5-CH2COOH | 635287-26-2 | 250mg | $303 | 2021-12-16 | Buy |
| ChemPep | 280104 | Fmoc-NH-PEG5-CH2COOH | 635287-26-2 | 1g | $306 | 2021-12-16 | Buy |
| Activate Scientific | AS103968 | FmocNH-PEG5-CH2COOH 95+% | 635287-26-2 | 1g | $413 | 2021-12-16 | Buy |
| Apolloscientific | BIPG1412 | Fmoc-NH-PEG5-CH2COOH | 635287-26-2 | 500mg | $607 | 2021-12-16 | Buy |
| chempep | 280104 | Fmoc-NH-PEG5-CH2COOH >=95% | 635287-26-2 | 5g | $820 | 2021-12-16 | Buy |
FMoc-NH-5(ethylene glycol)-acetic acid Chemical Properties,Uses,Production
Description
Fmoc-NH-PEG5-CH2COOH is a PEG linker containing an Fmoc-protected amine and a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.
Biological Activity
Fmoc-NH-PEG5-CH2COOH is a degradable ADC linker for antibody drug conjugate (ADC) synthesis. It is also a PEG-based PROTAC linker, which can be used for PROTAC synthesis.
in vitro
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
target
| Cleavable
| Alkyl/ether
| PEGs
|
FMoc-NH-5(ethylene glycol)-acetic acid Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| 9i LLC | +18039569191 | MWan@NiNeiLab.com | United States | 418 | 58 |
| Chengdu Pukang Biotechnology Co., Ltd | 028-82550498 | export@pu-kang.com | CHINA | 210 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| SHANGHAI T&W PHARMACEUTICAL CO., LTD. | +86-021-61551413 +8618813727289 | contact@trustwe.com | China | 5738 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Wuhan Borenpharm Co., Ltd | 027-65563561 18717150066 | 3207347307@qq.com | CHINA | 1238 | 58 |
| Hangzhou Huarong Pharm Co., Ltd. | 571-86758373 +8613588754946 | sales@huarongpharm.com | CHINA | 3149 | 58 |
| Nextpeptide Inc | +86-0571-81612335 +8613336028439 | sales@nextpeptide.com | China | 19915 | 58 |
| Labnetwork lnc. | +86-27-50766799 +8618062016861 | contact@labnetwork.com | China | 19994 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49739 | 58 |
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