Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>A66

A66

A66 Structure
A66 structure
CAS No.
1166227-08-2
Chemical Name:
A66
Synonyms
CS-435;A 66;A-66;A66 USP/EP/BP;A66 PI3K inhibitor A-66;A66, 98%, a potent and specific p110α inhibitor;Phosphoinositide 3-kinase,inhibit,PI3K,A66,Inhibitor,A-66,A 66;(2S)-N1-[2-(tert-Butyl)-4'-methyl[4,5'-bithiazol]-2'-yl]-1,2-pyrrolidinedicarboxamide;(S)-N1-(2-(tert-Butyl)-4'-methyl-[4,5'-bithiazol]-2'-yl)pyrrolidine-1,2-dicarboxamide;(2S)-N1-(5-(2-tert-butylthiazol-4-yl)-4-methylthiazol-2-yl)pyrrolidine-1,2-dicarboxamide;(2S)-N1-[2-(1,1-Dimethylethyl)-4'-methyl[4,5'-bithiazol]-2'-yl]-1,2-pyrrolidinedicarboxamide
CBNumber:
CB42553771
Molecular Formula:
C17H23N5O2S2
Molecular Weight:
393.53
MDL Number:
MFCD22378485
MOL File:
1166227-08-2.mol
MSDS File:
SDS
Last updated:2023-06-30 15:45:59
Request For Quotation

A66 Properties

Density 1.354
storage temp. Sealed in dry,Store in freezer, under -20°C
solubility insoluble in H2O; ≥19.7 mg/mL in DMSO; ≥2.63 mg/mL in EtOH with gentle warming
form solid
pka 6.27±0.70(Predicted)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P280-P305+P351+P338
HS Code  29341000

A66 price More Price(36)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 17382 A 66 ≥98% 1166227-08-2 1mg $36 2024-03-01 Buy
Cayman Chemical 17382 A 66 ≥98% 1166227-08-2 5mg $95 2024-03-01 Buy
Cayman Chemical 17382 A 66 ≥98% 1166227-08-2 10mg $172 2024-03-01 Buy
Cayman Chemical 17382 A 66 ≥98% 1166227-08-2 25mg $384 2024-03-01 Buy
TRC A101100 A66 1166227-08-2 10mg $140 2021-12-16 Buy
Product number Packaging Price Buy
17382 1mg $36 Buy
17382 5mg $95 Buy
17382 10mg $172 Buy
17382 25mg $384 Buy
A101100 10mg $140 Buy

A66 Chemical Properties,Uses,Production

Description

A-66 is a potent, selective inhibitor of the PI3K isoform p110α (IC50 = 32 nM in a cell-free assay). It displays over 100-fold selectivity for p110α over other isoforms. A-66 is effective in vivo, suppressing the growth of SK-OV-3 tumor xenografts in mice. It also impairs all measures of in vivo insulin action in mice. A-66 partially suppresses B cell receptor-dependent Akt activation and proliferation.

Uses

A66 is a potent and specific p110α inhibitor. Inhibition of p110α can block phosphoinositide 3-kinase (PI3K) signalling and tumor growth in certain cell types.

Definition

ChEBI: (2S)-N1-[5-(2-tert-butyl-4-thiazolyl)-4-methyl-2-thiazolyl]pyrrolidine-1,2-dicarboxamide is a proline derivative.

Enzyme inhibitor

This potent and highly selective p110α inhibitor (FW = 393.53; CAS 1166227-08-2; Solubility: 79 mg/mL DMSO, 1 mg/mL H2O), also known as (2S)-N1-(5-(2-tert-butylthiazol-4-yl)-4-methylthiazol-2-yl)pyrrolidine-1, 2-dicarboxamide, has a IC50 value of 32 nM for the wild-type phosphoinositide-3 kinase p110 α as well as oncogenic forms of p110α such as p110α E545K (IC50 = 43 nM) and p110α H1047R (IC50 = 43 nM). A66 inhibition also demonstrated that cancer-specific mutations in the iSH2 (inter-SH2) and nSH2 (N-terminal SH2) domains of p85α, the regulatory subunit of phosphatidylinositide 3-kinase (PI3K), show gain of function, inducing oncogenic cellular transformation, stimulating cellular proliferation, and enhancing PI3K signaling.

storage

Store at -20°C

A66 Preparation Products And Raw materials

Raw materials

Preparation Products

A66 Suppliers

Global( 115)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32480 60
career henan chemical co 		+86-0371-86658258 sales@coreychem.com China 29914 58
Hubei Jusheng Technology Co.,Ltd. 		18871490254 linda@hubeijusheng.com CHINA 28180 58
Chongqing Chemdad Co., Ltd 		+86-023-61398051 +8613650506873 sales@chemdad.com China 39916 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 47465 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 19892 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		86-571-88216897,88216896 13588875226 sales@hzclap.com CHINA 6313 58
Dideu Industries Group Limited 		+86-29-89586680 +86-15129568250 1026@dideu.com China 29271 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 +1-2135480471 sales@sarms4muscle.com China 10523 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6393 58
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 		60
career henan chemical co 		58
Hubei Jusheng Technology Co.,Ltd. 		58
Chongqing Chemdad Co., Ltd 		58
CONIER CHEM AND PHARMA LIMITED 		58
TargetMol Chemicals Inc. 		58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		58
Dideu Industries Group Limited 		58
Zhejiang J&C Biological Technology Co.,Limited 		58
InvivoChem 		58

View Lastest Price from A66 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
A66 pictures 2019-07-06 A66
1166227-08-2
 US $2.00 / kg 1kg 99% 100kg Career Henan Chemical Co
  • A66 pictures
  • A66
    1166227-08-2
  • US $2.00 / kg
  • 99%
  • Career Henan Chemical Co

A66 Spectrum

A66(1166227-08-2)1HNMR

1166227-08-2(A66)Related Search:

Bortezomib AZD-8055 AZD6482 Wnt-C59 CAL-101
4H-PYRIDO[1,2-A]PYRIMIDIN-4-ONE, 7-METHYL-2-(4-MORPHOLINYL)-9-[1-(PHENYLAMINO)ETHYL]-

1of2

(2S)-N1-[2-(tert-Butyl)-4'-methyl[4,5'-bithiazol]-2'-yl]-1,2-pyrrolidinedicarboxamide (2S)-N1-(5-(2-tert-butylthiazol-4-yl)-4-methylthiazol-2-yl)pyrrolidine-1,2-dicarboxamide (2S)-N1-[2-(tert-Butyl)-4'-methyl[4,5'-bithiazol]-2'-yl]-1,2-pyrrolidinedicarboxamide A 66 CS-435 A66, 98%, a potent and specific p110α inhibitor (2S)-N1-[2-(1,1-Dimethylethyl)-4'-methyl[4,5'-bithiazol]-2'-yl]-1,2-pyrrolidinedicarboxamide A 66;A-66 1,2-Pyrrolidinedicarboxamide, N1-[2-(1,1-dimethylethyl)-4'-methyl[4,5'-bithiazol]-2'-yl]-, (2S)- A66 USP/EP/BP A66 PI3K inhibitor A-66 Phosphoinositide 3-kinase,inhibit,PI3K,A66,Inhibitor,A-66,A 66 (S)-N1-(2-(tert-Butyl)-4'-methyl-[4,5'-bithiazol]-2'-yl)pyrrolidine-1,2-dicarboxamide 1166227-08-2 C17H23N5O2S2 Inhibitors Akt mTOR PI3K PI3K/Akt/mTOR