ChemicalBook >> CAS DataBase List >>Toceranib Phosphate
Toceranib Phosphate
- CAS No.
- 874819-74-6
- Chemical Name:
- Toceranib Phosphate
- Synonyms
- PHA 291639E;SU11654 phosphate;PHA 291639 phosphate;Toceranib (phosphate);PHA 291639E (phosphate);Toceranib phosphate(SU 11654);Toceranib (PHA 291639) phosphate;5-[(Z)-(5-fluoro-2-oxo-1H-indol-3-ylidene)methyl]-2,4-dimethyl-N-(2-pyrrolidin-1-ylethyl)-1H-pyrrole-3-carboxamide;(Z)-5-((5-Fluoro-2-oxoindolin-3-ylidene)methyl)-2,4-dimethyl-n-(2-(pyrrolidin-1-yl)ethyl)-1h-pyrrole-3-carboxamide phosphate;5-[(Z)-(5-Fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-N-(2-pyrrolidin-1-ylethyl)-1H-pyrrole-3-carboxamide
- CBNumber:
- CB42563239
- Molecular Formula:
- C22H28FN4O6P
- Molecular Weight:
- 494.46
- MDL Number:
- MFCD25372034
- MOL File:
- 874819-74-6.mol
Last updated:2024-03-05 16:03:24
| Melting point | >270°C (dec.) |
|---|---|
| storage temp. | -20°C Freezer |
| solubility | DMSO (Slightly, Heated) |
| form | Solid |
| color | Yellow to Dark Orange |
| InChIKey | AOORBROPMMRREB-HBPAQXCTSA-N |
| SMILES | P(O)(O)(O)=O.C(/C1NC(C)=C(C(=O)NCCN2CCCC2)C=1C)=C1/C(NC2=CC=C(F)C=C/12)=O |
| FDA UNII | 24F9PF7J3R |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
Toceranib Phosphate price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | T525503 | ToceranibPhosphate | 874819-74-6 | 100mg | $60 | 2021-12-16 | Buy |
| TRC | T525503 | ToceranibPhosphate | 874819-74-6 | 10mg | $45 | 2021-12-16 | Buy |
| ChemScene | CS-1231 | Toceranibphosphate | 874819-74-6 | 10mg | $50 | 2021-12-16 | Buy |
| Biosynth Carbosynth | BT162330 | Toceranib phosphate | 874819-74-6 | 5mg | $50 | 2021-12-16 | Buy |
| AK Scientific | 6555BB | Toceranibphosphate | 874819-74-6 | 10mg | $120 | 2021-12-16 | Buy |
Toceranib Phosphate Chemical Properties,Uses,Production
Description
Toceranib phosphate is a kinase inhibitor with both antitumor and antiangiogenic activity through inhibition of KIT, vascular endothelial growth factor receptor 2, and PDGFRβ. It is a receptor tyrosine kinase inhibitor and is used in the treatment of canine mast cell tumor also called mastocytoma. It may also have an anti-angiogenic effect.
Uses
Toceranib Phosphate is a useful compound in the treatment of chemotherapy-induced diarrhea.
Side effects
Common side effects of Toceranib Phosphate may include diarrhoea, decreased or lack of appetite, claudication or weight loss. Less common side effects include muscle pain, low white blood cell count, low blood protein levels, blood clots (which may appear as swelling in the legs or difficulty breathing), pancreatitis, loss of nose colour, changes in skin hair, nosebleeds, seizures, high blood pressure and itching. Serious side effects include prolonged loss of appetite, severe diarrhoea or bloody stools, bruising or bleeding. In cats, gastrointestinal effects, low blood counts, liver and kidney problems, and hair loss have been reported.
target
KIT
Toceranib Phosphate Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 94)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Masteam Bio-tech Co., Ltd. | +86-15200345168 +86-15200345168 | bruce.lei@masteam.com | CHINA | 153 | 58 |
| Hpets Biotech Company (Chongqing) Co.,ltd | +8613340353813 | info@hanpets.com | China | 26 | 58 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 15371 | 58 |
| Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | fandachem@gmail.com | China | 9352 | 55 |
| Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 | product@chemlin.com.cn | CHINA | 3012 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| Biochempartner | 0086-13720134139 | candy@biochempartner.com | CHINA | 967 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| Hubei Ipure Biology Co., Ltd | +8613367258412 | ada@ipurechemical.com | China | 10326 | 58 |
| AFINE CHEMICALS LIMITED | 0571-85134551 | info@afinechem.com | CHINA | 15377 | 58 |
View Lastest Price from Toceranib Phosphate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-02-27 | Toceranib phosphate
874819-74-6
|
US $0.00 / kg | 1kg | 99% | 100 tons | Hpets Biotech Company (Chongqing) Co.,ltd | |
 |
2022-09-27 | Toceranib Phosphate
874819-74-6
|
US $0.00-0.00 / kg | 1kg | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd. |
-
- Toceranib phosphate
874819-74-6
- US $0.00 / kg
- 99%
- Hpets Biotech Company (Chongqing) Co.,ltd
-
- Toceranib Phosphate
874819-74-6
- US $0.00-0.00 / kg
- 98%
- Henan Aochuang Chemical Co.,Ltd.
874819-74-6(Toceranib Phosphate)Related Search:
1H-Pyrrole-3-carboxaMide, 5-[(Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)Methyl]-2,4-diMethyl-N-[2-(1-pyrrolidinyl)ethyl]-, phosphate (1:1)
5-[(Z)-(5-Fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-N-[2-(1-pyrrolidinyl)ethyl]-1H-pyrrole-3-carboxamide phosphate
PHA 291639E
Toceranib (phosphate)
Toceranib (PHA 291639) phosphate
Toceranib phosphate(SU 11654)
5-[(Z)-(5-fluoro-2-oxo-1H-indol-3-ylidene)methyl]-2,4-dimethyl-N-(2-pyrrolidin-1-ylethyl)-1H-pyrrole-3-carboxamide,phosphoric acid
SU11654 phosphate
PHA 291639 phosphate
(Z)-5-((5-Fluoro-2-oxoindolin-3-ylidene)methyl)-2,4-dimethyl-n-(2-(pyrrolidin-1-yl)ethyl)-1h-pyrrole-3-carboxamide phosphate
PHA 291639E (phosphate)
1H-Pyrrole-3-carboxamide, 5-[(Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-N-[2-(1-pyrrolidinyl)ethyl]-, phosphate (1:1) (9CI, ACI)
5-[(Z)-(5-fluoro-2-oxo-1H-indol-3-ylidene)methyl]-2,4-dimethyl-N-(2-pyrrolidin-1-ylethyl)-1H-pyrrole-3-carboxamide
5-[(Z)-(5-Fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-N-(2-pyrrolidin-1-ylethyl)-1H-pyrrole-3-carboxamide
5-[(Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-N-[2-(1-pyrrolidinyl)ethyl]-1H-Pyrrole-3-carboxamide phosphate (1:1) (9CI ACI)
5-(Z)-(5-Fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl-2,4-dimethyl-N-2-(pyrrolidin-1-yl)ethyl-1H-pyrrol-3-carboxamide phosphate (1:1)
874819-74-6
C22H25FN4O2H3PO4
C22H25FN4O2H3O4P
API