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CAY10603

CAY10603 Structure
CAY10603 structure
CAS No.
1045792-66-2
Chemical Name:
CAY10603
Synonyms
Isox;187257;BML-281;CAY10603;HDAC6 Inhibitor;CAY10603 CAY10603;HDAC6 inhibitor ISOX;CAY10603; CAY-10603; CAY 10603.;Histone Deacetylase Inhibitor VIII - CAS 1045792-66-2 - Calbiochem;tert-butyl 4-(3-((7-(hydroxyamino)-7-oxoheptyl)carbamoyl)isoxazol-5-yl)phenylcarbamate
CBNumber:
CB42590439
Molecular Formula:
C22H30N4O6
Molecular Weight:
446.5
MDL Number:
MFCD17010286
MOL File:
1045792-66-2.mol
Last updated:2023-05-18 11:31:13
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CAY10603 Properties

Density 1.231±0.06 g/cm3(Predicted)
storage temp. +2C to +8C
solubility ≥22.35 mg/mL in DMSO; insoluble in EtOH; ≥24.85 mg/mL in H2O
form Beige to light brown solid
pka 9.47±0.20(Predicted)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338

CAY10603 price More Price(23)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 13146 CAY10603 ≥95% 1045792-66-2 1mg $48 2024-03-01 Buy
Cayman Chemical 13146 CAY10603 ≥95% 1045792-66-2 5mg $176 2024-03-01 Buy
Cayman Chemical 13146 CAY10603 ≥95% 1045792-66-2 10mg $324 2024-03-01 Buy
Cayman Chemical 13146 CAY10603 ≥95% 1045792-66-2 25mg $578 2024-03-01 Buy
TRC H999763 HDAC6Inhibitor 1045792-66-2 500μg $55 2021-12-16 Buy
Product number Packaging Price Buy
13146 1mg $48 Buy
13146 5mg $176 Buy
13146 10mg $324 Buy
13146 25mg $578 Buy
H999763 500μg $55 Buy

CAY10603 Chemical Properties,Uses,Production

Description

Histone deacetylase 6 (HDAC6) is a class II HDAC that represses transcription by removing acetyl groups from histones. In addition, HDAC6 deacetylases tubulin, which is important in regulating microtubule stability and function. CAY10603 is a potent and selective inhibitor of HDAC6 (IC50 = 0.002 nM, as compared with 271, 252, 0.42, 6851, and 90.7 nM for HDAC1, 2, 3, 8, and 10, respectively). Also, CAY10603 prevents the growth of several pancreatic cancer cell lines (IC50 = 0.1-1 μM). The HDAC6 inhibitor is more active in inhibiting cell growth than the broad spectrum HDAC inhibitor suberoylanilide hydroxamic acid (SAHA).

Uses

HDAC6 Inhibitor is an inhibitor of HDAC6.

Definition

ChEBI: N-[4-[3-[[[7-(hydroxyamino)-7-oxoheptyl]amino]-oxomethyl]-5-isoxazolyl]phenyl]carbamic acid tert-butyl ester is a carbamate ester.

General Description

A cell-permeable, active site Zn2+-targeting phenylisoxazolo-hydroxamate that acts a potent and highly selective HDAC6 inhibitor (IC50 = 0.002, 0.42, 90.7, 252, 271 and 6851 nM against HDAC-6, -3, -10, -2, -1 and -8, respectively). Shown to be more potent than SAHA in inhibiting the proliferation of a panel of pancreatic cancer cell lines (IC50<1.0 μM).

CAY10603 Preparation Products And Raw materials

Raw materials

Preparation Products

CAY10603 Suppliers

Global( 81)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32480 60
Hubei Jusheng Technology Co.,Ltd. 		18871490254 linda@hubeijusheng.com CHINA 28180 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 19892 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		86-571-88216897,88216896 13588875226 sales@hzclap.com CHINA 6313 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6393 58
Baynoe Chem (Suzhou) Co., Ltd. 		+86-512 65869404 +86-18934593683 sales06@baynoe.com China 292 58
LEAP CHEM CO., LTD. 		+86-852-30606658 market18@leapchem.com China 24738 58
ShenZhen Trendseen Biological Technology Co.,Ltd. 		13417589054 trendseenbio@gmail.com China 11681 58
Suzhou Yuanrui Bio-Tech Co., Ltd 		+86-18106132862 +86-18106132862 sales02@yuanruibio.com China 278 58
Aladdin Scientific 		+1-833-552-7181 sales@aladdinsci.com United States 57511 58
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 		60
Hubei Jusheng Technology Co.,Ltd. 		58
TargetMol Chemicals Inc. 		58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		58
InvivoChem 		58
Baynoe Chem (Suzhou) Co., Ltd. 		58
LEAP CHEM CO., LTD. 		58
ShenZhen Trendseen Biological Technology Co.,Ltd. 		58
Suzhou Yuanrui Bio-Tech Co., Ltd 		58
Aladdin Scientific 		58

CAY10603 Spectrum

CAY10603(1045792-66-2)MS

1045792-66-2(CAY10603)Related Search:

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1H-Benz[de]isoquinoline-2(3H)-butanamide SCRIPTAID SPLITOMICIN Sodium 4-phenylbutyrate BENZOTRIAZOL-1-YL-(2,4-DICHLORO-PHENYL)-METHANONE
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ACY-1215 Imatinib Nexturastat A

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N-[4-[3-[[[7-(Hydroxyamino)-7-oxoheptyl]amino]carbonyl]-5-isoxazolyl]phenyl]carbamic acid 1,1-dimethylethyl ester HDAC6 inhibitor ISOX CAY10603 Isox tert-butyl 4-(3-((7-(hydroxyamino)-7-oxoheptyl)carbamoyl)isoxazol-5-yl)phenylcarbamate HDAC6 Inhibitor Histone Deacetylase Inhibitor VIII - CAS 1045792-66-2 - Calbiochem CAY10603; CAY-10603; CAY 10603. 187257 tert-butyl N-[4-[3-[[7-(hydroxyamino)-7-oxoheptyl]carbamoyl]-1,2-oxazol-5-yl]phenyl]carbamate BML-281 Carbamic acid, N-[4-[3-[[[7-(hydroxyamino)-7-oxoheptyl]amino]carbonyl]-5-isoxazolyl]phenyl]-, 1,1-dimethylethyl ester BML 281,inhibit,Histone deacetylases,BML281,CAY-10603,Inhibitor,CAY10603,CAY 10603,HDAC CAY10603 CAY10603 1045792-66-2 Inhibitors