ChemicalBook >> CAS DataBase List >>Gefapixant
Gefapixant
- CAS No.
- 1015787-98-0
- Chemical Name:
- Gefapixant
- Synonyms
- Gefapixant;MK-7264;MK7264;MK 7264;CS-2846;EOS-6104;EOS-61047;RO-4926219;Gefapixant(AF-219;Gefapixant(AF-219,MK-7264)
- CBNumber:
- CB42596673
- Molecular Formula:
- C14H19N5O4S
- Molecular Weight:
- 353.4
- MDL Number:
- MFCD24539325
- MOL File:
- 1015787-98-0.mol
Last updated:2024-04-23 14:32:41
| Boiling point | 606.3±65.0 °C(Predicted) |
|---|---|
| Density | 1.391±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMSO:38.0(Max Conc. mg/mL);107.53(Max Conc. mM) |
| pka | 9.90±0.60(Predicted) |
| FDA UNII | 6K6L7E3F1L |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P264-P270-P271-P280-P301+P312-P302+P352-P304-P304+P340-P305+P351+P338-P312-P321-P330-P332+P313-P337+P313-P340-P362-P403-P403+P233-P405-P501 |
Gefapixant price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0021727 | Gefapixant 99.62% | 1015787-98-0 | 5mg | $110 | 2021-12-16 | Buy |
| Biosynth Carbosynth | BM170818 | MK 7264 | 1015787-98-0 | 10mg | $125 | 2021-12-16 | Buy |
| ChemScene | CS-0021727 | Gefapixant 99.62% | 1015787-98-0 | 10mg | $160 | 2021-12-16 | Buy |
| AK Scientific | 8545BB | Gefapixant | 1015787-98-0 | 10mg | $218 | 2021-12-16 | Buy |
| ChemScene | CS-0021727 | Gefapixant 99.62% | 1015787-98-0 | 25mg | $320 | 2021-12-16 | Buy |
Gefapixant Chemical Properties,Uses,Production
Description
Gefapixant was approved in Japan in 2022 for adult patients with refractory or unexplained chronic cough, marketed under the name Lyfnua.The drug was authorised by the European Medicines Agency (EMA) in September 2023 for the same indication. However, the FDA refused to approve gefapixant for the treatment of adults with refractory or unexplained chronic cough.
Uses
Gefapixant is an orally active and potent purinergic P2X3 receptor (P2X3R) antagonist, with IC50 values of ~30 nM versus recombinant hP2X3 homotrimers and 100-250 nM at hP2X2/3 heterotrimeric receptors. Gefapixant can be used for the research of chronic cough and knee osteoarthritis.
Gefapixant Preparation Products And Raw materials
Raw materials
Preparation Products
Gefapixant Suppliers
Global( 92)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| Shochem(Shanghai) Co.,Ltd | 86-21-50800795 | info@shochem.com | CHINA | 288 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
| CR Corporation Lomited | fred.wen@crcorporation.cn | CHINA | 12069 | 58 | |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418684 +8618949823763 | sales@tnjchem.com | China | 25363 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
View Lastest Price from Gefapixant manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-01-09 | 5-(2,4-DiaMino-pyriMidin-5-yloxy)-4-isopropyl-2-Methoxy-benzenesulfonaMide
1015787-98-0
|
US $9.80 / KG | 1g | ≥99% | 100kg | Career Henan Chemical Co |
-
- 5-(2,4-DiaMino-pyriMidin-5-yloxy)-4-isopropyl-2-Methoxy-benzenesulfonaMide
1015787-98-0
- US $9.80 / KG
- ≥99%
- Career Henan Chemical Co
5-(2,4-DiaMino-pyriMidin-5-yloxy)-4-isopropyl-2-Methoxy-benzenesulfonaMide
EOS-61047
EOS-6104
Gefapixant(AF-219,MK-7264)
RO-4926219
5-[(2,4-diamino-5-pyrimidinyl)oxy]-2-methoxy-4-(1-methylethyl)Benzenesulfonamide
Benzenesulfonamide, 5-[(2,4-diamino-5-pyrimidinyl)oxy]-2-methoxy-4-(1-methylethyl)-
GEFAPIXANT; MK-7264; MK 7264; MK7264; AF-219; AF219; AF 219; RO4926219; RO-4926219; RO 4926219;
GEFAPIXANT;AF-219;MK-7264;AF 219;MK 7264;AF219;MK7264
MK 7264
MK7264
CS-2846
Gefapixant(AF-219
5-[(2,4-Diamino-5-pyrimidinyl)oxy]-4-isopropyl-2-methoxybenzenesulfonamide
Gefapixant
MK-7264
Gefapixant,AF-219,MK 7264,inhibit,MK7264,chronic cough,P2X3,knee osteoarthritis,Inhibitor,AF 219,P2X Receptor,P2XRs
1015787-98-0
APIS