ChemicalBook >> CAS DataBase List >>(S)-3-aMino-1-hydroxy-3,4-dihydroquinolin-2(1H)-one hydrochloride
(S)-3-aMino-1-hydroxy-3,4-dihydroquinolin-2(1H)-one hydrochloride
- CAS No.
- 177943-33-8
- Chemical Name:
- (S)-3-aMino-1-hydroxy-3,4-dihydroquinolin-2(1H)-one hydrochloride
- Synonyms
- PF-04859989HCl;PF-04859989 HCl;PF04859989 hydrochloride;PF-4859989 hydrochloride;PF-04859989 hydrochloride;PF-04859989 hydrochloride >=98% (HPLC);(3S)-3-amino-1-hydroxy-3,4-dihydroquinolin-2-one;(3S)-3-Amino-1-hydroxy-3,4-dihydroquinolin-2(1H)-one;L-3-Amino-3,4-dihydro-1-hydroxycarbstyril hydrochloride;(S)-3-aMino-1-hydroxy-3,4-dihydroquinolin-2(1H)-one hydrochloride
- CBNumber:
- CB42598844
- Molecular Formula:
- C9H11ClN2O2
- Molecular Weight:
- 214.64884
- MDL Number:
- MFCD22419400
- MOL File:
- 177943-33-8.mol
- MSDS File:
- SDS
Last updated:2023-09-04 15:51:00
(S)-3-aMino-1-hydroxy-3,4-dihydroquinolin-2(1H)-one hydrochloride price More Price(7)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | PZ0250 | PF-04859989 hydrochloride ≥98% (HPLC) | 177943-33-8 | 5mg | $115 | 2024-03-01 | Buy |
| Sigma-Aldrich | PZ0250 | PF-04859989 hydrochloride ≥98% (HPLC) | 177943-33-8 | 25mg | $462 | 2024-03-01 | Buy |
| American Custom Chemicals Corporation | CCH0033300 | (S)-3-AMINO-1-HYDROXY-3,4-DIHYDROQUINOLIN-2(1H)-ONE HYDROCHLORIDE 95.00% | 177943-33-8 | 5MG | $497.41 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | CCH0033300 | (S)-3-AMINO-1-HYDROXY-3,4-DIHYDROQUINOLIN-2(1H)-ONE HYDROCHLORIDE 95.00% | 177943-33-8 | 1G | $1575 | 2021-12-16 | Buy |
| Axon Medchem | Axon2924 | PF04859989hydrochloride-L-3-Amino-3,4-dihydro-1-hydroxycarbstyrilhydrochloride 99% | 177943-33-8 | 10mg | $121 | 2021-12-16 | Buy |
(S)-3-aMino-1-hydroxy-3,4-dihydroquinolin-2(1H)-one hydrochloride Chemical Properties,Uses,Production
Biochem/physiol Actions
PF-04859989 is a brain-penetrable irreversible inhibitor of kynurenine amino transferase II (KAT II), the enzyme responsible for most of the brain synthesis of kynurenic acid, which has been implicated in several psychiatric and neurological disorders, including schizophrenia and bipolar disorder, and thought to impair cognitive function. PF-04859989 has IC50 values of 23 nM for hKAT II and 263 nM for rKAT II. PF-04859989 is ~1000-fold selective for KAT II over human KAT I, KAT III, and KAT IV. PF-04859989 prevented ketamine-induced disruption of performance in memory tasks in both rodents and nonhuman primates.
(S)-3-aMino-1-hydroxy-3,4-dihydroquinolin-2(1H)-one hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
(S)-3-aMino-1-hydroxy-3,4-dihydroquinolin-2(1H)-one hydrochloride Suppliers
Global( 20)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Labnetwork lnc. | +86-27-50766799 +8618062016861 | contact@labnetwork.com | China | 19994 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Shanghai Aladdin Bio-Chem Technology Co.,LTD | 400-6206333 18521732826; | market@aladdin-e.com | China | 25015 | 65 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
| ShangHai Angti Biotechnology Co., Ltd. | 13764913901 | info@angtibio.com | China | 4483 | 55 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9709 | 58 |
| Beijing Solarbio Science & Tecnology Co., Ltd. | 010-50973130 4009686088 | 3193328036@qq.com | China | 29797 | 68 |
| Tianjin heowns Biochemical Technology Co., Ltd. | 400-6387771-6037 18920794737 | sales@heowns.com | China | 20506 | 60 |
| Jiangsu aikang biomedical research and development co., LTD | 025-66110311 13155353615 | qzhang@aikonchem.com | China | 15527 | 58 |
(S)-3-aMino-1-hydroxy-3,4-dihydroquinolin-2(1H)-one hydrochloride
(3S)-3-Amino-1-hydroxy-3,4-dihydroquinolin-2(1H)-one
L-3-Amino-3,4-dihydro-1-hydroxycarbstyril hydrochloride
PF04859989 hydrochloride
PF-04859989 hydrochloride
PF-4859989 hydrochloride
PF 04859989 hydrochloride - L-3-Amino-3,4-dihydro-1-hydroxycarbstyril hydrochloride
PF-04859989 hydrochloride >=98% (HPLC)
2(1H)-Quinolinone, 3-amino-3,4-dihydro-1-hydroxy-, monohydrochloride, (S)- (9CI)
(3S)-3-amino-1-hydroxy-3,4-dihydroquinolin-2-one
PF-04859989 HCl
PF-04859989HCl
disorders,schizophrenia,Inhibitor,inhibit,PF04859989 HCl,midbrain,psychiatric,PF 04859989 HCl,dopamine,neurons,cognitive ,impairment
177943-33-8