MI-3 (Menin-MLL Inhibitor)
- CAS No.
- 1271738-59-0
- Chemical Name:
- MI-3 (Menin-MLL Inhibitor)
- Synonyms
- MI-3;CS-1809;5-dihydro-5;Menin-MLL inhibitor 3;MI-3 (Menin-MLL Inhibitor);MI-3 (Menin-MLL Inhibitor) USP/EP/BP;5-dimethyl-2-thiazolyl)-1-piperazinyl]-6-(1-methylethyl);MI3,MI-3,Apoptosis,inhibit,Epigenetic Reader Domain,Inhibitor;4-[4-(4,5-Dihydro-5,5-dimethyl-2-thiazolyl)-1-piperazinyl]-6-(1-methylethyl)thieno[2,3-d]pyrimidine;Thieno[2,3-d]pyriMidine, 4-[4-(4,5-dihydro-5,5-diMethyl-2-thiazolyl)-1-piperazinyl]-6-(1-Methylethyl)-
- CBNumber:
- CB42624233
- Molecular Formula:
- C18H25N5S2
- Molecular Weight:
- 375.55
- MDL Number:
- MFCD28348362
- MOL File:
- 1271738-59-0.mol
- MSDS File:
- SDS
MI-3 (Menin-MLL Inhibitor) price More Price(19)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 27214 | MI-3 | 1271738-59-0 | 500μg | $37 | 2024-03-01 | Buy |
| Cayman Chemical | 27214 | MI-3 | 1271738-59-0 | 1mg | $65 | 2024-03-01 | Buy |
| Cayman Chemical | 27214 | MI-3 | 1271738-59-0 | 5mg | $231 | 2024-03-01 | Buy |
| TRC | M341040 | MI-3(Menin-MLLInhibitor) | 1271738-59-0 | 5mg | $185 | 2021-12-16 | Buy |
| ChemScene | CS-0772 | MI-3 99.73% | 1271738-59-0 | 10mg | $252 | 2021-12-16 | Buy |
MI-3 (Menin-MLL Inhibitor) Chemical Properties,Uses,Production
Description
MI-3 is an inhibitor of the interaction between menin and mixed lineage leukemia (MLL) fusion proteins (IC50 = 648 nM). MI-3 binds to menin (Kd = 201 nM) and inhibits the menin interaction with the MLL fusion protein MLL-AF9 in HEK293 cells without affecting protein levels of menin or MLL-AF9. It inhibits growth of mouse bone marrow cells (BMCs) expressing the Hoxa9 transformation-dependent MLL fusion proteins MLL-AF9 or MLL-ENL (IC50 = 5 μM for both), as well as reduces colony formation and induces differentiation of MLL-AF9-transformed BMCs. MI-3 inhibits growth of human leukemia cell lines containing MLL translocations and decreases the expression of the transcription factors HOXA9, HOXA10, and MEIS1 in THP-1 cells.
Uses
MI-3 (Menin-MLL Inhibitor) reverses oncogenic activity of MLL fusion proteins in leukemia.
MI-3 (Menin-MLL Inhibitor) Preparation Products And Raw materials
Raw materials
Preparation Products
MI-3 (Menin-MLL Inhibitor) Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 29220 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3136 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8474 | 58 |
| Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd | +86-18341751992 +86-15382112998 | 757984502@qq.com | China | 892 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |