3-QuinolinecarboxaMide, 1,2-dihydro-4-hydroxy-1-(2-Methylpropyl)-N-(5-Methyl-2-thiazolyl)-2-oxo-
- CAS No.
- 280112-24-5
- Chemical Name:
- 3-QuinolinecarboxaMide, 1,2-dihydro-4-hydroxy-1-(2-Methylpropyl)-N-(5-Methyl-2-thiazolyl)-2-oxo-
- Synonyms
- AMPK Signaling Activator IX, F17 - CAS 280112-24-5 - Calbiochem;3-QuinolinecarboxaMide, 1,2-dihydro-4-hydroxy-1-(2-Methylpropyl)-N-(5-Methyl-2-thiazolyl)-2-oxo-
- CBNumber:
- CB42627012
- Molecular Formula:
- C18H19N3O3S
- Molecular Weight:
- 357.43
- MDL Number:
- MOL File:
- 280112-24-5.mol
3-QuinolinecarboxaMide, 1,2-dihydro-4-hydroxy-1-(2-Methylpropyl)-N-(5-Methyl-2-thiazolyl)-2-oxo- price More Price(1)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
American Custom Chemicals Corporation | CHM0971071 | 1,2-DIHYDRO-4-HYDROXY-1-(2-METHYLPROPYL)-N-(5-METHYL-2-THIAZOLYL)-2-OXO-3-QUINOLINECARBOXAMIDE 95.00% | 280112-24-5 | 5MG | $502.28 | 2021-12-16 | Buy |
Product number | Packaging | Price | Buy |
---|---|---|---|
CHM0971071 | 5MG | $502.28 | Buy |
3-QuinolinecarboxaMide, 1,2-dihydro-4-hydroxy-1-(2-Methylpropyl)-N-(5-Methyl-2-thiazolyl)-2-oxo- Chemical Properties,Uses,Production
Definition
ChEBI: 4-hydroxy-1-isobutyl-N-(5-methyl-1,3-thiazol-2-yl)-2-oxoquinoline-3-carboxamide is a member of the class of quinolones that is the amide obtained from formal condensation of the carboxy group of 4-hydroxy-1-(2-methylpropyl)-2-oxo-1,2-dihydroquinoline-3-carboxylic acid with the amino group of 5-methyl-1,3-thiazol-2-amine. It is a monocarboxylic acid amide, a member of 1,3-thiazoles, a quinolone and a monohydroxyquinoline.
General Description
A cell-permeable 4-hydroxy-2-oxo quinoline carboxamide that acts as an agonist of AMPK signaling. It is shown to reduce fat storage in C. elegans (EC50 ~ 0.1 μM) and reduce the expression level of fat-7 (a C. elegans ortholog of mammalian stearoyl-CoA desaturase-1), through aak-1 (an ortholog for the AMPK-α1 catalytic subunit) and K08F8.2 (a transcription factor) dependent mechanisms. In addition, it markedly reduces the number of lipid droplets in HepG2 human hepatocarcinoma cells at 25 μM, and elicits the phosphorylation and inactivation of acetyl coenzyme A carboxylase (ACC, the enzyme that catalyzes the rate-limiting step in de novo fatty acid synthesis). F17-induced ACC phosphorylation can be abrogated by simultaneous treatment with an AMPK inhibitor compound C (Cat. No. 171260).
3-QuinolinecarboxaMide, 1,2-dihydro-4-hydroxy-1-(2-Methylpropyl)-N-(5-Methyl-2-thiazolyl)-2-oxo- Preparation Products And Raw materials
Raw materials
Preparation Products
3-QuinolinecarboxaMide, 1,2-dihydro-4-hydroxy-1-(2-Methylpropyl)-N-(5-Methyl-2-thiazolyl)-2-oxo- Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
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Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
Supplier | Advantage |
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Sigma-Aldrich | 80 |