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Omadacycline

CAS No.
389139-89-3
Chemical Name:
Omadacycline
Synonyms
OMadacycline;AMadacycline;PTK-796;PTK 0796;Omadacycline-D9;2H9]-Omadacycline;Omadacycline (PTK 0796;Amadacycline,Omadacycline,PTK 0796;OMADACYCLINE; PTK 0796; PTK-0796; PTK0796; AMADACYCLINE;(4S,4aS,5aR,12aS)-4,7-Bis(dimethylamino)-3,10,12,12a-tetrahydroxy-9-((neopentylamino)methyl)-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide
CBNumber:
CB42627315
Molecular Formula:
C29H40N4O7
Molecular Weight:
556.65
MDL Number:
MFCD19443723
MOL File:
389139-89-3.mol
Last updated:2023-12-19 14:23:31

Omadacycline Properties

Boiling point 837.6±65.0 °C(Predicted)
Density 1.39±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO:1.0(Max Conc. mg/mL);1.8(Max Conc. mM)
form A crystalline solid
pka 4.50±1.00(Predicted)
Stability Hygroscopic
FDA UNII 090IP5RV8F
ATC code J01AA15

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictograms
GHS07,GHS08
Signal word  Warning
Hazard statements  H361-H302
Precautionary statements  P201-P202-P281-P308+P313-P405-P501-P264-P270-P301+P312-P330-P501
NFPA 704
0
2 0

Omadacycline price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC O633020 Omadacycline 389139-89-3 25mg $1050 2021-12-16 Buy
ApexBio Technology A3171 Amadacycline 389139-89-3 50mg $1178 2021-12-16 Buy
ApexBio Technology A3171 Amadacycline 389139-89-3 200mg $2674 2021-12-16 Buy
ApexBio Technology A3171 Amadacycline 389139-89-3 5mg $339 2021-12-16 Buy
ApexBio Technology A3171 Amadacycline 389139-89-3 10mg $437 2021-12-16 Buy
Product number Packaging Price Buy
O633020 25mg $1050 Buy
A3171 50mg $1178 Buy
A3171 200mg $2674 Buy
A3171 5mg $339 Buy
A3171 10mg $437 Buy

Omadacycline Chemical Properties,Uses,Production

Description

Omadacycline, the drug that US FDA approved for the treatment of community-acquired bacterial pneumonia and acute bacterial skin and skin structure infections. It is not susceptible to common tetracycline-resistancemechanisms, and has demonstrated efficacy against a broad spectrum of pathogens including resistant isolates, which are increasing in prevalence and complexity.

Uses

Omadacycline is a potent an demonstrates efficacy against both Bacillus anthracis and Yersinia pestis; Also, it is a novel aminomethylcycline antibiotic in clinical development for community-acquired bacterial pneumonia (CABP).

Definition

ChEBI: Omadacycline is a member of tetracyclines.

Pharmacology

Omadacycline has shown clinical efficacy in anaerobic acute bacterial skin and skin structure infections (ABSSSI) and in animal models of intra-abdominal anaerobic infections.The in vitro activity of Omadacycline against clinically relevant anaerobes was similar to that of tigecycline, with MIC90 values of 1 to 8 g/ml against Bacteroides spp, 0.5 g/ml against Clostridium difficile, Prevotella spp., and Porphyromonas asaccharolytica,1 g/ml against Peptostreptococcus spp, and 16 g/ml against Clostridium perfringens.

Side effects

OMadacycline may cause serious adverse reactions including hypersensitivity reactions, tooth discoloration,Clostridioides difficile-associated diarrhea, and reversible inhibition of bone growth when administered during the second and third trimesters of pregnancy.Common adverse reactions include nausea, vomiting, infusion site reactions, alanine aminotransferase increased, aspartate aminotransferase increased, gamma-glutamyl transferase increased, hypertension, headache, diarrhea, insomnia, and constipation.Mild to moderate nausea and vomiting were the most frequent treatment-emergent adverse events in omadacycline (111 [30%] of 368 and 62 [17%] of 368, respectively) groups.

Omadacycline Preparation Products And Raw materials

Raw materials

Preparation Products

Omadacycline Suppliers

Global( 76)Suppliers
Supplier Tel Email Country ProdList Advantage
BOC Sciences
+1-631-485-4226 inquiry@bocsci.com United States 19553 58
Shenzhen Excellent Biotech Co., Ltd.
13480692018 ramyan@ex-biotech.com CHINA 954 58
Career Henan Chemica Co
+86-0371-86658258 15093356674; laboratory@coreychem.com China 30256 58
InvivoChem
+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6393 58
TargetMol Chemicals Inc.
+1-781-999-5354 support@targetmol.com United States 19973 58
Shanghai Hengmao New Materials Technology CO., LIMITED
+86-0086-1773693-3208 +8617736933208 1137059254@qq.com China 9287 58
GIHI CHEMICALS CO.,LIMITED
+8618058761490 info@gihichemicals.com China 50001 58
Wuhan Topule Biopharmaceutical Co., Ltd
+8618327326525 masar@topule.com China 8475 58
LEAPCHEM CO., LTD.
+86-852-30606658 market18@leapchem.com China 43348 58
Amadis Chemical Company Limited
571-89925085 sales@amadischem.com China 132020 58

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Omadacycline Spectrum

PTK 0796 PTK-796 OMADACYCLINE; PTK 0796; PTK-0796; PTK0796; AMADACYCLINE 2-Naphthacenecarboxamide, 4,7-bis(dimethylamino)-9-[[(2,2-dimethylpropyl)amino]methyl]-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-, (4S,4aS,5aR,12aS)- Omadacycline-D9 AMadacycline OMadacycline Amadacycline,Omadacycline,PTK 0796 2H9]-Omadacycline Omadacycline (PTK 0796 spectrum,antibacterial,pathogens,Omadacycline,synthesis,Inhibitor,urinary,community-acquired,PTK-0796,skin-structure,anaerobic,acute,protein,pneumonia,tetracycline,inhibit,skin,Gram-negative,atypical,Antibiotic,Gram-positive,tract,PTK0796,broad,Bacterial,infections,agent (4S,4aS,5aR,12aS)-4,7-Bis(dimethylamino)-3,10,12,12a-tetrahydroxy-9-((neopentylamino)methyl)-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide 389139-89-3 C29H40N4O7