BIX-02565
- CAS No.
- 1311367-27-7
- Chemical Name:
- BIX-02565
- Synonyms
- CS-2569;BIX-02565;BIX-02565;BIX02565;Inhibitor,BIX02565,BIX-02565,Ribosomal S6 Kinase (RSK),S6K,BIX 02565,inhibit;(5R)-N-[1-[3-(Dimethylamino)propyl]-1H-benzimidazol-2-yl]-2,3,4,5-tetrahydro-5-methyl-1-oxo-1H-[1,4]diazepino[1,2-a]indole-8-carboxamide;1H-[1,4]Diazepino[1,2-a]indole-8-carboxamide, N-[1-[3-(dimethylamino)propyl]-1H-benzimidazol-2-yl]-2,3,4,5-tetrahydro-5-methyl-1-oxo-, (5R)-
- CBNumber:
- CB42627603
- Molecular Formula:
- C26H30N6O2
- Molecular Weight:
- 458.56
- MDL Number:
- MFCD25976796
- MOL File:
- 1311367-27-7.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
|||||||||
---|---|---|---|---|---|---|---|---|---|---|
Signal word | Warning | |||||||||
NFPA 704 |
|
BIX-02565 price More Price(21)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Cayman Chemical | 19183 | BIX 02565 ≥98% | 1311367-27-7 | 500μg | $36 | 2024-03-01 | Buy |
Cayman Chemical | 19183 | BIX 02565 ≥98% | 1311367-27-7 | 1mg | $66 | 2024-03-01 | Buy |
Cayman Chemical | 19183 | BIX 02565 ≥98% | 1311367-27-7 | 5mg | $223 | 2024-03-01 | Buy |
ChemScene | CS-1659 | BIX02565 99.33% | 1311367-27-7 | 5mg | $228 | 2021-12-16 | Buy |
Adipogen Life Sciences | SYN-1228-M005 | BIX02565 ≥95% | 1311367-27-7 | 5mg | $205 | 2021-12-16 | Buy |
BIX-02565 Chemical Properties,Uses,Production
Biological Activity
bix 02565 is a novel inhibitor of ribosomal s6 kinase 2 with ic50 value of 1 nm [1].ribosomal s6 kinase (rsk) is a na/h exchanger (nhe) -activating factor and is important for ph maintenance during the early phase of cellular stress. while, nhe activation leads to ca2+ overload and cardiac hypertrophy over longer periods [2].bix 02565 is a novel rsk2 inhibitor. also, bix 02565 inhibited adrenergic ɑ1a-, ɑ1b-, ɑ1d-, ɑ2a-, β2- and imidazoline i2 receptors with ic50 values ranging from 0.052 to 1.820 μm. these receptors played important roles in the regulation of vascular tone and cardiac function [2]. also, bix 02565 inhibited lrrk2 and prkd1 with ic50 values of 16 and 35 nm [1].in the rat cv screen, bix 02565 (1, 3 and 10 mg/kg) significantly decreased heart rate (-93 +13 beats/min) and mean arterial pressure (map: to -65 +6 mm hg below baseline). in telemetry-instrumented rats, bix 02565 (30, 100 and 300 mg/kg for 4 days) reduced map (to -39 + 4 mm hg) in a concentration-dependent way [2].
References
[1]. kirrane tm, boyer sj, burke j, et al. indole rsk inhibitors. part 2: optimization of cell potency and kinase selectivity. bioorg med chem lett, 2012, 22(1): 738-742.
[2]. fryer rm, muthukumarana a, chen rr, et al. mitigation of off-target adrenergic binding and effects on cardiovascular function in the discovery of novel ribosomal s6 kinase 2 inhibitors. j pharmacol exp ther, 2012, 340(3): 492-500.
BIX-02565 Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 132020 | 58 |
Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 7553 | 61 |
Jinan Mingya Medical Technology Co., Ltd. | 0531-85828981 | 864598798@qq.com | China | 588 | 58 |
AdooQ Bioscience CHINA | 025-58849295 18951903616; | info@adooq.cn | China | 2989 | 60 |
LETOPHARM LIMITED | +86-21-5821 5861 | sales@letopharm.com | China | 2384 | 58 |
Chengdu YouSuo Biotechnology Limited | 13693449011 | 83948782@qq.com | China | 92 | 50 |