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BIX-02565

CAS No.
1311367-27-7
Chemical Name:
BIX-02565
Synonyms
CS-2569;BIX-02565;BIX-02565;BIX02565;Inhibitor,BIX02565,BIX-02565,Ribosomal S6 Kinase (RSK),S6K,BIX 02565,inhibit;(5R)-N-[1-[3-(Dimethylamino)propyl]-1H-benzimidazol-2-yl]-2,3,4,5-tetrahydro-5-methyl-1-oxo-1H-[1,4]diazepino[1,2-a]indole-8-carboxamide;1H-[1,4]Diazepino[1,2-a]indole-8-carboxamide, N-[1-[3-(dimethylamino)propyl]-1H-benzimidazol-2-yl]-2,3,4,5-tetrahydro-5-methyl-1-oxo-, (5R)-
CBNumber:
CB42627603
Molecular Formula:
C26H30N6O2
Molecular Weight:
458.56
MDL Number:
MFCD25976796
MOL File:
1311367-27-7.mol
MSDS File:
SDS
Last updated:2023-06-08 09:02:36

BIX-02565 Properties

Density 1.32±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility ≥22.95 mg/mL in DMSO; insoluble in H2O; ≥3.17 mg/mL in EtOH with gentle warming and ultrasonic
form Powder
pka 12.30±0.40(Predicted)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
NFPA 704
0
2 0

BIX-02565 price More Price(21)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 19183 BIX 02565 ≥98% 1311367-27-7 500μg $36 2024-03-01 Buy
Cayman Chemical 19183 BIX 02565 ≥98% 1311367-27-7 1mg $66 2024-03-01 Buy
Cayman Chemical 19183 BIX 02565 ≥98% 1311367-27-7 5mg $223 2024-03-01 Buy
ChemScene CS-1659 BIX02565 99.33% 1311367-27-7 5mg $228 2021-12-16 Buy
Adipogen Life Sciences SYN-1228-M005 BIX02565 ≥95% 1311367-27-7 5mg $205 2021-12-16 Buy
Product number Packaging Price Buy
19183 500μg $36 Buy
19183 1mg $66 Buy
19183 5mg $223 Buy
CS-1659 5mg $228 Buy
SYN-1228-M005 5mg $205 Buy

BIX-02565 Chemical Properties,Uses,Production

Biological Activity

bix 02565 is a novel inhibitor of ribosomal s6 kinase 2 with ic50 value of 1 nm [1].ribosomal s6 kinase (rsk) is a na/h exchanger (nhe) -activating factor and is important for ph maintenance during the early phase of cellular stress. while, nhe activation leads to ca2+ overload and cardiac hypertrophy over longer periods [2].bix 02565 is a novel rsk2 inhibitor. also, bix 02565 inhibited adrenergic ɑ1a-, ɑ1b-, ɑ1d-, ɑ2a-, β2- and imidazoline i2 receptors with ic50 values ranging from 0.052 to 1.820 μm. these receptors played important roles in the regulation of vascular tone and cardiac function [2]. also, bix 02565 inhibited lrrk2 and prkd1 with ic50 values of 16 and 35 nm [1].in the rat cv screen, bix 02565 (1, 3 and 10 mg/kg) significantly decreased heart rate (-93 +13 beats/min) and mean arterial pressure (map: to -65 +6 mm hg below baseline). in telemetry-instrumented rats, bix 02565 (30, 100 and 300 mg/kg for 4 days) reduced map (to -39 + 4 mm hg) in a concentration-dependent way [2].

References

[1]. kirrane tm, boyer sj, burke j, et al. indole rsk inhibitors. part 2: optimization of cell potency and kinase selectivity. bioorg med chem lett, 2012, 22(1): 738-742.
[2]. fryer rm, muthukumarana a, chen rr, et al. mitigation of off-target adrenergic binding and effects on cardiovascular function in the discovery of novel ribosomal s6 kinase 2 inhibitors. j pharmacol exp ther, 2012, 340(3): 492-500.

BIX-02565 Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 57)Suppliers
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ATK CHEMICAL COMPANY LIMITED
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HANGZHOU CLAP TECHNOLOGY CO.,LTD
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InvivoChem
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TargetMol Chemicals Inc.
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Amadis Chemical Company Limited
571-89925085 sales@amadischem.com China 132020 58
Haoyuan Chemexpress Co., Ltd. 021-58950125 info@chemexpress.com China 7553 61
Jinan Mingya Medical Technology Co., Ltd. 0531-85828981 864598798@qq.com China 588 58
AdooQ Bioscience CHINA 025-58849295 18951903616; info@adooq.cn China 2989 60
LETOPHARM LIMITED +86-21-5821 5861 sales@letopharm.com China 2384 58
Chengdu YouSuo Biotechnology Limited 13693449011 83948782@qq.com China 92 50

BIX-02565 Spectrum

BIX-02565 (5R)-N-[1-[3-(Dimethylamino)propyl]-1H-benzimidazol-2-yl]-2,3,4,5-tetrahydro-5-methyl-1-oxo-1H-[1,4]diazepino[1,2-a]indole-8-carboxamide CS-2569 BIX-02565;BIX02565 Inhibitor,BIX02565,BIX-02565,Ribosomal S6 Kinase (RSK),S6K,BIX 02565,inhibit 1H-[1,4]Diazepino[1,2-a]indole-8-carboxamide, N-[1-[3-(dimethylamino)propyl]-1H-benzimidazol-2-yl]-2,3,4,5-tetrahydro-5-methyl-1-oxo-, (5R)- 1311367-27-7