ST 2825
- CAS No.
- 894787-30-5
- Chemical Name:
- ST 2825
- Synonyms
- ST 2825;ST 2825;ST2825;(2R,4'R,8a'R)-1-(2-(4-(2-(2,4-Dichlorophenoxy)acetamido)phenyl)acetyl)-6'-oxotetrahydro-2'H,6'H-spiro[pyrrolidine-2,7'-pyrrolo[2,1-b][1,3]thiazine]-4'-carboxamide;(2R,4'R,8'aR)-1-[2-[4-[[2-(2,4-Dichlorophenoxy)acetyl]amino]phenyl]acetyl]tetrahydro-6'-oxospiro[pyrrolidine-2,7'(6'H)-[2H]pyrrolo[2,1-b][1,3]thiazine]-4'-carboxamide;Spiro[pyrrolidine-2,7'(6'H)-[2H]pyrrolo[2,1-b][1,3]thiazine]-4'-carboxamide, 1-[2-[4-[[2-(2,4-dichlorophenoxy)acetyl]amino]phenyl]acetyl]tetrahydro-6'-oxo-, (2R,4'R,8'aR)-
- CBNumber:
- CB42628433
- Molecular Formula:
- C27H28Cl2N4O5S
- Molecular Weight:
- 591.51
- MDL Number:
- MFCD30207830
- MOL File:
- 894787-30-5.mol
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
ST 2825 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0797 | ST2825 99.86% | 894787-30-5 | 1mg | $426 | 2021-12-16 | Buy |
| ApexBio Technology | A3840 | ST2825 | 894787-30-5 | 1mg | $520 | 2021-12-16 | Buy |
| ChemScene | CS-0797 | ST2825 99.86% | 894787-30-5 | 5mg | $1464 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb611397 | ST-2825 | 894787-30-5 | 5mg | $1470.5 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb611397 | ST-2825 | 894787-30-5 | 10mg | $2223.6 | 2021-12-16 | Buy |
ST 2825 Chemical Properties,Uses,Production
Biological Activity
st 2825 is a specific inhibitor of myd88 dimerization [1].st 2825 is a synthetic compound which mimics the structure of the heptapeptide in the bb-loop of the myd88-tir domain and interferes the homodimerization of myd88. st 2825 was proved to specifically inhibit the homodimerization of myd88 tir domains without affecting the homodimerization of death domains. in hek293t cells transfected with flag-myd88 and myc-myd88, st 2825 inhibited the interaction of the two myd88 by 80% at the concentration of 10 μm. this inhibition resulted in the subsequent interference of the irak1 and irak4 recruitment. besides that, administration of st 2825 significantly inhibited the il-6 production stimulated by il-1β at doses of 100 and 200 mg/kg in mice. furthermore, 8 μm st 2825 completely blocked the tlr9-induced b cell proliferation. st2825 also suppressed the generation of plasma cells induced by cpg dose-dependently [1].
target
MyD88
References
[1] loiarro m, capolunghi f, fantò n, et al. pivotal advance: inhibition of myd88 dimerization and recruitment of irak1 and irak4 by a novel peptidomimetic compound. journal of leukocyte biology, 2007, 82(4): 801-810.
ST 2825 Preparation Products And Raw materials
ST 2825 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49739 | 58 |
| HangZhou RunYan Pharma Technology Co.,LTD. | +86-88660901 +86-18112526015 | sales@runyanpharma.com | China | 326 | 58 |
| Jilin Chinese Academy of Sciences-yanshen Technology | +undefined18143011203 | info@chemextension.com | China | 42057 | 58 |
| Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 7553 | 61 |
| MedChemexpress LLC | 021-58955995 | sales@medchemexpress.cn | United States | 4863 | 58 |
| ShangHai Caerulum Pharma Discovery Co., Ltd. | 18149758185 | sales-cpd@caerulumpharma.com | China | 3420 | 58 |
| SPIRO PHARMA | eric_feng1954@126.com | China | 9254 | 55 | |
| Guangzhou QiYun Biotechnology Co., Ltd. | 020-61288194 61288195 | 505721671@qq.com | China | 3868 | 58 |
| Beijing Solarbio Science & Tecnology Co., Ltd. | 010-50973130 4009686088 | 3193328036@qq.com | China | 29797 | 68 |