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CZC-25146 hydrochloride

CZC-25146 hydrochloride Structure
CZC-25146 hydrochloride structure
CAS No.
1330003-04-7
Chemical Name:
CZC-25146 hydrochloride
Synonyms
CS-1074;CS-1206;CZC-25146.HCl;CZC-25146 hydrochL;CZC-25146 hydrochloride;CZC-25146 hydrochloride >=98% (HPLC);CZC-25146; CZC 25146; CZC25146;CZC25146 HYDROCHLORIDE;CZC 25146 HYDROCHLORIDE;N-[2-[[5-Fluoro-2-[[2-Methoxy-4-(4-Morpholinyl)phenyl]aMino]-4-pyriMidinyl]aMino]phenyl]-MethanesulfonaMide hydrochloride;CZC-25146.HCL;N-[2-[[5-FLUORO-2-[[2-METHOXY-4-(4-MORPHOLINYL)PHENYL]AMINO]-4-PYRIMIDINYL]AMINO]PHENYL]-METHANESULFONAMIDE HYDROCHLORIDE;Leucine-rich repeat kinase 2,CZC25146,neurons,LRRK2 G2019S,CZC 25146,Inhibitor,liver diseases,inflammatory,Parkinson's disease,LRRK2,inhibit,CZC-25146,CZC 25146 hydrochloride,CZC25146 hydrochloride
CBNumber:
CB42630076
Molecular Formula:
C22H26ClFN6O4S
Molecular Weight:
524.9960432
MDL Number:
MFCD22417347
MOL File:
1330003-04-7.mol
Last updated:2025-04-17 18:22:24
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CZC-25146 hydrochloride Properties

storage temp. 2-8°C
solubility DMSO: >15mg/mL (warmed)
form powder
color white to beige

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS06
Signal word  Danger
Hazard statements  H301-H319
Precautionary statements  P301+P310-P305+P351+P338
Hazard Codes  T,Xi
Risk Statements  25-36
Safety Statements  26-45
RIDADR  UN 2811 6.1 / PGIII
WGK Germany  3

CZC-25146 hydrochloride price More Price(2)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Crysdot CD31003869 CZC-25146 hydrochloride 98+% 1330003-04-7 5mg $79 2021-12-16 Buy
Crysdot CD31003869 CZC-25146 hydrochloride 98+% 1330003-04-7 50mg $603 2021-12-16 Buy
Product number Packaging Price Buy
CD31003869 5mg $79 Buy
CD31003869 50mg $603 Buy

CZC-25146 hydrochloride Chemical Properties,Uses,Production

Uses

N-(2-(2-(2-Methoxy-4-morpholinophenylamino)-5-fluoropyrimidin-4-ylamino)phenyl)methanesulfonamide is a compound that acts as an inhibitor of LRRK2, a factor in the expression of Parkinsons’s disease, and is ATP-competitive.

in vivo

CZC-25146 (1 mg/kg for i.v.; 5 mg/kg for p.o.; single dosage) exhibits relatively good pharmacokinetic properties and an extensive distribution throughout animal body following intravenous injection into mice[1].
CZC-25146 (250 mg/kg; p.o.; 14 days) reduces the ATZ polymer levels in over expressing human polymeric ATZ mice[3].

Animal Model:Male CD-1 mice[1]
Dosage:1 mg/kg for i.v.; 5 mg/kg for p.o.
Administration:i.v. and p.o.; single dosage
Result:Pharmacokinetic Parameters of CZC-25146 in male CD-1 mice[1].
i.v. (1 mg/kg)p.o. (5 mg/kg)
CL (L/h/kg)2.3
Vss (L/kg)5.4
t1/2 (h)1.61
tmax (h)00.25
Cmax (ng/mL)1541357
AUClast (ng/mL·h)4192878
AUCinf (ng/mL·h)4342894
F (%)133
Animal Model:Genetically modified male mice (6 weeks; over expressing human polymeric ATZ)[3]
Dosage:250 mg/kg
Administration:p.o.; 14 days
Result:Dramatically and reproducibly reduced the ATZ polymer levels with an overall reduction from 60% in the control group to 37%

CZC-25146 hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

CZC-25146 hydrochloride Suppliers

Global( 37)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
Tianjin Xinshengjiahe Science & Technology Development Co,.Ltd 		+86-86-22-87899925 +86-8618522618860 18522618860@163.com China 694 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32159 58
Career Henan Chemica Co 		+86-0371-86658258 +8613203830695 laboratory@coreychem.com China 30231 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6391 58
TargetMol Chemicals Inc. 		support@targetmol.com United States 38630 58
Amadis Chemical Company Limited 		571-89925085 sales@amadischem.com China 131957 58
Chembest Research Laboratories Limited +86-21-20908456 sales@BioChemBest.com China 6005 61
SHANGHAI FORTUNE CHEMICAL TECHNOLOGY CO., LTD 13816107857 sales@fortunechem-sh.com China 825 58
AdooQ BioScience, LLC +1 (866) 930-6790 info@adooq.com United States 2782 58
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 		60
Tianjin Xinshengjiahe Science & Technology Development Co,.Ltd 		58
TargetMol Chemicals Inc. 		58
Career Henan Chemica Co 		58
InvivoChem 		58
TargetMol Chemicals Inc. 		58
Amadis Chemical Company Limited 		58
Chembest Research Laboratories Limited 61
SHANGHAI FORTUNE CHEMICAL TECHNOLOGY CO., LTD 58
AdooQ BioScience, LLC 58

View Lastest Price from CZC-25146 hydrochloride manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
CZC-25146 hydrochloride pictures 2024-11-19 CZC-25146 hydrochloride
1330003-04-7
 US $30.00-119.00 / mg 99.06% 10g TargetMol Chemicals Inc.
CZC-25146 hydrochloride CZC-25146.HCl CZC-25146.HCL;N-[2-[[5-FLUORO-2-[[2-METHOXY-4-(4-MORPHOLINYL)PHENYL]AMINO]-4-PYRIMIDINYL]AMINO]PHENYL]-METHANESULFONAMIDE HYDROCHLORIDE N-[2-[[5-Fluoro-2-[[2-Methoxy-4-(4-Morpholinyl)phenyl]aMino]-4-pyriMidinyl]aMino]phenyl]-MethanesulfonaMide hydrochloride CS-1206 CS-1074 CZC-25146; CZC 25146; CZC25146;CZC25146 HYDROCHLORIDE;CZC 25146 HYDROCHLORIDE CZC-25146 hydrochL CZC-25146 hydrochloride >=98% (HPLC) Leucine-rich repeat kinase 2,CZC25146,neurons,LRRK2 G2019S,CZC 25146,Inhibitor,liver diseases,inflammatory,Parkinson's disease,LRRK2,inhibit,CZC-25146,CZC 25146 hydrochloride,CZC25146 hydrochloride 1330003-04-7