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N-(2-(4'-cyanobiphenyl-4-yl)propyl)propane-2-sulfonaMide

N-(2-(4'-cyanobiphenyl-4-yl)propyl)propane-2-sulfonaMide structure

CAS No.: 211311-95-4

Chemical Name:: N-(2-(4'-cyanobiphenyl-4-yl)propyl)propane-2-sulfonaMide

Synonyms: 100775;CS-2739;LY40418;LY404187;LY-404187; LY 404187;N-(2-(4'-cyanobiphenyl-4-yl)propyl)propane-2-sulfonaMide;N-2-(4-(4-Cyanophenyl)phenyl)propyl-2-propanesulfonamide;N-(2-(4'-cyanobiphenyl-4-yl)propyl)propane-2-sulfonamide;N-[2-[4-(4-Cyanophenyl)phenyl]propyl]propane-2-sulfonamide;N-[2-(4'-Cyano[1,1'-biphenyl]-4-yl)propyl]-2-propanesulfonamide

CBNumber:: CB42640286

Molecular Formula:: C19H22N2O2S

Molecular Weight:: 342.46

MDL Number:: MFCD07364003

MOL File:: 211311-95-4.mol

MSDS File:: SDS

Last updated:2023-09-04 16:42:00

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N-(2-(4'-cyanobiphenyl-4-yl)propyl)propane-2-sulfonaMide Properties

Boiling point	519.0±60.0 °C(Predicted)
Density	1.19±0.1 g/cm3(Predicted)
storage temp.	Sealed in dry,Room Temperature
solubility	DMF: 15mg/mL; DMSO: 15mg/mL; DMSO:PBS (pH 7.2) (1:4): 0.2mg/mL; Ethanol: 3mg/mL
form	A solid
pka	11.24±0.40(Predicted)
FDA UNII	75W6I8W6OU

N-(2-(4'-cyanobiphenyl-4-yl)propyl)propane-2-sulfonaMide price More Price(23)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	28741	LY404187	211311-95-4	5mg	$110	2024-03-01	Buy
Cayman Chemical	28741	LY404187	211311-95-4	50mg	$542	2024-03-01	Buy
Cayman Chemical	28741	LY404187	211311-95-4	10mg	$175	2024-03-01	Buy
Cayman Chemical	28741	LY404187	211311-95-4	25mg	$352	2024-03-01	Buy
Tocris	5297	LY404187 ≥98%(HPLC)	211311-95-4	10	$210	2021-12-16	Buy

Product number	Packaging	Price	Buy
28741	5mg	$110	Buy
28741	50mg	$542	Buy
28741	10mg	$175	Buy
28741	25mg	$352	Buy
5297	10	$210	Buy

N-(2-(4'-cyanobiphenyl-4-yl)propyl)propane-2-sulfonaMide Chemical Properties,Uses,Production

Description

LY404187 is a benzothiadiazide positive allosteric modulator of AMPA receptors. It increases glutamate-induced activation of GluR1_i, -2_i, -2_o, -3_i, and -4_i subunit-containing AMPA receptors with EC₅₀ values of 5.65, 0.15, 1.44, 1.66, and 0.21 μM, respectively, in a calcium influx assay. LY404187 is selective for these AMPA receptors over GluR6 subunit-containing kainate receptors at 10 μM. LY404187 increases currents induced by glutamate and AMPA in rat prefrontal cortex pyramidal neurons (EC₅₀s = 1.3 and 1.2 μM, respectively) but not in AMPA-stimulated primary rat embryonic hippocampal or primary cerebellar Purkinje neurons. LY404187 prevents decreases in the number of dopaminergic neurons in the substantia nigra induced by MPTP and 6-OHDA in mouse and rat, respectively, models of Parkinson’s disease when administered at a dose of 0.5 mg/kg per day.

Uses

LY 404187 is a novel positive allosteric modulator of AMPA receptors.

storage

Store at +4°C

N-(2-(4'-cyanobiphenyl-4-yl)propyl)propane-2-sulfonaMide Preparation Products And Raw materials

Raw materials

Preparation Products

N-(2-(4'-cyanobiphenyl-4-yl)propyl)propane-2-sulfonaMide Suppliers

Global( 60)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Career Henan Chemica Co	+86-0371-86658258 15093356674;	laboratory@coreychem.com	China	30255	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
TargetMol Chemicals Inc.	+1-781-999-5354	support@targetmol.com	United States	19973	58
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	52927	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131981	58
Shanghai Boyle Chemical Co., Ltd.		sales@boylechem.com	China	2923	55
ChemShuttle, Inc.	0510-83588313-802 18800520310;	sales@chemshuttle.com	China	3062	62
AdooQ BioScience, LLC	+1 (866) 930-6790	info@adooq.com	United States	2784	58
CEG Chemical Science&Technology Co., Ltd.	Mobile:13665161512		China	1785	58
Shanghai HuanChuan Industry Co.,Ltd.	021-61478794	sales@hcshhai.com	China	9798	50

Supplier	Advantage
Career Henan Chemica Co	58
InvivoChem	58
TargetMol Chemicals Inc.	58
Aladdin Scientific	58
Amadis Chemical Company Limited	58
Shanghai Boyle Chemical Co., Ltd.	55
ChemShuttle, Inc.	62
AdooQ BioScience, LLC	58
CEG Chemical Science&Technology Co., Ltd.	58
Shanghai HuanChuan Industry Co.,Ltd.	50

N-(2-(4'-cyanobiphenyl-4-yl)propyl)propane-2-sulfonaMide Spectrum

N-(2-(4'-cyanobiphenyl-4-yl)propyl)propane-2-sulfonaMide(211311-95-4)¹HNMR

211311-95-4(N-(2-(4'-cyanobiphenyl-4-yl)propyl)propane-2-sulfonaMide)Related Search:

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BMS-986205 Budiodarone tartrate COH-29

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N-(2-(4'-cyanobiphenyl-4-yl)propyl)propane-2-sulfonaMide LY404187 N-(2-(4'-Cyano-[1,1'-biphenyl]-4-yl)propyl)propane-2-sulfonaMide N-[2-(4'-Cyano[1,1'-biphenyl]-4-yl)propyl]-2-propanesulfonamide N-2-(4-(4-Cyanophenyl)phenyl)propyl-2-propanesulfonamide LY-404187 N-(2-(4'-cyanobiphenyl-4-yl)propyl)propane-2-sulfonaMide CS-2739 100775 LY-404187; LY 404187 2-Propanesulfonamide, N-[2-(4'-cyano[1,1'-biphenyl]-4-yl)propyl]- N-[2-[4-(4-Cyanophenyl)phenyl]propyl]propane-2-sulfonamide GluR2o,inhibit,Allosteric,GluR3i,iGluR,GluR4i,AMPA,Ionotropic glutamate receptors,GluR1i,LY-404187,psychiatric,LY404187,Inhibitor,GluR2i,LY 404187,neurodegenerative LY40418 N-(2-(4'-cyanobiphenyl-4-yl)propyl)propane-2-sulfonamide 211311-95-4