DANSYLCADAVERINE
- CAS No.
- 10121-91-2
- Chemical Name:
- DANSYLCADAVERINE
- Synonyms
- 5-
- CBNumber:
- CB4266400
- Molecular Formula:
- C17H25N3O2S
- Molecular Weight:
- 335.46
- MDL Number:
- MFCD00042704
- MOL File:
- 10121-91-2.mol
Melting point | 137-140 °C |
---|---|
Boiling point | 505.5±60.0 °C(Predicted) |
Density | 1.190±0.06 g/cm3(Predicted) |
storage temp. | −20°C |
pka | 11.96±0.50(Predicted) |
form | powder |
color | Yellow to yellowish green |
λmax | 335 nm |
BRN | 2951070 |
Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or methanol may be stored at -20°C for up to 1 month. |
Biological Applications | Measuring cardiac autophagic flux; treating cataract,fibrosis,Parkinson’s disease,peritoneal ovarian tumor dissemination,respiratory diseases,lung diseases,Huntington’s disease,spinobulbar atrophy,spinocerebellar ataxia,denta |
FDA UNII | I9N81SC5HD |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
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Signal word | Warning | |||||||||
Hazard statements | H315-H319-H335 | |||||||||
Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
Hazard Codes | Xi | |||||||||
Risk Statements | 36/37/38 | |||||||||
Safety Statements | 26-36 | |||||||||
WGK Germany | 3 | |||||||||
F | 10-23 | |||||||||
NFPA 704 |
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DANSYLCADAVERINE price More Price(20)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | 30432 | Dansylcadaverine BioReagent, suitable for fluorescence, ≥99.0% (HPLC) | 10121-91-2 | 100mg | $50.2 | 2024-03-01 | Buy |
Sigma-Aldrich | 30432 | Dansylcadaverine BioReagent, suitable for fluorescence, ≥99.0% (HPLC) | 10121-91-2 | 1g | $252 | 2024-03-01 | Buy |
Cayman Chemical | 15571 | Monodansylcadaverine ≥95% | 10121-91-2 | 100mg | $29 | 2024-03-01 | Buy |
Cayman Chemical | 15571 | Monodansylcadaverine ≥95% | 10121-91-2 | 250mg | $58 | 2024-03-01 | Buy |
Sigma-Aldrich | D4008 | Dansylcadaverine ≥97% (TLC) | 10121-91-2 | 100mg | $44 | 2024-03-01 | Buy |
DANSYLCADAVERINE Chemical Properties,Uses,Production
Description
Monodansylcadaverine (MDC) is a fluorescent marker for autophagic vacuoles. It is an autofluorescent substance incorporated into multilamellar bodies by both an ion trapping mechanism and interaction with membrane lipids, exhibiting a Stokes shift and increased relative fluorescence in hydrophobic environments. MDC selectively accumulates in PaTu 8902 subcellular fractions containing the lysosomal enzymes acid phosphatase and cathepsin D, but not those containing the rough and smooth endoplasmic reticulum markers TRAM and cytochrome P450, respectively.
Uses
Lysosomotropic fluorescent Probe
Uses
Fluorescent substrate for the assay of transamidating enzymes.
Uses
Dansylcadaverine is a fluorescent amine probe, which is believed to directly inhibit vesicular transport. Studies indicate that Dansylcadaverine can act as a marker used to study autophagy in the cytoplasm and vacuoles of plants and mammalian cells.
Definition
ChEBI: Monodansylcadaverine is a sulfonamide obtained by formal condensation of the sulfo group of 5-(dimethylamino)naphthalene-1-sulfonic acid with one of the amino groups of cadaverine. It has a role as a fluorochrome, a protective agent and an EC 2.3.2.13 (protein-glutamine gamma-glutamyltransferase) inhibitor. It is a sulfonamide, an aminonaphthalene, a tertiary amino compound and a primary amino compound. It is functionally related to a cadaverine.
References
1) Munafo and Colombo (2001),?A novel assay to study autophagy: regulation of autophagosome vacuole size by amino acid deprivation; Int. J. Cell Sci.,?114?3619 2) Jiang?et al. (2012),?Targeting androgen receptor leads to suppression of prostate cancer via induction of autophagy; J. Urol.,?188?1361 3) Haigler?et al.?(1980),?Dansylcadaverine inhibits internalization of 125I-epidermal growth factor in BALB 3T3 cells; J. Biol. Chem., 255 1239 4) Murthy?et al. (1994),?Residue Gln-30 of human erythrocyte anion transporter is a prime site for reaction with intrinsic transglutaminase; J. Biol. Chem.,?269?22907
DANSYLCADAVERINE Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3620 | 58 |
CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 47465 | 58 |
career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
Alfa Chemistry | +1-5166625404 | Info@alfa-chemistry.com | United States | 21317 | 58 |
LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
Shanghai Acmec Biochemical Technology Co., Ltd. | +undefined18621343501 | product@acmec-e.com | China | 33349 | 58 |
Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
Beijing Ouhe Technology Co., Ltd | 010-82967028 13552068683 | 2355560935@qq.com | China | 12426 | 60 |
View Lastest Price from DANSYLCADAVERINE manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2020-01-05 | DANSYLCADAVERINE
10121-91-2
|
US $1.00 / KG | 1KG | 95-99% | 1ton | Career Henan Chemical Co |
- DANSYLCADAVERINE
10121-91-2
- US $1.00 / KG
- 95-99%
- Career Henan Chemical Co