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VS-5584

VS-5584 structure

CAS No.: 1246560-33-7

Chemical Name:: VS-5584

Synonyms: SB-2343;VS-5584 (SB2343);SB2343;CS-875;SB 2343;VS-5584;VS-5584, >=98%;VS-5584 VS5584;VS-5584 USP/EP/BP;VS-5584 (SB2343);VS-5584;VS5584;VS 5584

CBNumber:: CB42666411

Molecular Formula:: C17H22N8O

Molecular Weight:: 354.41

MDL Number:: MFCD25372027

MOL File:: 1246560-33-7.mol

MSDS File:: SDS

Last updated:2023-05-21 10:59:17

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VS-5584 Properties

Boiling point	687.2±65.0 °C(Predicted)
Density	1.48±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	insoluble in H2O; ≥17.7 mg/mL in DMSO; ≥4.71 mg/mL in EtOH with ultrasonic
form	solid
pka	4.53±0.10(Predicted)
FDA UNII	W71J4X250V

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07,GHS08,GHS09
Signal word	Danger
Hazard statements	H302-H410-H372
Precautionary statements	P260-P264-P273-P501

VS-5584 price More Price(20)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	16294	VS-5584 ≥98%	1246560-33-7	1mg	$32	2024-03-01	Buy
Cayman Chemical	16294	VS-5584 ≥98%	1246560-33-7	5mg	$139	2024-03-01	Buy
Cayman Chemical	16294	VS-5584 ≥98%	1246560-33-7	10mg	$230	2024-03-01	Buy
ChemScene	CS-1202	VS-5584 98.15%	1246560-33-7	5mg	$90	2021-12-16	Buy
AK Scientific	2797AH	5-(9-Isopropyl-8-methyl-2-morpholino-9H-purin-6-yl)pyrimidin-2-amine	1246560-33-7	10mg	$353	2021-12-16	Buy

Product number	Packaging	Price	Buy
16294	1mg	$32	Buy
16294	5mg	$139	Buy
16294	10mg	$230	Buy
CS-1202	5mg	$90	Buy
2797AH	10mg	$353	Buy

VS-5584 Chemical Properties,Uses,Production

Description

Phosphatidylinositol 3-kinase (PI3K) signaling through Akt/PKB and the mammalian target of rapamycin (mTOR) controls gene expression related to cell proliferation, differentiation, and apoptosis. Increased activity of this pathway is important in many types of cancer. VS-5584 is a purine analog that inhibits mTOR (IC₅₀ = 37 nM) and PI3K (IC₅₀s = 16, 68, 25, and 42 nM for the α, β, γ, and δ isoforms, respectively) without relevant activity against more than 400 additional lipid and protein kinases. By inhibiting the phosphorylation of substrates downstream of PI3K and mTOR, VS-5584 demonstrates broad anti-proliferative sensitivity leading to tumor growth inhibition in human tumor models.

target

mTOR

VS-5584 synthesis

Synthesis of VS-5584 from Ethanamine, N-[(3,5-dichlorophenyl)methylene]-2,2-diethoxy- and DIMETHYLZINC

VS-5584 Preparation Products And Raw materials

Raw materials

DIMETHYLZINC

Preparation Products

VS-5584 Suppliers

Global( 95)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22968	58
Chongqing Chemdad Co., Ltd	+86-023-61398051 +8613650506873	sales@chemdad.com	China	39916	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	29474	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10523	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
TargetMol Chemicals Inc.	+1-781-999-5354	support@targetmol.com	United States	19973	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	13417589054	trendseenbio@gmail.com	China	11681	58
LEAPCHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	43348	58

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Hubei xin bonus chemical co. LTD	58
Chongqing Chemdad Co., Ltd	58
Dideu Industries Group Limited	58
Zhejiang J&C Biological Technology Co.,Limited	58
InvivoChem	58
TargetMol Chemicals Inc.	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	58
LEAPCHEM CO., LTD.	58

View Lastest Price from VS-5584 manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2019-07-06	VS-5584 1246560-33-7	US $2.00 / kg	1kg	99%	100kg	Career Henan Chemical Co

VS-5584
1246560-33-7
US $2.00 / kg
99%
Career Henan Chemical Co

VS-5584 Spectrum

VS-5584(1246560-33-7)¹HNMR

1246560-33-7(VS-5584)Related Search:

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XL147

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2-Pyrimidinamine, 5-[8-methyl-9-(1-methylethyl)-2-(4-morpholinyl)-9H-purin-6-yl]- 5-[8-Methyl-9-(1-methylethyl)-2-(4-morpholinyl)-9H-purin-6-yl]-2-pyrimidinamine VS-5584 VS-5584, >=98% VS-5584 SB 2343 SB2343 5-(9-Isopropyl-8-Methyl-2-Morpholin-4-yl-9H-purin-6-yl)-pyriMidin-2-ylaMine 5-(9-ISOPROPYL-8-METHYL-2-MORPHOLINO-9H-PURIN-6-YL)PYRIMIDIN-2-AMINE 5-[8-Methyl-9-(1-methylethyl)-2-(4-morpholinyl)-9H-purin-6-yl]-2-pyrimidinamine VS-5584 (SB2343);VS-5584;VS5584;VS 5584 SB-2343; VS5584; VS 5584; SB2343; SB 2343 CS-875 5-[9-Isopropyl-8-methyl-2-(morpholin-4-yl)purin-6-yl]pyrimidin-2-amine VS-5584 USP/EP/BP SB-2343 VS-5584 (SB2343) VS-5584 VS5584 1246560-33-7 C17H22N8O Akt mTOR PI3K PI3K/Akt/mTOR Inhibitors