RK-20449 trihydrochloride
- CAS No.
- 1435934-25-0
- Chemical Name:
- RK-20449 trihydrochloride
- Synonyms
- A 419259 3HCl;A-419259 (hydrochloride);RK20449 trihydrochloride;RK-20449 trihydrochloride;RK 20449 trihydrochloride;A419259; A-419259 TRIHYDROCHLORIDE;RK 20449 trihydrochloride,A 419259 trihydrochloride,Src,Inhibitor,inhibit;7-((1r,4r)-4-(4-methylpiperazin-1-yl)cyclohexyl)-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine trihydrochloride;7-[trans-4-(4-Methyl-1-piperazinyl)cyclohexyl]-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine hydrochloride (1:3);A419259 TRIHYDROCHLORIDE;A-419259 TRIHYDROCHLORIDE;RK 20449 TRIHYDROCHLORIDE;RK20449 TRIHYDROCHLORIDE;RK-20449 TRIHYDROCHLORIDE
- CBNumber:
- CB42667463
- Molecular Formula:
- C29H35ClN6O
- Molecular Weight:
- 519.09
- MDL Number:
- MOL File:
- 1435934-25-0.mol
RK-20449 trihydrochloride price More Price(16)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 18168 | A-419259 (hydrochloride) ≥95% | 1435934-25-0 | 1mg | $44 | 2024-03-01 | Buy |
| Cayman Chemical | 18168 | A-419259 (hydrochloride) ≥95% | 1435934-25-0 | 5mg | $161 | 2024-03-01 | Buy |
| Cayman Chemical | 18168 | A-419259 (hydrochloride) ≥95% | 1435934-25-0 | 10mg | $299 | 2024-03-01 | Buy |
| Cayman Chemical | 18168 | A-419259 (hydrochloride) ≥95% | 1435934-25-0 | 25mg | $692 | 2024-03-01 | Buy |
| TRC | A101040 | A-419259 trihydrochloride | 1435934-25-0 | 50mg | $1105 | 2021-12-16 | Buy |
RK-20449 trihydrochloride Chemical Properties,Uses,Production
Uses
A 419259 Trihydrochloride is the hydrochloride form of A 419259 which is a Src kinase inhibitor and can be used in treatment of chronic myelogenous leukemia, lymphangioleiomyomatosis and tuberous sclerosis.
Biological Activity
a 419259 trihydrochloride is an orally available inhibitor of lck with ic50 value of 15 nm [1].lck is a src family tyrosine kinase. inhibition of this enzyme results in a prevention of t-cell activation and provides an application for treating t-cell dependent processes such as autoimmune and inflammatory diseases. a 419259 trihydrochloride is screened out by its potent inhibitory activity against the recombinant lck (64–509) with ic50 value of 15nm. it is also a selective inhibitor. it shows inactive against a panel of other kinases including cmet, igfr, pkc and pdgfr. besides that, a 419259 trihydrochloride is found to inhibit the production of il-2 with ic50 value of 25nm in jurkat cells. moreover, administration of a 419259 trihydrochloride reduces il-2 production in mice with ed50 value of 2.5 mg/kg. a 419259 trihydrochloride also has efficacy of the antigen specific t-cell immune response. administration of this compound inhibits ifn-γ production during the in vivo priming phase [1].
storage
Desiccate at RT
References
[1] calderwood d j, johnston d n, munschauer r, et al. pyrrolo [2, 3-d] pyrimidines containing diverse n-7 substituents as potent inhibitors of lck. bioorganic & medicinal chemistry letters, 2002, 12(12): 1683-1686.
RK-20449 trihydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49739 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
| Chemwill Asia Co.,Ltd. | 86-21-51086038 | chemwill_asia@126.com | CHINA | 23931 | 58 |
| ChemCell Biomedicine Co.,Ltd. | 020-13556033878 2965585218 13556033878 | chemcell@hotmail.com | China | 369 | 52 |
| Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 7553 | 61 |
View Lastest Price from RK-20449 trihydrochloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-07-06 | RK-20449 trihydrochloride
1435934-25-0
|
US $1.00 / KG | 1KG | 99% | 20kg | Career Henan Chemical Co |
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- RK-20449 trihydrochloride
1435934-25-0
- US $1.00 / KG
- 99%
- Career Henan Chemical Co