Encorafenib (LGX818)
- CAS No.
- 1269440-17-6
- Chemical Name:
- Encorafenib (LGX818)
- Synonyms
- Encorafenib;LGX818;LGX-818;LGX 818;CS-1037;NSC4820;NSC 4820;NSC-4820;LGX818, >=98%;LGX818, Encorafenib
- CBNumber:
- CB42668617
- Molecular Formula:
- C22H27ClFN7O4S
- Molecular Weight:
- 540.01
- MDL Number:
- MFCD25976758
- MOL File:
- 1269440-17-6.mol
| Melting point | 184-185°C |
|---|---|
| Density | 1.45±0.1 g/cm3(Predicted) |
| storage temp. | -20°C Freezer, Under inert atmosphere |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| pka | 5.94±0.10(Predicted) |
| form | Solid |
| color | White to Off-White |
| NCI Dictionary of Cancer Terms | encorafenib |
| FDA UNII | 8L7891MRB6 |
| NCI Drug Dictionary | encorafenib |
| ATC code | L01EC03 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P305+P351+P338 | |||||||||
| NFPA 704 |
|
Encorafenib (LGX818) price More Price(27)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 16994 | Encorafenib ≥98% | 1269440-17-6 | 500μg | $37 | 2024-03-01 | Buy |
| Cayman Chemical | 16994 | Encorafenib ≥98% | 1269440-17-6 | 1mg | $70 | 2024-03-01 | Buy |
| Cayman Chemical | 16994 | Encorafenib ≥98% | 1269440-17-6 | 5mg | $163 | 2024-03-01 | Buy |
| TRC | L397655 | LGX818 | 1269440-17-6 | 0.5mg | $90 | 2021-12-16 | Buy |
| Usbiological | 453725 | LGX 818 | 1269440-17-6 | 500ug | $368 | 2021-12-16 | Buy |
Encorafenib (LGX818) Chemical Properties,Uses,Production
Description
Encorafenib (LGX818) is a new-generation BRAF inhibitor that is under evaluation in clinical trials. However, the underlying mechanism remains to be elucidated. Here we show that LGX818 potently decreased ERK phosphorylation and inhibited proliferation in BRAFV600E melanoma cell lines. Moreover, LGX818 downregulated CyclinD1 in a glycogen synthase kinase 3β-independent manner and induced cell cycle arrest in the G1 phase.
Uses
LGX 818 is potent and selective BRAFV600E kinase inhibitor and can be used for the treatment of proliferative diseases such as solid tumor diseases.
Biological Activity
Encorafenib (LGX818) is a highly potent RAF inhibitor with selective anti-proliferative and apoptotic activity in cells expressing B-RAF(V600E) with EC50 of 4 nM. Phase 3.
Clinical Use
Encorafenib (LGX818) is a new-generation BRAF inhibitor. It is currently under investigation in clinical trials for the treatment of BRAF mutant metastatic melanoma patients . LGX818 induces sustained mitogen-activated protein kinase (MAPK) pathway inhibition and has selective anti-proliferative and apoptotic activity in cells expressing BRAFV600E. However, the mechanism by which LGX818 suppresses BRAF mutant melanoma cell proliferation has not been thoroughly investigated.
target
B-RAF(V600E)
References
[1] stuart d d, li n, poon d j, et al. preclinical profile of lgx818: a potent and selective raf kinase inhibitor. cancer research, 2012, 72(8 supplement): 3790.
[2] huang t, karsy m, zhuge j, et al. b-raf and the inhibitors: from bench to bedside. j hematol oncol, 2013, 6(1): 30.
Encorafenib (LGX818) Preparation Products And Raw materials
Encorafenib (LGX818) Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Rochi Pharmaceutical Co.,Ltd. | 21-38751876 +8615000076078 | info@rochipharma.com | China | 431 | 58 |
| Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 | figo.gao@foxmail.com | China | 6992 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 29220 | 58 |
| Baoji Guokang Bio-Technology Co., Ltd. | 0917-3909592 13892490616 | gksales1@gk-bio.com | China | 9339 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
| Hangzhou Proserre Chemical Co.,Ltd. | +86-571-86088112 | info@proserre.com | China | 1077 | 58 |
Related articles
- A BRAF inhibitor: Encorafenib (LGX818)
- Encorafenib (LGX818) is a BRAF inhibitor, and detection of a BRAF V600E or BRAF V600K mutation in tumor specimens is required ....
- Dec 27，2023
View Lastest Price from Encorafenib (LGX818) manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2021-07-13 | Encorafenib (LGX818)
1269440-17-6
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd | |
 |
2021-07-10 | Encorafenib (LGX818)
1269440-17-6
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd | |
 |
2019-12-26 | Encorafenib (LGX818)
1269440-17-6
|
US $6.60 / KG | 1KG | 97%-99% | 1kg-1000kg | Career Henan Chemical Co |
-
- Encorafenib (LGX818)
1269440-17-6
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- Encorafenib (LGX818)
1269440-17-6
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- Encorafenib (LGX818)
1269440-17-6
- US $6.60 / KG
- 97%-99%
- Career Henan Chemical Co