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Ozanimod

Ozanimod
Ozanimod structure
CAS No.
1306760-87-1
Chemical Name:
Ozanimod
Synonyms
RPC1063;Ozanimod;RPC1063 Ozanimod;oxanimod(RPC1063);Ozanimod (RPC1063);(S)-5-(3-(1-((2-hydroxyethyl)amino)-2,3-dihydro-1H-inden-4-yl)-1,2,4-oxadiazol-5-yl)-2-isopropoxybenzonitrile;5-[3-[(1S)-2,3-Dihydro-1-[(2-hydroxyethyl)amino]-1H-inden-4-yl]-1,2,4-oxadiazol-5-yl]-2-(1-methylethoxy)benzonitrile;Benzonitrile, 5-[3-[(1S)-2,3-dihydro-1-[(2-hydroxyethyl)amino]-1H-inden-4-yl]-1,2,4-oxadiazol-5-yl]-2-(1-methylethoxy)-;Benzonitrile, 5-[3-[(1S)-2,3-dihydro-1-[(2-hydroxyethyl)aMino]-1H-inden-4-yl]-1,2,4-oxadiazol-5-yl]-2-(1-Methylethoxy)- (free base)
CBNumber:
CB42716147
Molecular Formula:
C23H24N4O3
Formula Weight:
404.46166
MOL File:
1306760-87-1.mol

Ozanimod Properties

SAFETY

Ozanimod price More Price(4)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 19922 Ozanimod ≥98% 1306760-87-1 1mg $35 2018-11-19 Buy
Cayman Chemical 19922 Ozanimod ≥98% 1306760-87-1 5mg $158 2018-11-19 Buy
Cayman Chemical 19922 Ozanimod ≥98% 1306760-87-1 10mg $280 2018-11-19 Buy
Cayman Chemical 19922 Ozanimod ≥98% 1306760-87-1 25mg $656 2018-11-19 Buy

Ozanimod Chemical Properties,Uses,Production

Enzyme inhibitor

This orally available S1PR1 modulator (FW = 404.46 g/mol; CAS 1306760- 87-1; Solubility: 81 mg/mL DMSO; < 1 mg/mL H2O), also named RPC1063 and 5-[3-[ (1S) -2,3-dihydro-1-[ (2-hydroxyethyl) amino]-1H-inden- 4-yl]-1,2,4-oxadiazol-5-yl]-2- (1-methylethoxy) benzonitrile, selectively targets sphingosine 1-Phosphate (S1P) receptors, which mediate multiple processes, including lymphocyte trafficking, cardiac function, and endothelial barrier integrity. Ozanimod is specific for S1P1R (IC50 = 0.4 nM) and S1P5R, inducing S1P1R internalization and reversibly reducing the number of circulating B and CCR7+ T lymphocytes in vivo. It shows high oral bioavailability and volume of distribution, and a circulatory half-life that supports once daily dosing. Oral ozanimod reduced inflammation and disease parameters in three autoimmune disease models, commending its use in the treatment of relapsing multiple sclerosis (RMS) and inflam- matory bowel disease (IBD). Indeed, the safety and efficacy of this modulator ozanimod in relapsing multiple sclerosis is indicated on the basis of a randomized, placebo-controlled, Phase 2 trial. Other SIPR1-directed immunomodulators include laquinimod, ponesimod, and siponimod.

Ozanimod Preparation Products And Raw materials

Raw materials

Preparation Products


Ozanimod Suppliers

Global( 71)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21930 58
Beijing Cooperate Pharmaceutical Co.,Ltd.
+86-10-60279497 +86(0)15646567669
+86-10-60279497 sales01@cooperate-pharm.com CHINA 1530 55
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20680 55
Nanjing ChemLin Chemical Industry Co., Ltd.
025-83697070;product@chemlin.com.cn
product@chemlin.com.cn CHINA 3015 60
ATK CHEMICAL COMPANY LIMITED
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 ivan@atkchemical.com CHINA 24196 60
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 20516 58
Nanjing Dolon Biotechnology Co.,Ltd.
18905173768
sales@dolonchem.com CHINA 2972 58
ShangHai Caerulum Pharma Discovery Co., Ltd. 021-64556180
021-69018966*808 sales-cpd@caerulumpharma.com China 507 58
Shanghai Biopharmaleader Co., Ltd. +86 18721201413
+86 (21) 5775-8967 sales@biopharmaleader.com China 1721 58
Nanjing YakeLun Pharmaceutical Co., Ltd. 025-85986826
025-85986826 sales@accoron.com China 3846 55

View Lastest Price from Ozanimod manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-12-24 Benzonitrile, 5-[3-[(1S)-2,3-dihydro-1-[(2-hydroxyethyl)aMino]-1H-inden-4-yl]-1,2,4-oxadiazol-5-yl]-2-(1-Methylethoxy)- (free base)
1306760-87-1
US $2.00 / kg 1kg 99% 100kg career henan chemical co

1306760-87-1(Ozanimod)Related Search:


  • Benzonitrile, 5-[3-[(1S)-2,3-dihydro-1-[(2-hydroxyethyl)aMino]-1H-inden-4-yl]-1,2,4-oxadiazol-5-yl]-2-(1-Methylethoxy)- (free base)
  • Ozanimod (RPC1063)
  • Ozanimod
  • RPC1063
  • -
  • 13067-87-1
  • RPC1063 Ozanimod
  • 1306760-87-1
  • Benzonitrile, 5-[3-[(1S)-2,3-dihydro-1-[(2-hydroxyethyl)amino]-1H-inden-4-yl]-1,2,4-oxadiazol-5-yl]-2-(1-methylethoxy)-
  • 5-[3-[(1S)-2,3-Dihydro-1-[(2-hydroxyethyl)amino]-1H-inden-4-yl]-1,2,4-oxadiazol-5-yl]-2-(1-methylethoxy)benzonitrile
  • (S)-5-(3-(1-((2-hydroxyethyl)amino)-2,3-dihydro-1H-inden-4-yl)-1,2,4-oxadiazol-5-yl)-2-isopropoxybenzonitrile
  • oxanimod(RPC1063)
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