OLIGOMYCIN A
- CAS No.
- 579-13-5
- Chemical Name:
- OLIGOMYCIN A
- Synonyms
- OLIGOMYCIN COMPLEX;CS-1898;Oli;MCH 32;mycin A;AOligoMyci;OLIGOMYCIN A;Oligomycin A, >=98%;Oligomycin A MCH 32;OLIGOMYCIN A USP/EP/BP
- CBNumber:
- CB4274065
- Molecular Formula:
- C45H74O11
- Molecular Weight:
- 791.06
- MDL Number:
- MFCD00065705
- MOL File:
- 579-13-5.mol
- MSDS File:
- SDS
| Melting point | 150-151℃ |
|---|---|
| Boiling point | 886.3±65.0 °C(Predicted) |
| Density | 1.14 |
| storage temp. | Sealed in dry,Store in freezer, under -20°C |
| solubility | Soluble in DMSO, ethanol or acetone |
| pka | 12.52±0.70(Predicted) |
| form | powder |
| color | white to off-white |
| Merck | 13,6902 |
| BRN | 5702132 |
| InChIKey | MNULEGDCPYONBU-WMBHJXFZSA-N |
| EWG's Food Scores | 1 |
| FDA UNII | 05HQS4AI99 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P264-P270-P301+P312a-P330-P501a | |||||||||
| Hazard Codes | Xn,T | |||||||||
| Risk Statements | 22-68/20/21/22-20/21/22 | |||||||||
| Safety Statements | 36/37-24/25 | |||||||||
| RIDADR | 2811 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | RK3325000 | |||||||||
| F | 3-10 | |||||||||
| HazardClass | 6.1(b) | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29419090 | |||||||||
| NFPA 704 |
|
OLIGOMYCIN A price More Price(23)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 75351 | Oligomycin A ≥95% (HPLC) | 579-13-5 | 5mg | $198 | 2024-03-01 | Buy |
| Cayman Chemical | 11342 | Oligomycin A ≥95% | 579-13-5 | 1mg | $56 | 2024-03-01 | Buy |
| Cayman Chemical | 11342 | Oligomycin A ≥95% | 579-13-5 | 5mg | $135 | 2024-03-01 | Buy |
| Cayman Chemical | 11342 | Oligomycin A ≥95% | 579-13-5 | 10mg | $241 | 2024-03-01 | Buy |
| Cayman Chemical | 11342 | Oligomycin A ≥95% | 579-13-5 | 25mg | $362 | 2024-03-01 | Buy |
OLIGOMYCIN A Chemical Properties,Uses,Production
Description
Oligomycins are macrolides created by Streptomyces species that can be toxic to other organisms. Different oligomycin isomers are highly specific for the disruption of mitochondrial metabolism. Oligomycin A, a dominant analog of the isomers, is an inhibitor of mitochondrial F1FO ATP synthase that induces apoptosis in a variety of cell types (average GI50 = 270 nM). Oligomycin A exhibits antifungal, antitumor, and nematocidal activities, but has poor solubility in water and other biocompatible solvents, which limits its clinical application.
Chemical Properties
White powder
Uses
Oligomycin A is the dominant analogue of a class of macrocyclic lactones isolated from selected strains of Streptomyces sp.. Oligomycin A is an inhibitor of mitochondrial F1F0-ATPase. It induces apoptosis in a variety of cell types, makes cells more susceptible to cell death, and also leads to a switch in the death mode from apoptosis to necrosis. Oligomycin A exhibits a broad biological profile including antifungal, antitumor and nematocidal activities.
Uses
Oligomycin A is the dominant analogue of a class macrocyclic lactones isolated from selected strains of Streptomyces sp.. Oligomycin A is an inhibitor of mitochondrial F1F0-ATPase. It induces apoptosis in a variety of cell types, makes cells more susceptible to cell death, and also leads to a switch in the death mode from apoptosis to necrosis. Oligomycin A exhibits a broad biological profile including antifungal, antitumour and nematocidal activities.
Uses
Oligomycin A is a macrolide with fungicidal activity isolated from Streptomyces species.
storage
-20°C
References
[1]. jastroch m, divakaruni as, mookerjee s, et al. mitochondrial proton and electron leaks. essays biochemistry, 2010, 47:53-67.
[2]. shchepina la, pletjushkina oy, avetisyan av, et al. oligomycin, inhibitor of the f-0 part of h+-atp-synthase, suppresses the tnf-induced apoptosis. oncogene, 2002, 53: 8149-8157.
[3]. salomon ar, voehringer dw, herzenberg la, et al. understanding and exploiting the mechanistic basis for selectivity of polyketide inhibitors of f0f1-atpase. proceedings of the national academy of sciences of the united states of america, 2000, 97(26): 14766-14771.
[4]. alexander r, adina v, ivan b, et al. overcoming intrinsic multi-drug resistance in melanoma by blocking the mitochondrial respiratory chain of slow-cycling jarid1bhigh cells. cancer cell, 2013, 23(6): 811-825.
OLIGOMYCIN A Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-81138252 +86-18789408387 | 1057@dideu.com | China | 3684 | 58 |
| Fuxin Pharmaceutical | +86-021-021-50872116 +8613122107989 | contact@fuxinpharm.com | China | 10297 | 58 |
| Hubei Ipure Biology Co., Ltd | +8613367258412 | ada@ipurechemical.com | China | 10326 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 | 1026@dideu.com | China | 9456 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 29321 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
| Henan Alfa Chemical Co., Ltd | +8618339805032 | alfa4@alfachem.cn | China | 12755 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
View Lastest Price from OLIGOMYCIN A manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2021-06-24 | OLIGOMYCIN A USP/EP/BP
579-13-5
|
US $1.10 / g | 1g | 99.9% | 100 Tons Min | Dideu Industries Group Limited | |
 |
2020-05-10 | OligoMycin A
579-13-5
|
US $1.00 / KG | 1KG | 99% | 20T | Shaanxi Dideu Medichem Co. Ltd | |
 |
2019-12-23 | OLIGOMYCIN A
579-13-5
|
US $1.00 / g | 100g | 99% | G/KG/T | Career Henan Chemical Co |
-
- OLIGOMYCIN A USP/EP/BP
579-13-5
- US $1.10 / g
- 99.9%
- Dideu Industries Group Limited
-
- OligoMycin A
579-13-5
- US $1.00 / KG
- 99%
- Shaanxi Dideu Medichem Co. Ltd
-
- OLIGOMYCIN A
579-13-5
- US $1.00 / g
- 99%
- Career Henan Chemical Co
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