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(S)-1-(3-methyl-2-oxobutyl)-8-((R)-3-methylmorpholino)-2-(trifluoromethyl)-3,4-dihydro-1H-pyrimido[1,2-a]pyrimidin-6(2H)-one

(S)-1-(3-methyl-2-oxobutyl)-8-((R)-3-methylmorpholino)-2-(trifluoromethyl)-3,4-dihydro-1H-pyrimido[1,2-a]pyrimidin-6(2H)-one Structure
(S)-1-(3-methyl-2-oxobutyl)-8-((R)-3-methylmorpholino)-2-(trifluoromethyl)-3,4-dihydro-1H-pyrimido[1,2-a]pyrimidin-6(2H)-one structure
CAS No.
1523404-29-6
Chemical Name:
(S)-1-(3-methyl-2-oxobutyl)-8-((R)-3-methylmorpholino)-2-(trifluoromethyl)-3,4-dihydro-1H-pyrimido[1,2-a]pyrimidin-6(2H)-one
Synonyms
129208;Vps34-IN-2;Vps34 inhibitor 2;Vps-34-IN-2,Vps34 IN 2,Vps34IN2;(S)-1-(3-Methyl-2-oxobutyl)-8-((R)-3-methylmorpholino)-2-(trifluoromethyl)-3,4-dihydro-1H-pyri;(S)-1-(3-methyl-2-oxobutyl)-8-((R)-3-methylmorpholino)-2-(trifluoromethyl)-3,4-dihydro-1H-pyrimido[1,2-a]pyrimidin-6(2H)-one;(S)-9-(3-Methyl-2-oxobutyl)-2-((R)-3-methylmorpholino)-8-(trifluoromethyl)-6,7,8,9-tetrahydro-4H-pyrimido[1,2-a]pyrimidin-4-one;(8S)-6,7,8,9-Tetrahydro-2-[(3R)-3-methyl-4-morpholinyl]-9-(3-methyl-2-oxobutyl)-8-(trifluoromethyl)-4H-pyrimido[1,2-a]pyrimidin-4-one;4H-Pyrimido[1,2-a]pyrimidin-4-one, 6,7,8,9-tetrahydro-2-[(3R)-3-methyl-4-morpholinyl]-9-(3-methyl-2-oxobutyl)-8-(trifluoromethyl)-, (8S)-
CBNumber:
CB42742380
Molecular Formula:
C18H25F3N4O3
Molecular Weight:
402.41
MDL Number:
MFCD28411355
MOL File:
1523404-29-6.mol
Last updated:2023-05-18 11:31:20
Request For Quotation

(S)-1-(3-methyl-2-oxobutyl)-8-((R)-3-methylmorpholino)-2-(trifluoromethyl)-3,4-dihydro-1H-pyrimido[1,2-a]pyrimidin-6(2H)-one Properties

Boiling point 466.4±55.0 °C(Predicted)
Density 1.40±0.1 g/cm3(Predicted)
storage temp. Sealed in dry,Room Temperature
solubility Ethanol: 50 mg/mL (124.25 mM)
pka 0.08±0.40(Predicted)

(S)-1-(3-methyl-2-oxobutyl)-8-((R)-3-methylmorpholino)-2-(trifluoromethyl)-3,4-dihydro-1H-pyrimido[1,2-a]pyrimidin-6(2H)-one price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC T294805 (8S)-6,7,8,9-Tetrahydro-2-[(3R)-3-methyl-4-morpholinyl]-9-(3-methyl-2-oxobutyl)-8-(trifluoromethyl)-4H-pyrimido[1,2-a]pyrimidin-4-one 1523404-29-6 1mg $705 2021-12-16 Buy
ChemScene CS-8063 Vps34-IN-2 99.63% 1523404-29-6 5mg $708 2021-12-16 Buy
ChemScene CS-8063 Vps34-IN-2 99.63% 1523404-29-6 10mg $1068 2021-12-16 Buy
ChemScene CS-8063 Vps34-IN-2 99.63% 1523404-29-6 25mg $2280 2021-12-16 Buy
ChemScene CS-8063 Vps34-IN-2 99.63% 1523404-29-6 50mg $4080 2021-12-16 Buy
Product number Packaging Price Buy
T294805 1mg $705 Buy
CS-8063 5mg $708 Buy
CS-8063 10mg $1068 Buy
CS-8063 25mg $2280 Buy
CS-8063 50mg $4080 Buy

(S)-1-(3-methyl-2-oxobutyl)-8-((R)-3-methylmorpholino)-2-(trifluoromethyl)-3,4-dihydro-1H-pyrimido[1,2-a]pyrimidin-6(2H)-one Chemical Properties,Uses,Production

Uses

(8S)-6,7,8,9-Tetrahydro-2-[(3R)-3-methyl-4-morpholinyl]-9-(3-methyl-2-oxobutyl)-8-(trifluoromethyl)-4H-pyrimido[1,2-a]pyrimidin-4-one, is a novel, potent and selective inhibitor of Vps34 with IC50s of 2 and 82 nM on the Vps34 enzymatic assay and the GFP-FYVE cellular assay, respectively.

(S)-1-(3-methyl-2-oxobutyl)-8-((R)-3-methylmorpholino)-2-(trifluoromethyl)-3,4-dihydro-1H-pyrimido[1,2-a]pyrimidin-6(2H)-one synthesis

16075-42-6
1523404-29-6
Synthesis of (S)-1-(3-methyl-2-oxobutyl)-8-((R)-3-methylmorpholino)-2-(trifluoromethyl)-3,4-dihydro-1H-pyrimido[1,2-a]pyrimidin-6(2H)-one from 2-Amino-4-(trifluoromethyl)pyrimidine

(S)-1-(3-methyl-2-oxobutyl)-8-((R)-3-methylmorpholino)-2-(trifluoromethyl)-3,4-dihydro-1H-pyrimido[1,2-a]pyrimidin-6(2H)-one Preparation Products And Raw materials

Raw materials

(S)-8-chloro-2-(trifluoromethyl)-3,4-dihydro-1H-pyrimido[1,2-a]pyrimidin-6(2H)-one 2-Amino-4-(trifluoromethyl)pyrimidine (S)-8-((R)-3-methylmorpholino)-2-(trifluoromethyl)-3,4-dihydro-1H-pyrimido[1,2-a]pyrimidin-6(2H)-one 1-Bromo-3-methyl-2-butanone

Preparation Products

(S)-1-(3-methyl-2-oxobutyl)-8-((R)-3-methylmorpholino)-2-(trifluoromethyl)-3,4-dihydro-1H-pyrimido[1,2-a]pyrimidin-6(2H)-one Suppliers

Global( 12)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 19892 58
ChemShuttle, Inc. 0510-83588313-802 18800520310; sales@chemshuttle.com China 3009 62
Sichuan Wei Keqi Biological Technology Co., Ltd. 028-81700200 18116577057 3003855609@qq.com China 7892 56
Taizhou Crene Biotechnology Co. Ltd. 0576-88813233 13396860566 sales@pharm-intermediates.com China 2013 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11289 58
Shanghai hongqu biomedical technology co. LTD 88888888888 hongquchem@qq.com China 5132 58
Changzhou Furuisi Biotechnology Co., Ltd 0519-85524369 3477467573@qq.com China 8618 58
Bide Pharmatech Ltd. 400-1647117 15221909166 product02@bidepharm.com China 61720 58
TargetMol Chemicals Inc. 4008200310 marketing@tsbiochem.com China 24131 58
Supplier Advantage
TargetMol Chemicals Inc. 		58
ChemShuttle, Inc. 62
Sichuan Wei Keqi Biological Technology Co., Ltd. 56
Taizhou Crene Biotechnology Co. Ltd. 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 58
Shanghai hongqu biomedical technology co. LTD 58
Changzhou Furuisi Biotechnology Co., Ltd 58
Bide Pharmatech Ltd. 58
TargetMol Chemicals Inc. 58
(S)-1-(3-methyl-2-oxobutyl)-8-((R)-3-methylmorpholino)-2-(trifluoromethyl)-3,4-dihydro-1H-pyrimido[1,2-a]pyrimidin-6(2H)-one (S)-1-(3-Methyl-2-oxobutyl)-8-((R)-3-methylmorpholino)-2-(trifluoromethyl)-3,4-dihydro-1H-pyri (8S)-6,7,8,9-Tetrahydro-2-[(3R)-3-methyl-4-morpholinyl]-9-(3-methyl-2-oxobutyl)-8-(trifluoromethyl)-4H-pyrimido[1,2-a]pyrimidin-4-one 4H-Pyrimido[1,2-a]pyrimidin-4-one, 6,7,8,9-tetrahydro-2-[(3R)-3-methyl-4-morpholinyl]-9-(3-methyl-2-oxobutyl)-8-(trifluoromethyl)-, (8S)- Vps34 inhibitor 2 129208 Vps34-IN-2 Vps-34-IN-2,Vps34 IN 2,Vps34IN2 (S)-9-(3-Methyl-2-oxobutyl)-2-((R)-3-methylmorpholino)-8-(trifluoromethyl)-6,7,8,9-tetrahydro-4H-pyrimido[1,2-a]pyrimidin-4-one 1523404-29-6 C18H25F3N4O3 API