Isavuconazonium sulfate
- CAS No.
- 946075-13-4
- Chemical Name:
- Isavuconazonium sulfate
- Synonyms
- Isavuconazon;ISAVUCONAZOLE SULFATE;BAL 8557-002;Edoxaban Free Base;Isaaconazole sulfate;Escaconazole sulfate;savuconazonium Sulfate;lsavuconazonium sulfate;Isavuconazonium sulfate;Isavuconaconiun sulfate
- CBNumber:
- CB42748579
- Molecular Formula:
- C35H36F2N8O9S2
- Molecular Weight:
- 814.84
- MDL Number:
- MFCD27987905
- MOL File:
- 946075-13-4.mol
- MSDS File:
- SDS
| storage temp. | Store at -20°C |
|---|---|
| solubility |
DMSO:93.34(Max Conc. mg/mL);114.55(Max Conc. mM) DMSO:PBS (pH 7.2) (1:5):0.16(Max Conc. mg/mL);0.2(Max Conc. mM) Ethanol:10.0(Max Conc. mg/mL);12.27(Max Conc. mM) |
| form | A crystalline solid |
| color | White to off-white |
| InChIKey | LWXUIUUOMSMZKJ-XHOYWDQFNA-M |
| SMILES | S(O)([O-])(=O)=O.[C@@](C1C=C(F)C=CC=1F)(O)(CN1N=C[N+](C(C)OC(=O)N(C2N=CC=CC=2COC(=O)CNC)C)=C1)[C@H](C1SC=C(C2C=CC(C#N)=CC=2)N=1)C |&1:5,41,r| |
| FDA UNII | 31Q44514JV |
| UNSPSC Code | 51111800 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS07,GHS08,GHS09 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H302-H361d-H372-H410 | |||||||||
| Precautionary statements | P202-P260-P264-P273-P301+P312-P308+P313 | |||||||||
| NFPA 704 |
|
Isavuconazonium sulfate price More Price(15)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML3188 | Isavuconazonium sulfate ≥95% (HPLC) | 946075-13-4 | 5MG | $89 | 2024-03-01 | Buy |
| Sigma-Aldrich | SML3188 | Isavuconazonium sulfate ≥95% (HPLC) | 946075-13-4 | 25MG | $359 | 2024-03-01 | Buy |
| Cayman Chemical | 23950 | Isavuconazonium (sulfate) ≥95% | 946075-13-4 | 500μg | $62 | 2024-03-01 | Buy |
| Cayman Chemical | 23950 | Isavuconazonium (sulfate) ≥95% | 946075-13-4 | 1mg | $115 | 2024-03-01 | Buy |
| Cayman Chemical | 23950 | Isavuconazonium (sulfate) ≥95% | 946075-13-4 | 5mg | $477 | 2024-03-01 | Buy |
Isavuconazonium sulfate Chemical Properties,Uses,Production
Description
Isavuconazonium sulfate is an orally bioavailable, safe, second-generation triazole antifungal agent approved by the U.S. Food and Drug Administration (FDA) for the treatment of invasive Aspergillosis and invasive Mucormycosis in adults 18 years of age and older. Currently available under the brand name Cresemba, the most common side effects include liver test abnormalities, nausea, vomiting, dyspnea, abdominal pain, diarrhoea, injection site reactions, headache, hypokalemia and rash.
Uses
Isavuconazonium Sulfate can be prepared to be used as an antifungal drug.
Definition
ChEBI: An azaheterocycle sulfate salt that is a prodrug for isavuconazole, an antifungal agent used for the treatment of invasive aspergillosis and invasive mucormycosis.
in vivo
Isavuconazonium sulfate (215 mg/kg; p.o.; Three times a day for 4 days) has anti-R.delemar virus activity in ICR mice infected with mucormycosis[4].
| Animal Model: | Neutropenic male ICR mouse model of intratracheal infection[4] |
| Dosage: | 215 mg/kg |
| Administration: | Oral gavage (p.o.); Three times a day for 4 days. |
| Result: | Increased the survival rate of neutropenic mice infected with R. delemar. Reduced fungal load in the lungs and brains of mice. |
Metabolism
Isavuconazonium sulfate (Cresemba) is the water-soluble prodrug of isavuconazole, a broad-spectrum antifungal triazoles with activity against yeasts, molds, and dimorphic fungi and available as intravenous solution and as capsules for oral administration. Isavuconazonium sulfate is metabolized mainly by serum butylcholinesterase to isavuconazole. Isavuconazole is metabolized to inactive metabolites in the liver via CYP3A4 and CYP3A5 isoenzymes and uridine diphosphate-glucuronosyl transferase[1].
References
[1] Kumar, Sunil et al. “11. Thiazole: A privileged scaffold in drug discovery.” 2016. 0.
Isavuconazonium sulfate Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hangzhou ICH Biofarm Co., Ltd | +86-0571-28186870; +undefined8613073685410 | sales@ichemie.com | China | 1015 | 58 |
| Beijing Hope Pharmaceutical Co., Ltd. | +86-010-67886402 +8613611125266 | market@hopelife.cn | China | 72 | 58 |
| Wuhan Fortuna Chemical Co., Ltd | +86-027-59207850 | info@fortunachem.com | China | 5975 | 58 |
| Zhengzhou Anbu Chem Co.,Ltd | +86-0371-88006763; +8615988602810 | sales@anbuchem.com | China | 2998 | 58 |
| Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8615965530500 | nickzhang@hangyubiotech.com | China | 10983 | 58 |
| Shaanxi TNJONE Pharmaceutical Co., Ltd | +86-17396673057 | linda@tnjone.com | China | 1143 | 58 |
| BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD. | +86-18600796368 +86-18600796368 | sales@sjar-tech.com | China | 485 | 58 |
| Moxin Chemicals | +8617320513646 | Anna@molcoo.com | China | 10786 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29730 | 60 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21628 | 55 |
View Lastest Price from Isavuconazonium sulfate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-04-28 | Isavuconazonium sulfate
946075-13-4
|
US $0.00-0.00 / g | 10g | 99% | 10kg | WUHAN FORTUNA CHEMICAL CO., LTD | |
 |
2025-04-27 | Isavuconazole Sulfate
946075-13-4
|
US $0.00-0.00 / mg | 10mg | 95%+ | 100000 | Moxin Chemicals | |
 |
2025-04-22 | Isavuconazonium sulfate
946075-13-4
|
US $0.10-0.30 / kg | 1kg | 99% | 20 tons | Zibo Hangyu Biotechnology Development Co., Ltd |
-
- Isavuconazonium sulfate
946075-13-4
- US $0.00-0.00 / g
- 99%
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- Isavuconazole Sulfate
946075-13-4
- US $0.00-0.00 / mg
- 95%+
- Moxin Chemicals
-
- Isavuconazonium sulfate
946075-13-4
- US $0.10-0.30 / kg
- 99%
- Zibo Hangyu Biotechnology Development Co., Ltd
946075-13-4(Isavuconazonium sulfate)Related Search:
1of3