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Methyldopa

Methyldopa
Methyldopa
CAS No.
555-30-6
Chemical Name:
Methyldopa
Synonyms
amd;mkb51;MK-351;MEDOBA;aldomet;aldomin;dopamet;dopatec;dopegyt;medomet
CBNumber:
CB4277127
Molecular Formula:
C10H13NO4
Formula Weight:
211.21
MOL File:
555-30-6.mol

Methyldopa Properties

Melting point:
≥300 °C
Boiling point:
350.89°C (rough estimate)
Density 
1.2545 (rough estimate)
refractive index 
-14 ° (C=1, H2O)
storage temp. 
Store at RT
Merck 
14,6055
CAS DataBase Reference
555-30-6(CAS DataBase Reference)
EPA Substance Registry System
L-Tyrosine, 3-hydroxy-.alpha.-methyl-(555-30-6)

SAFETY

WGK Germany  3
RTECS  YP2860000
10-23
HS Code  29181990
Hazardous Substances Data 555-30-6(Hazardous Substances Data)

Methyldopa price More Price(6)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TCI Chemical D1817 3-(3,4-Dihydroxyphenyl)-2-methyl-L-alanine Sesquihydrate >98.0%(HPLC)(T) 555-30-6 5g $60 2018-11-22 Buy
TCI Chemical D1817 3-(3,4-Dihydroxyphenyl)-2-methyl-L-alanine Sesquihydrate >98.0%(HPLC)(T) 555-30-6 25g $180 2018-11-22 Buy
Cayman Chemical 21814 L-(?)-α-Methyldopa ≥98% 555-30-6 10g $88 2018-11-19 Buy
Cayman Chemical 21814 L-(?)-α-Methyldopa ≥98% 555-30-6 5g $49 2018-11-19 Buy
Cayman Chemical 21814 L-(?)-α-Methyldopa ≥98% 555-30-6 25g $196 2018-11-19 Buy

Methyldopa Chemical Properties,Uses,Production

Uses

Antihypertensor;L-aromatic aminoacid decarboxylase inhibitor

Uses

vitamin, coenzyme B12

Definition

ChEBI: A derivative of L-tyrosine having a methyl group at the alpha-position and an additional hydroxy group at the 3-position on the phenyl ring.

General Description

Colorless or almost colorless crystals or white to yellowish-white fine powder. Almost tasteless. In the sesquihydrate form. pH (saturated aqueous solution) about 5.0.

Air & Water Reactions

Very hygroscopic. Slightly water soluble. May be sensitive to prolonged exposure to air and light. The stability of aqueous solutions is markedly dependent on pH, oxygen and the amount of initial reactant. Aqueous solutions are stable for up to 50 hours in acid and neutral pH (6.2). At pH 8.0, decomposition products are formed in 3 to 5 hours. Solutions develop a red tint that becomes progressively darker (eventually forming a black precipitate).

Reactivity Profile

Methyldopa undergoes catalytic oxygenation in the presence of magnesium, cupric, cobalt, nickel and ferric ions . A weakly acidic amino acid.

Fire Hazard

Flash point data for Methyldopa are not available; however, Methyldopa is probably combustible.

Biological Activity

L-aromatic amino acid decarboxylase inhibitor. Antihypertensive.

Safety Profile

Poison by intraperitoneal route. Moderately toxic by ingestion and intravenous routes. Human systemic effects by ingestion: fasciculations, hallucinations, distorted perceptions, tremors, allergic dermatitis, necrotic gastrointestinal changes. An experimental teratogen. Human reproductive effects: menstrual cycle changes or disorders, effects on newborn including abnormal neonatal measures and growth statistics, biochemical and metabolic changes. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx

Purification Methods

Recrystallise methyldopa from H2O. [Reinhold et al. J Org Chem 33 1209 1968.] The L-isomer forms a sesquihydrate from H2O m 302-304o (dec), and the anhydrous crystals are hygroscopic,[] 23D -4.0o (c 1, 0.1N HCl), []546 +154.5o (c 5, CuSO4 solution). It has max at 281nm ( 2780). Its solubility in H2O at 25o is ~10mg/mL and the pH of an aqueous solution is ~5.0. It is insoluble in most organic solvents. [Stein et al. J Am Chem Soc 77 700 1955, Beilstein 4 IV 2505.]

Methyldopa Preparation Products And Raw materials

Raw materials

Preparation Products


Methyldopa Suppliers

Global( 182)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
0755-23311925 Abel@chembj.com CHINA 3217 55
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 22058 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20795 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32763 55
Jinan Jianfeng Chemical Co., Ltd
15562555968
info@pharmachemm.com CHINA 617 58
Shanghai Boyle Chemical Co., Ltd. Mr Qiu:021-50182298(Demestic market) Miss Xu:021-50180596(Abroad market)
+86-21-57758967 sales@boylechem.com China 2220 55
J & K SCIENTIFIC LTD. 400-666-7788 +86-10-82848833
+86-10-82849933 jkinfo@jkchemical.com;market6@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. +86-(0)21-61259100(Shanghai) +86-(0)755-86170099(ShenZhen) +86-(0)10-62670440(Beijing)
+86-(0)21-61259102(Shanghai) +86-(0)755-86170066(ShenZhen) +86-(0)10-88580358(Beijing) sh@meryer.com China 40398 62
3B Pharmachem (Wuhan) International Co.,Ltd. 86-21-50328103 * 801、802、803、804 Mobile:18930552037
86-21-50328109 3bsc@sina.com China 15940 69
TCI (Shanghai) Development Co., Ltd. 021-67121386 / 800-988-0390
021-67121385 Sales-CN@TCIchemicals.com China 24653 81

555-30-6(Methyldopa)Related Search:


  • L-A-METHYL DOPA MK-351, METHYLDOPA
  • MethyldopaUsp28/Bp2003/Ep5
  • 3-Hydroxy-α-methyl-L-tyrosine
  • L-Tyrosine, 3-hydroxy-.alpha.-methyl-
  • 2-METHYL-3-(3,4-DIHYDROXYPHENYL)ALANINE
  • Methyldopa (EDMF/COS)
  • (2S)-2-Amino-3-(3,4-dihydroxyphenyl)-2-methylpropanoic acid
  • 3-(3,4-Dihydroxyphenyl)-α-methyl-L-alanine
  • ethyldopa
  • Methyldopa L
  • L-Tyrosine, 3-hydroxy-a-Methyl-
  • L-_-_-&alpha
  • 3-(3,4-Dihydroxyphenyl)-2-methyl-L-alanine Sesquihydrate
  • MK-351
  • L-(-)-ALPHA-METHYLDOPA
  • L-ALPHA-METHYL-DOPA
  • L-3-(3,4-DIHYDROXYPHENYL)-2-METHYLALANINE
  • MEDOBA
  • L-METHYLDOPA
  • METHYL DOPA
  • METHYL-L-DOPA
  • ALPHA-METHYL-L-DOPA
  • ALPHA-METHYL-L-BETA-3,4-DIHYDROXYPHENYLALANINE
  • 3-(3,4-DIHYDROXYPHENYL)-ALPHA-METHYL-L-ALANINE
  • 3-(3,4-DIHYDROXYPHENYL)-2-METHYL-L-ALANINE
  • 2-METHYL-3-(3,4-DIHYDROXYPHENYL)-L-ALANINE
  • 2-AMINO-3-(3,4-DIHYDROXYPHENYL)-2-METHYL-PROPANOIC ACID
  • 3-hydroxy-alpha-methyl-l-tyrosin
  • 3-hydroxy-alpha-methyl-l-tyrosine
  • 3-Hydroxy-methyl-L-tyroxine
  • 4-dihydroxyphenyl)-2-methyl-3-(l-(-)-alanin
  • aldomet
  • aldometil
  • aldomin
  • alphamedopa
  • alpha-methyl-beta-(3,4-dihydroxyphenyl)-l-alanine
  • alpha-methyl-l-3,4-dihydroxyphenylalanine
  • amd
  • bayer1440l
  • baypresol
  • dopamet
  • dopatec
  • dopegyt
  • l-(-)-alpha-methyl-beta-(3,4-dihydroxyphenyl)alanine
  • l(-)-beta-(3,4-dihydroxyphenyl)-alpha-methylalanine
  • l-(alpha-md)
  • l-2-amino-2-methyl-3-(3,4-dihydroxyphenyl)propionicacid
  • l-3-(3,4-Dihydroxyophenyl)-2-methylalanine
  • l-alpha-methyl-3,4-dihydroxyphenylalanine
  • l-alpha-methyldop
  • medomet
  • medopren
  • methoplain
  • mkb51
  • nci-c55721
  • nr.c2294
  • nrc2294
  • presinol
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