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Theophylline

Theophylline
Theophylline structure
CAS No.
58-55-9
Chemical Name:
Theophylline
Synonyms
asmax;X 115;austyn;Nuelin;Elixex;unidur;Unifyl;accurb;nsc2066;Respbid
CBNumber:
CB4285388
Molecular Formula:
C7H8N4O2
Formula Weight:
180.16
MOL File:
58-55-9.mol

Theophylline Properties

Melting point:
271-273 °C
Boiling point:
312.97°C (rough estimate)
Density 
1.3640 (rough estimate)
refractive index 
1.6700 (estimate)
Flash point:
11 °C
storage temp. 
2-8°C
solubility 
0.1 M HCl: soluble
form 
powder
pka
8.77(at 25℃)
color 
white
Water Solubility 
8.3 g/L (20 ºC)
Merck 
14,9285
BRN 
13463
Stability:
Stable. Incompatible with strong oxidizing agents.
InChIKey
ZFXYFBGIUFBOJW-UHFFFAOYSA-N
CAS DataBase Reference
58-55-9(CAS DataBase Reference)
NIST Chemistry Reference
1,3-Dimethylxanthine(58-55-9)
EPA Substance Registry System
1H-Purine-2,6-dione, 3,7-dihydro-1,3-dimethyl-(58-55-9)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  Xn,T,F,Xi
Risk Statements  22-39/23/24/25-23/24/25-11-36/37/38
Safety Statements  7-16-36/37-45-36-26-24/25
RIDADR  UN 2811 6.1/PG 3
WGK Germany  1
RTECS  XH3850000
10-23
TSCA  Yes
HazardClass  6.1(b)
PackingGroup  III
HS Code  29395900
Hazardous Substances Data 58-55-9(Hazardous Substances Data)
Symbol(GHS):
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H225 Highly Flammable liquid and vapour Flammable liquids Category 2 Danger P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H301 Toxic if swalloed Acute toxicity,oral Category 3 Danger P264, P270, P301+P310, P321, P330,P405, P501
H370 Causes damage to organs Specific target organ toxicity, single exposure Category 1 Danger P260, P264, P270, P307+P311, P321,P405, P501
Precautionary statements:
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P311 Call a POISON CENTER or doctor/physician.
P321 Specific treatment (see … on this label).
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P405 Store locked up.

Theophylline price More Price(19)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 1653117 Theophylline melting point standard United States Pharmacopeia (USP) Reference Standard 58-55-9 500mg $235 2018-11-20 Buy
Sigma-Aldrich 1653004 Theophylline 58-55-9 200mg $352.8 2018-11-20 Buy
TCI Chemical T0179 Theophylline >98.0%(HPLC)(T) 58-55-9 25g $13 2018-11-22 Buy
TCI Chemical T0179 Theophylline >98.0%(HPLC)(T) 58-55-9 100g $24 2018-11-22 Buy
Alfa Aesar J60203 Theophylline 58-55-9 2.27kg $223 2018-11-13 Buy

Theophylline Chemical Properties,Uses,Production

Chemical Properties

white to light yellow crystal powder

Uses

Xanthine derivative with diuretic, cardiac stimulant and smooth muscle relaxant activities; isomeric with theobromine. Small amounts occur in tea. Bronchodilator.

Uses

theophylline is tonic and skin conditioning. Its cosmetic activity is not clearly or definitively established. It is most often found in anti-cellulite products. Theophylline is in the same family of bio chemicals as caffeine. It is naturally occurring in tea.

Definition

ChEBI: A dimethylxanthine having the two methyl groups located at positions 1 and 3. It is structurally similar to caffeine and is found in green and black tea.

Indications

Twenty years ago theophylline (Theo-Dur, Slo-bid, Uniphyl, Theo-24) and its more soluble ethylenediamine salt, aminophylline, were the bronchodilators of choice in the United States. Although the β2-adrenoceptor agonists now fill this primary role, theophylline continues to have an important place in the therapy of asthma because it appears to have antiinflammatory as well as bronchodilator activity.

General Description

Odorless white crystalline powder. Odorless. Bitter taste.

Air & Water Reactions

Slightly soluble in water.

Reactivity Profile

Theophylline neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.

Hazard

Questionable carcinogen.

Fire Hazard

Flash point data for Theophylline are not available, however Theophylline is probably combustible.

Biological Activity

Bronchodilator, anti-inflammatory and immunomodulator. Antagonizes adenosine receptors and is a weak non-selective inhibitor of phosphodiesterases (PDEs).

Pharmacology

Smooth muscle relaxation, central nervous system (CNS) excitation, and cardiac stimulation are the principal pharmacological effects observed in patients treated with theophylline.The action of theophylline on the respiratory system is easily seen in the asthmatic by the resolution of obstruction and improvement in pulmonary function. Other mechanisms that may contribute to the action of theophylline in asthma include antagonism of adenosine, inhibition of mediator release, increased sympathetic activity, alteration in immune cell function, and reduction in respiratory muscle fatigue. Theophylline also may exert an antiinflammatory effect through its ability to modulate inflammatory mediator release and immune cell function.
Inhibition of cyclic nucleotide phosphodiesterases is widely accepted as the predominant mechanism by which theophylline produces bronchodilation. Phosphodiesterases are enzymes that inactivate cAMP and cyclic guanosine monophosphate (GMP), second messengers that mediate bronchial smooth muscle relaxation.

Clinical Use

The principal use of theophylline is in the management of asthma. It is also used to treat the reversible component of airway obstruction associated with chronic obstructive pulmonary disease and to relieve dyspnea associated with pulmonary edema that develops from congestive heart failure.

Side effects

Theophylline has a narrow therapeutic index and produces side effects that can be severe, even life threatening. Importantly, the plasma concentration of theophylline cannot be predicted reliably from the dose. In one study, the oral dosage of theophylline required to produce therapeutic plasma levels (i.e., between 10 and 20 μg/mL) varied between 400 and 3,200 mg/day. Heterogeneity among individuals in the rate at which they metabolize theophylline appears to be the principal factor responsible for the variability in plasma levels. Such conditions as heart failure, liver disease, and severe respiratory obstruction will slow the metabolism of theophylline.

Safety Profile

Human poison by ingestion, parenteral, intravenous, and rectal routes. Experimental poison by multiple routes. An experimental teratogen. Human systemic effects: coma, convulsions or effect on seizure threshold, cyanosis, EKG changes, fever and other metabolic effects, heart arrhythmias, heart rate change, hyperglycemia, metabolic acidosis, nausea or vomiting, potassium-level changes, respiratory stimulation, salivary gland changes, somnolence, tremor. Experimental reproductive effects. Human mutation data reported. Used as a dturetic, cardtac stimulant, smooth muscle relaxant, and to treat asthma. When heated to decomposition it emits toxic fumes of NOx.

Purification Methods

It crystallises from H2O as the monohydrate which becomes anhydrous above 100o. It is freely soluble in hot H2O, but its solubility at 15o is 0.44%. It complexes with heavy metals. It is a diuretic, vasodilator and a cardiac stimulant. [Lister Purines Part II, Fused Pyrimidines Brown Ed, Wiley-Interscience pp253-254 1971, ISBN 0-471-38205-1, Beilstein 26 H 455, 26 I 134, 26 II 263, 26 III/IV 2331.]

Precautions

Theophylline should be used with caution in patientswith myocardial disease, liver disease, and acutemyocardial infarction. The half-life of theophylline isprolonged in patients with congestive heart failure.Because of its narrow margin of safety, extreme cautionis warranted when coadministering drugs, such as cimetidineor zileuton, that may interfere with the metabolismof theophylline. Indeed, coadministration of zileutonwith theophylline is contraindicated. It is alsoprudent to be careful when using theophylline in patientswith a history of seizures.

Theophylline Preparation Products And Raw materials

Raw materials

Preparation Products


Theophylline Suppliers

Global( 274)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Capot Chemical Co.,Ltd.
+86 (0)571-855 867 18
+86 (0)571-858 647 95 sales@capotchem.com China 19919 60
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21924 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20680 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32457 55
Hangzhou FandaChem Co.,Ltd.
0086 158 5814 5714 (Mobile; WhatsApp; Telegram)
+86-571-56059825 fandachem@gmail.com CHINA 2597 55
Hubei XinRunde Chemical Co., Ltd.
+8615102730682; +8618874586545
02783214688 bruce@xrdchem.cn CHINA 541 55
Hebei Aicrowe Biotech Co., Ltd
0311-66855331
aicrowe@kf-chem.com CHINA 308 58
Xiamen AmoyChem Co., Ltd
+86 (0)592-605 1114
sales@amoychem.com CHINA 6374 58
Hebei Chisure Biotechnology Co., Ltd.
+8613091036086; +8613292890173
+8613292893290 sandy@speedgainpharma.com; luna@speedgainpharma.com CHINA 1019 58
Shanghai Zheyan Biotech Co., Ltd.
18017610038
zheyansh@163.com CHINA 3623 58

View Lastest Price from Theophylline manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2019-05-15 99% High purity Theophylline TOP1 supplier in China CAS NO.58-55-9 kf-wang(at)kf-chem.com
58-55-9
US $25.00 / Kg/Drum 10g 99.8% 5000 Hebei Aicrowe Biotech Co., Ltd
2019-05-15 Theophylline
58-55-9
US $1.00 / KG 1g 99% 500 Hebei Aicrowe Biotech Co., Ltd
2018-08-15 Theophylline
58-55-9
US $1.00 / KG 1G 98% 100KG career henan chemical co

Theophylline Spectrum


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