Rabbit anti-EGFR Antibody, Affinity Purified
- CAS No.
- Chemical Name:
- Rabbit anti-EGFR Antibody, Affinity Purified
- Synonyms
- Rabbit anti-EGFR Antibody, Affinity Purified
- CBNumber:
- CB42890597
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MOL File:
- Mol file
Rabbit anti-EGFR Antibody, Affinity Purified price More Price(1)
Rabbit anti-EGFR Antibody, Affinity Purified Chemical Properties,Uses,Production
General Description
Epidermal growth factor receptor (EGFR, ErbB1) is a transmembrane protein that exerts tyrosine kinase activity upon ligand induced activation. EGFR can be activated by binding EGF or at least six other structurally related protein ligands, including transforming growth factor α (TGFα), heparin-binding EGF-like growth factor (HB-EGF), betacellulin (BTC), amphiregulin, epiregulin and epigen. The gene encoding it is localized on human chromosome 7p11.2.
Biochem/physiol Actions
Upon activation by ligands, epidermal growth factor receptor (EGFR, ErbB1) initiates a signaling cascade which includes dimerization and internalization, tyrosine phosphorylation, DNA synthesis of target genes, and, ultimately, cell proliferation. EGFR signaling plays a role in the growth and differentiation of normal cells, but elevated EGFR activity is correlated with the development and pathogenesis of certain cancers.
Rabbit anti-EGFR Antibody, Affinity Purified Preparation Products And Raw materials
Raw materials
Preparation Products
Rabbit anti-EGFR Antibody, Affinity Purified Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
Supplier | Advantage |
---|---|
Sigma-Aldrich | 80 |