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CYMARIN

CYMARIN
CYMARIN structure
CAS No.
508-77-0
Chemical Name:
CYMARIN
Synonyms
CYMARIN;CIMARIN;KOMBETIN;CYMARINE;WV-90043a;alvonalmr;CYMARIN(P);K STROPHANTHIN;STROPHANTHIN K;K-STROPHANTHIN-A
CBNumber:
CB4291060
Molecular Formula:
C30H44O9
Formula Weight:
548.66
MOL File:
508-77-0.mol

CYMARIN Properties

Melting point:
148°C
alpha 
D20 +39.2° (methanol); D22 +39.0° (c = 1.7 in chloroform)
Boiling point:
540.83°C (rough estimate)
Density 
1.1277 (rough estimate)
refractive index 
1.5500 (estimate)
storage temp. 
2-8°C
pka
13.55±0.70(Predicted)
BRN 
101370
FDA UNII
UK3LS8435E
ATC code
C01AC03
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS06,GHS08
Signal word  Danger
Hazard statements  H301+H331-H373
Precautionary statements  P261-P301+P310-P311
Hazard Codes  T,T+
Risk Statements  23/25-33-26/27/28-41
Safety Statements  45-36/37/39-36/37-28-26
RIDADR  UN 3462 6.1/PG 2
WGK Germany  3
RTECS  GZ5600000
8-10-23
HazardClass  6.1(b)
PackingGroup  III
Toxicity LD50 i.v. in rats: 24.8±1.8 mg/kg (Vogel, Kluge)

CYMARIN price More Price(3)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 30030 Cymarin ≥96% (HPLC) 508-77-0 1mg $121 2021-03-22 Buy
Sigma-Aldrich 30030 Cymarin ≥96% (HPLC) 508-77-0 5mg $410 2021-03-22 Buy
Sigma-Aldrich PHL89838 Cymarin phyproof Reference Substance 508-77-0 20mg $171 2021-03-22 Buy

CYMARIN Chemical Properties,Uses,Production

Originator

Alvonal,Goumldecke

Manufacturing Process

Finely ground seeds of Castilloa elastica (3550 g) are percolated with sufficient light petroleum (boiling point 60°-80°C) to ensure removal of all the fat. The mart is dried with a current of air and percolated with chloroform until no further color is obtained with alkaline m-dinitrobenzene. The percolate is evaporated under reduced pressure, the residue triturated with dry ether (750 ml) and filtered. The residue (69.75 g) is washed with dry ether, dried, and some of the washed residue (20 g) is dissolved in a benzene-chloroform mixture (50 ml), comprising one part benzene to two parts chloroform by volume, and is absorbed on to a column of alumina (7x32 cm), previously deactivated with 10% acetic acid [hereinafter referred to as Column (l)] and eluted with the same solvent mixture.
The compositions of the following fractions (collected from Column (I)) are identified by paper chromatography using Whatman No. 1 paper [Registered Trade Mark] and the aforementioned benzene-chloroform mixture.
Column (I). Fraction: (a) a pigment; (b) a substance of Rf 0.66; (c) a small quantity of a substance of Rf 0.66 and a substance of Rf 0.45; (d) a substance of Rf 0.45.
Fraction (c) is obtained from the column and concentrated. The solid residue is dissolved in the aforementioned benzene-chloroform mixture (15 ml) and fractionated further on a second deactivated alumina column (4x30cm). From this column [hereinafter referred to as Column (II)] the following fractions are collected and identified using the same chromatographic system as was used for identifying the fractions of Column (I).
Column (II). Fraction: (a) a substance of Rf 0.66; (b) a trace of a substance of Rf 0.66; (c) a substance of Rf 0.45.
The fractions (d) of Column (I) and (c) of Column (II) are combined and evaporated and the residue (80 g) crystallized from methanol and ether followed by further re-crystallization from dilute alcohol. On heating to 120°C under a pressure of 0.01 mm/Hg, the crystals Iost water to give a compound, cymarin, which has an [α]d 22 =+39.0°. The [α]d 20 of cymarin (obtained from another source) in methanol is + 39.3°.
Alternatively, fractional crystallization may be used in place of adsorption chromatography
Cumarin may be also prepared from seeds of Strophantus Kombe

Therapeutic Function

Cardiotonic

CYMARIN Preparation Products And Raw materials

Raw materials

Preparation Products


CYMARIN Suppliers

Global( 39)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Shanghai Zheyan Biotech Co., Ltd.
18017610038
zheyansh@163.com CHINA 3623 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 29954 58
Hubei xin bonus chemical co. LTD
86-13657291602
027-59338440 linda@hubeijusheng.com CHINA 23035 58
Chongqing Chemdad Co., Ltd
+86-13650506873
sales@chemdad.com CHINA 37282 58
Hubei Ipure Biology Co., Ltd
+8618062405514
18062427325 ada@ipurechemical.com;ada@ipurechemical.com China 10352 58
HONG KONG IPURE BIOLOGY CO.,LIMITED
18062405514 86 18062405514
ada@ipurechemical.com CHINA 3475 58
Dideu Industries Group Limited
029-88380327
Service@dideu.com CHINA 30013 58
Meryer (Shanghai) Chemical Technology Co., Ltd. 400-660-8290 21-61259100-
86-21-61259102 sh@meryer.com China 40264 62
ChemStrong Scientific Co.,Ltd 15920483169 0755-66853366-
sales@chem-strong.com China 26487 56
Alfa Chemistry 516-662-5404
1-516-927-0118 inquiry@alfa-chemistry.com United States 9956 60

View Lastest Price from CYMARIN manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2019-07-06 cymarin
508-77-0
US $1.00 / KG 1g 99% 100KG career henan chemical co

CYMARIN Spectrum


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