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Felodipine

CAS No.
72509-76-3
Chemical Name:
Felodipine
Synonyms
FEXOFENADINE HCL;Plendil;Felodipin;Agon;modip;Hydac;Spendil;CGH-869;P|endil;h154/82
CBNumber:
CB4300661
Molecular Formula:
C18H19Cl2NO4
Molecular Weight:
384.25
MDL Number:
MFCD08235033
MOL File:
72509-76-3.mol
MSDS File:
SDS
Last updated:2023-10-10 18:06:03

Felodipine Properties

Melting point 142-145°C
Boiling point 471.5±45.0 °C(Predicted)
Density 1.3506 (rough estimate)
refractive index 1.6500 (estimate)
storage temp. 2-8°C
solubility DMSO: 28 mg/mL
form solid
pka 2.73±0.70(Predicted)
color light yellow
Water Solubility insoluble
Stability Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
InChI InChI=1S/C18H19Cl2NO4/c1-5-25-18(23)14-10(3)21-9(2)13(17(22)24-4)15(14)11-7-6-8-12(19)16(11)20/h6-8,15,21H,5H2,1-4H3
InChIKey RZTAMFZIAATZDJ-UHFFFAOYSA-N
SMILES C1(C)NC(C)=C(C(OC)=O)C(C2=CC=CC(Cl)=C2Cl)C=1C(OCC)=O
CAS DataBase Reference 72509-76-3(CAS DataBase Reference)
FDA UNII OL961R6O2C
NIST Chemistry Reference Felodipine(72509-76-3)
ATC code C08CA02

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P301+P312+P330
Hazard Codes  Xn
Risk Statements  22
Safety Statements  36
RIDADR  UN 3077 9 / PGIII
WGK Germany  3
RTECS  US7968700
HS Code  29333990
NFPA 704
0
3 0

Felodipine price More Price(55)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich F9677 Felodipine solid 72509-76-3 5mg $131 2024-03-01 Buy
Sigma-Aldrich BP777 Felodipine British Pharmacopoeia (BP) Reference Standard 72509-76-3 100MG $229 2024-03-01 Buy
Sigma-Aldrich BP758 Felodipine impurity standard British Pharmacopoeia (BP) Reference Standard 72509-76-3 20MG $251 2024-03-01 Buy
Sigma-Aldrich 1269389 Felodipine United States Pharmacopeia (USP) Reference Standard 72509-76-3 300mg $436 2024-03-01 Buy
Sigma-Aldrich BP758 Felodipine impurity standard British Pharmacopoeia (BP) Reference Standard 72509-76-3 BP758 $246 2023-06-20 Buy
Product number Packaging Price Buy
F9677 5mg $131 Buy
BP777 100MG $229 Buy
BP758 20MG $251 Buy
1269389 300mg $436 Buy
BP758 BP758 $246 Buy

Felodipine Chemical Properties,Uses,Production

Description

Felodipine is a vasodilatory calcium antagonist with a high degree of vascular selectivity. It is currently indicated for use only in hypertension, either as monotherapy or in conjunction with diuretics or beta blockers.

Chemical Properties

White or Light Yellow Crystalline Powder

Originator

Astra (Sweden)

Uses

Zanarnivir influenza prophylaxis and therapy

Uses

vasodilator, Ca channel blocker

Uses

Felodipine is used as a dihydropyridine calcium channel blocker. It displays high vascular selectivity; lowers arterial blood pressure without altering cardiac contractility. Antihypertensive.

Definition

ChEBI: The mixed (methyl, ethyl) diester of 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid. A calcium-channel blocker, it lowers blood pressure by reducing peripheral vascular resistance through a highly selective action on smooth m scle in arteriolar resistance vessels. It is used in the management of hypertension and angina pectoris.

Manufacturing Process

Preparation of 2,3-dichlorobenzylideneacetylacetic acid-methylester.
2,3-Dichlorobenzaldehyde is reacted with methyl acetoacetate in a suitable solvent in the presence of a catalytic amount of acetic acid and piperidine. Water is azeotropically separated off during the reaction. The reaction mixture is extracted in order to remove the catalysts. The solvent is evaporated and methanol is added. The product is crystallized by cooling the solution, isolated by filtration and finally washed with methanol.

brand name

Plendil (AstraZeneca).

Therapeutic Function

Antihypertensive

General Description

Felodipine, 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid ethylmethyl ester (Plendil), is a second-generation dihydropyridinechannel blocker of the nifedipine type. It is more selectivefor vascular smooth muscle than for myocardial tissueand serves as an effective vasodilator.

Biological Activity

L-type Ca 2+ channel blocker that is selective over N-, R-, P/Q- and T-type channels. Displays high vascular selectivity; lowers arterial blood pressure without altering cardiac contractility. Antihypertensive.

Clinical Use

Felodipine is used inthe treatment of angina and mild-to-moderate essential hypertension.Felodipine, like most of the dihydropyridines,exhibits a high degree of protein binding and has a half-liferanging from 10 to 18 hours.

storage

+4°C

References

1) Todd and Faulds, (1992)?Felodipine. A review of the pharmacology and therapeutic use of the extended release formulation in cardiovascular disorders; Drugs?44?251 2) Furukawa?et al. (1999)?Selectivities of Dihydropyridine Derivatives in Blocking Ca2+ Channel Subtypes Expressed in Xenopus Oocytes; J. Pharmacol. Exp. Ther.?291?464

626-34-6
105-45-3
6334-18-5
72509-76-3
Synthesis of Felodipine from ETHYL 3-AMINOCROTONATE and Methyl acetoacetate and 2,3-Dichlorobenzaldehyde
Global( 502)Suppliers
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View Lastest Price from Felodipine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
felodipine pictures 2023-10-10 felodipine
72509-76-3
US $0.00 / kg 1kg 0.99 20tons Hebei Yanxi Chemical Co., Ltd.
Felodipine pictures 2023-09-06 Felodipine
72509-76-3
US $0.00 / KG 1KG 99% 50000KG/month Hebei Mojin Biotechnology Co., Ltd
Felodipine pictures 2023-06-26 Felodipine
72509-76-3
US $200.00 / kg 10kg 99% 500kg/month Hebei Mingeng Biotechnology Co., Ltd
  • felodipine pictures
  • felodipine
    72509-76-3
  • US $0.00 / kg
  • 0.99
  • Hebei Yanxi Chemical Co., Ltd.
  • Felodipine pictures
  • Felodipine
    72509-76-3
  • US $0.00 / KG
  • 99%
  • Hebei Mojin Biotechnology Co., Ltd
  • Felodipine pictures
  • Felodipine
    72509-76-3
  • US $200.00 / kg
  • 99%
  • Hebei Mingeng Biotechnology Co., Ltd

Felodipine Spectrum

,ethylmethylester ethylmethyl4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedica 4-(2,3-Dichlorophenyl)-2,6-dimethyl-1,4-dihydro-3,5-pyridinedicarboxylic acid methyl ethyl ester Fjodil:Hydac P|endil 4-(2,3-Dichlorophenyl)-1,4-dihydro-2,6-dimethyl-5-methoxycarbonyl-3-pyridinecarboxylic acid ethyl ester CGH-869 Spendil 4-(2,3-Dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylicacidethylmethylester Felodipine,4-(2,3-Dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinecarboxylic acid ethyl methyl ester, Plendil Felodipine (300 mg) Felodipine (200 mg) Felodipine/Plendil 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-4-(2,3-dichlorophenyl)-2,6-dimethyl-, ethyl methyl ester Ethyl methyl 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate Felodipine, USP Felodipine API 4-(2,3-Dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic Acid Ethyl Methyl Ester Ethyl Methyl 4-(2,3-Dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate 3-ethyl 5-Methyl 4-(2',3'-dichlorophenyl)-2,6-diMethyl-1,4-dihydropyridine-3,5-dicarboxylate Clevidipine Butyrate iMpurity Ⅱ 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid-3-ethyl 5-methyl ester 4-(2,3-Dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinecarboxylic acid ethyl methyl ester Cleviprex Impurity E Plendil, 4-(2,3-Dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinecarboxylic acid ethyl methyl ester h154/82 modip 4-(2,3-dichlorophenyl)-1,4-dihyro-2,6-dimethyl-3,5-pyridinedicarboxylic acid ethyl methyl ester FelodipineUsp25DmfGmp 4-(2,3-Dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic Acid, Methyl Ester, Feloday, Flodil, (RS)-Felodipine 3,5-Pyridinedicarboxylic acid, 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-, ethyl methyl ester Agon dl-Felodipine Hydac Munobal Splendil Felodipine Felodipine (1269389) FelodipineQ: What is Felodipine Q: What is the CAS Number of Felodipine Q: What is the storage condition of Felodipine Q: What are the applications of Felodipine Felodipine (CGH869) Felodipine USP/EP/BP Hot selling high quality Felodipine 3,5-Pyridinedicarboxylic acid, 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-, 3-ethyl 5-methyl ester odipine Felodipine> Felodipine CRS Felodipine, ≥98.0% Felodipine, 98%, Selective L-type Ca2+ channel blocker Clevidipine Butyrate Impurity 2 Felodipine, 98%, a selective L-type Ca2+ channel blocker Clevidipine Impurity E FEXOFENADINE HCL Felodipin Plendil 72509-76-3 72509-76-3;8618 C18H19Cl2NO4 C18H19NO4Cl2