ChemicalBook >> CAS DataBase List >>ODM-201

ODM-201

CAS No.
1297538-32-9
Chemical Name:
ODM-201
Synonyms
Darolutamide;BAY-1841788;0DM021;ODM 021;ODM-201;CS-1565;ODM-021;Darolutamid;Darolutamide D4;ODM-201(BAY-1841788)
CBNumber:
CB43052901
Molecular Formula:
C19H19ClN6O2
Molecular Weight:
398.85
MDL Number:
MFCD29472270
MOL File:
1297538-32-9.mol

ODM-201 Properties

Melting point 169 - 171°C
Boiling point 719.5±60.0 °C(Predicted)
Density 1.41±0.1 g/cm3(Predicted)
storage temp. -20°C Freezer, Under inert atmosphere
solubility DMSO (Slightly), Methanol (Slightly)
pka 11.10±0.10(Predicted)
form Solid
color White to Off-White
FDA UNII X05U0N2RCO
NCI Dictionary of Cancer Terms darolutamide
NCI Drug Dictionary darolutamide
ATC code L02BB06

ODM-201 price More Price(26)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 25643 ODM-201 ≥98% 1297538-32-9 1mg $39 2022-04-27 Buy
Cayman Chemical 25643 ODM-201 ≥98% 1297538-32-9 5mg $152 2022-04-27 Buy
Cayman Chemical 25643 ODM-201 ≥98% 1297538-32-9 10mg $285 2022-04-27 Buy
Cayman Chemical 25643 ODM-201 ≥98% 1297538-32-9 25mg $616 2022-04-27 Buy
TRC O006500 ODM-201 1297538-32-9 100mg $1890 2021-12-16 Buy
Product number Packaging Price Buy
25643 1mg $39 Buy
25643 5mg $152 Buy
25643 10mg $285 Buy
25643 25mg $616 Buy
O006500 100mg $1890 Buy

ODM-201 Chemical Properties,Uses,Production

Description

ODM-201 is an androgen receptor (AR) antagonist (Ki = 11 nM). It inhibits AR transactivation in U2OS osteosarcoma cells expressing human wild-type and mutant ARs (IC50s = 65, 66, 1,500, and 1,782 nM for wild-type, ARF876L, ARW741L, and ART877A, respectively). ODM-201 prevents androgen-induced AR nuclear translocation in AR-overexpressing HS-HEK293 and LNCaP cells and suppresses androgen-induced proliferation of VCaP cells (IC50 = 230 nM). In vivo, ODM-201 (50 mg/kg per day) reduces tumor growth in a VCaP castrated mouse xenograft model. It also inhibits tumor growth without increasing serum testosterone levels in a VCaP intact mouse xenograft model.

Description

ODM-201 is a novel androgen receptor (AR) inhibit designed to inhibit the growth of prostate cancer cells through binding to the AR to inhibit the testosterone-induced AR nuclear translocation. It is particularly used in patients with progressive metastatic castration-resistant prostate cancer. It is effective in inhibiting the activity of some mutant ARs emerging during antiandrogen therapies, including the F876L mutation version which is resistant to enzalutamide and ARN-509 (the second-generation antiandrogens).Therefore, it has potential to overcome the resistance issue occurring upon AR-targeted therapies.

Uses

ODM-201 is a compound being used as a novel next-generation androgen receptor-directed therapy for prostate cancer.

References

Moilanen, Anu Maarit, et al. "Discovery of ODM-201, a new-generation androgen receptor inhibitor targeting resistance mechanisms to androgen signaling-directed prostate cancer therapies." Sci Rep 5.2(2015):12007. Fizazi, Karim, et al. "ODM-201, a new generation androgen receptor inhibitor for castration-resistant prostate cancer: Preclinical and phase I data." Genitourinary Cancers Symposium of the Conquer-Cancer-Foundation of 2013. Fizazi, K, et al. "Activity and safety of ODM-201 in patients with progressive metastatic castration-resistant prostate cancer (ARADES): an open-label phase 1 dose-escalation and randomised phase 2 dose expansion trial." Lancet Oncology 5.9(2014):975-85.

Global( 132)Suppliers
Supplier Tel Email Country ProdList Advantage
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21975 55
Hangzhou FandaChem Co.,Ltd.
+8615858145714 fandachem@gmail.com China 9361 55
ATK CHEMICAL COMPANY LIMITED
21-51619050 ivan@atkchemical.com China 31281 60
career henan chemical co
+86-0371-86658258 sales@coreychem.com China 29922 58
Jinan Carbotang Biotech Co.,Ltd.
+8615866703830 figo.gao@foxmail.com China 4836 58
BOC Sciences
+16314854226 inquiry@bocsci.com United States 19588 58
Chongqing Chemdad Co., Ltd
+undefined-86-13650506873 +undefined-86-13650506873 sales@chemdad.com China 39915 58
Shenzhen Excellent Biotech Co., Ltd.
13480692018 ramyan@ex-biotech.com CHINA 954 58
ENBRIDGE PHARMTECH CO., LTD.
+8613812269233 tinayang@enbridgepharm.com China 243 58
SHANGHAI T&W PHARMACEUTICAL CO., LTD.
+86-021-61551611 +8615751773523 contact@trustwe.com China 4880 58

Related articles

  • Preparation of ODM-201
  • ODM-201 is a new generation AR inhibitor with superior preclinical efficacy compared to enzalutamide and bicalutamide, it does....
  • Nov 12,2019

View Lastest Price from ODM-201 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
ODM-201 pictures 2022-12-08 ODM-201
1297538-32-9
US $9.90-1277.00 / g 10g 99.99%HPLC.USP42——Powder、Oil、Pills、Capsules、Tablets,Customized packaging 100KG/Month Wuhan Biocar Pharmacy Co., Ltd.
ODM-201 pictures 2022-11-05 ODM-201
1297538-32-9
US $5.00-450.00 / G 1G 99.99% 1000kg Hebei Ningnan Trade Co. LTD
ODM-201 pictures 2022-06-30 ODM-201
1297538-32-9
US $285.00 / g 1g 98%+ 20tons Hebei Ruiyao Biotechnology Co. Ltd
  • ODM-201 pictures
  • ODM-201
    1297538-32-9
  • US $9.90-1277.00 / g
  • 99.99%HPLC.USP42——Powder、Oil、Pills、Capsules、Tablets,Customized packaging
  • Wuhan Biocar Pharmacy Co., Ltd.
  • ODM-201 pictures
  • ODM-201
    1297538-32-9
  • US $5.00-450.00 / G
  • 99.99%
  • Hebei Ningnan Trade Co. LTD
  • ODM-201 pictures
  • ODM-201
    1297538-32-9
  • US $285.00 / g
  • 98%+
  • Hebei Ruiyao Biotechnology Co. Ltd

1297538-32-9(ODM-201)Related Search:

ODM-201 N-[(1S)-2-[3-(3-Chloro-4-cyanophenyl)-1H-pyrazol-1-yl]-1-methylethyl]-5-(1-hydroxyethyl)-1H-pyrazole-3-carboxamide N-((S)-1-(3-(3-chloro-4-cyanophenyl)-1H-pyrazol-1-yl)propan-2-yl)-5-(1-hydroxyethyl)-1H-pyrazole-3-carboxamide Darolutamide (ODM-201) ODM-201(BAY-1841788) CS-1565 ODM-201(Darolutamide) N-{(2S)-1-[3-(3-chloro-4-cyanophenyl)-1H-pyrazol-1-yl]propan-2-yl}-5-[(1RS)-1-hydroxyethyl]-1H-pyrazole-3-carboxamide 0DM021 BAY-1841788;ODM-021;0DM021;ODM 021 ODM 021 ODM-021 DAROLUTAMIDE;BAY-1841788 1H-Pyrazole-3-carboxamide, N-[(1S)-2-[3-(3-chloro-4-cyanophenyl)-1H-pyrazol-1-yl]-1-methylethyl]-5-(1-hydroxyethyl)- Darolutamid Darolutamide D4 N-{(2S)-1-[3-(3-chloro-4-cyanophenyl)-1H-pyrazol-1-yl]propan-2-yl}-5-[(1RS)Chemicalbook-1-hydroxyethyl]-1H-pyrazole-3-carboxamide TIANFUCHEM--1297538-32-9---ODM-201 BAY-1841788 Darolutamide 1297538-32-9 C19H19ClN6O2 API