ODM-201
- CAS No.
- 1297538-32-9
- Chemical Name:
- ODM-201
- Synonyms
- Darolutamide;BAY-1841788;0DM021;ODM 021;ODM-201;CS-1565;ODM-021;Darolutamid;Darrolumide;Darolutamide D4
- CBNumber:
- CB43052901
- Molecular Formula:
- C19H19ClN6O2
- Molecular Weight:
- 398.85
- MDL Number:
- MFCD29472270
- MOL File:
- 1297538-32-9.mol
| Melting point | 169 - 171°C |
|---|---|
| Boiling point | 719.5±60.0 °C(Predicted) |
| Density | 1.41±0.1 g/cm3(Predicted) |
| storage temp. | -20°C Freezer, Under inert atmosphere |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| pka | 11.10±0.10(Predicted) |
| form | Solid |
| color | White to Off-White |
| NCI Dictionary of Cancer Terms | darolutamide |
| FDA UNII | X05U0N2RCO |
| NCI Drug Dictionary | darolutamide |
| ATC code | L02BB06 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS09 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H410-H302-H400 | |||||||||
| Precautionary statements | P264-P270-P301+P312-P330-P501-P273-P391-P501-P273-P391-P501 | |||||||||
| NFPA 704 |
|
ODM-201 price More Price(26)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 25643 | ODM-201 ≥98% | 1297538-32-9 | 1mg | $44 | 2024-03-01 | Buy |
| Cayman Chemical | 25643 | ODM-201 ≥98% | 1297538-32-9 | 5mg | $172 | 2024-03-01 | Buy |
| Cayman Chemical | 25643 | ODM-201 ≥98% | 1297538-32-9 | 10mg | $321 | 2024-03-01 | Buy |
| Cayman Chemical | 25643 | ODM-201 ≥98% | 1297538-32-9 | 25mg | $692 | 2024-03-01 | Buy |
| TRC | O006500 | ODM-201 | 1297538-32-9 | 100mg | $1890 | 2021-12-16 | Buy |
ODM-201 Chemical Properties,Uses,Production
Description
ODM-201 is an androgen receptor (AR) antagonist (Ki = 11 nM). It inhibits AR transactivation in U2OS osteosarcoma cells expressing human wild-type and mutant ARs (IC50s = 65, 66, 1,500, and 1,782 nM for wild-type, ARF876L, ARW741L, and ART877A, respectively). ODM-201 prevents androgen-induced AR nuclear translocation in AR-overexpressing HS-HEK293 and LNCaP cells and suppresses androgen-induced proliferation of VCaP cells (IC50 = 230 nM). In vivo, ODM-201 (50 mg/kg per day) reduces tumor growth in a VCaP castrated mouse xenograft model. It also inhibits tumor growth without increasing serum testosterone levels in a VCaP intact mouse xenograft model.
Description
ODM-201 is a novel androgen receptor (AR) inhibit designed to inhibit the growth of prostate cancer cells through binding to the AR to inhibit the testosterone-induced AR nuclear translocation. It is particularly used in patients with progressive metastatic castration-resistant prostate cancer. It is effective in inhibiting the activity of some mutant ARs emerging during antiandrogen therapies, including the F876L mutation version which is resistant to enzalutamide and ARN-509 (the second-generation antiandrogens).Therefore, it has potential to overcome the resistance issue occurring upon AR-targeted therapies.
Uses
ODM-201 is a compound being used as a novel next-generation androgen receptor-directed therapy for prostate cancer.
References
Moilanen, Anu Maarit, et al. "Discovery of ODM-201, a new-generation androgen receptor inhibitor targeting resistance mechanisms to androgen signaling-directed prostate cancer therapies." Sci Rep 5.2(2015):12007. Fizazi, Karim, et al. "ODM-201, a new generation androgen receptor inhibitor for castration-resistant prostate cancer: Preclinical and phase I data." Genitourinary Cancers Symposium of the Conquer-Cancer-Foundation of 2013. Fizazi, K, et al. "Activity and safety of ODM-201 in patients with progressive metastatic castration-resistant prostate cancer (ARADES): an open-label phase 1 dose-escalation and randomised phase 2 dose expansion trial." Lancet Oncology 5.9(2014):975-85.
ODM-201 Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Henan Bao Enluo International TradeCo.，LTD | +86-17331933971 +86-17331933971 | deasea125996@gmail.com | China | 2503 | 58 |
| Anhui Ruihan Technology Co., Ltd | +8617756083858 | daisy@anhuiruihan.com | China | 994 | 58 |
| Hebei Kangcang new material Technology Co., LTD | +8619133911216 | Jany1001@kangcang.com.cn | China | 338 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21695 | 55 |
| Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | fandachem@gmail.com | China | 9352 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 | figo.gao@foxmail.com | China | 6992 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
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View Lastest Price from ODM-201 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-04-18 | ODM-201
1297538-32-9
|
US $9.00-70.00 / g | 10g | 99% | 10 tons | Hebei Kangcang new material Technology Co., LTD | |
 |
2024-04-18 | ODM-201
1297538-32-9
|
US $40.00-35.00 / Gram | 1Gram | 99.99% | 50Tons | Hebei Dangtong Import and export Co LTD | |
 |
2023-08-22 | ODM-201
1297538-32-9
|
US $25.00 / kg | 1kg | 99% | 100tons | Anhui Ruihan Technology Co., Ltd |