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HYDROXYFLUTAMIDE

HYDROXYFLUTAMIDE structure

CAS No.: 52806-53-8

Chemical Name:: HYDROXYFLUTAMIDE

Synonyms: CS-1970;utamide;Sch-16423;Hydroxy FL;Hydroxyflutamid;HYDROXYFLUTAMIDE;hydroxyniphtholide;5-HYDROXYFLUTAMIDE;2-HYDROXY-FLUTAMIDE;Flutamide Impurity 7

CBNumber:: CB4307190

Molecular Formula:: C11H11F3N2O4

Molecular Weight:: 292.21

MDL Number:: MFCD00563126

MOL File:: 52806-53-8.mol

MSDS File:: SDS

Last updated:2023-06-08 09:02:15

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HYDROXYFLUTAMIDE Properties

Melting point	125-130°C
Boiling point	443.8±45.0 °C(Predicted)
Density	1.472
storage temp.	room temp
solubility	DMSO: >10mg/mL
pka	12.87±0.70(Predicted)
form	powder
color	white to tan
EWG's Food Scores	1
FDA UNII	31D90UKP5Y

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P264-P271-P280-P302+P352-P305+P351+P338

Hazard Codes

Risk Statements

36/37/38

Safety Statements

26-36/37/39

WGK Germany

RTECS

TX1466250

HS Code

2924297099

NFPA 704

	0
2		0

HYDROXYFLUTAMIDE price More Price(34)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	H4166	Hydroxyflutamide ≥98% (HPLC)	52806-53-8	5mg	$142	2024-03-01	Buy
Sigma-Aldrich	H4166	Hydroxyflutamide ≥98% (HPLC)	52806-53-8	25mg	$557	2024-03-01	Buy
TCI Chemical	H1600	Hydroxyflutamide >98.0%(HPLC)	52806-53-8	25mg	$278	2024-03-01	Buy
TCI Chemical	H1600	Hydroxyflutamide >98.0%(HPLC)	52806-53-8	100mg	$830	2024-03-01	Buy
Cayman Chemical	15271	2-hydroxy Flutamide ≥98%	52806-53-8	5mg	$81	2024-03-01	Buy

Product number	Packaging	Price	Buy
H4166	5mg	$142	Buy
H4166	25mg	$557	Buy
H1600	25mg	$278	Buy
H1600	100mg	$830	Buy
15271	5mg	$81	Buy

HYDROXYFLUTAMIDE Chemical Properties,Uses,Production

Description

2-hydroxy Flutamide is the major metabolite formed during the metabolism of the non-steroidal antiandrogen flutamide by cytochrome P450 (CYP) isoforms CYP1A2 and CYP3A4. Through competitive inhibition of the binding of testosterone to the nuclear androgen receptor (AR; IC₅₀ = ~300-900), 2-hydroxy flutamide blocks the expression of AR target genes and prevents androgen-dependent stabilization of the AR. Compared to flutamide, 2-hydroxy flutamide is a more potent antiandrogen in vivo, demonstrating a higher binding affinity for the AR (0.1% binding affinity relative to dihydrotestosterone) and, thus, is the predominant contributor to the therapeutic effects of flutamide in the treatment of prostate cancer.

Chemical Properties

HYDROXYFLUTAMIDE is Yellow-Brown Powder

Uses

HYDROXYFLUTAMIDE is used non-steroidal antagonist Flutamide. Shown to be an antianhydrogen.

Uses

The active metabolite of the widely used non-steroidal antagonist Flutamide (F598850). Shown to be an antianhydrogen.

Uses

Shown to be an antianhydrogen. The active metabolite of the widely used non-steroidal antagonist flutamide

Biochem/physiol Actions

Hydroxyflutamide plays a role in preventing the binding of 5α-dihydrotestosterone (DHT) and testosterone to the androgen receptors.

References

[1] kolvenbag g, furr b j a, blackledge g r p. receptor affinity and potency of non-steroidal antiandrogens: translation of preclinical findings into clinical activity[j]. prostate cancer and prostatic diseases, 1998, 1: 307-314.
[2] heinlein c a, chang c. androgen receptor in prostate cancer[j]. endocrine reviews, 2004, 25(2): 276-308.
[3] shet m s, mcphaul m, fisher c w, et al. metabolism of the antiandrogenic drug (flutamide) by human cyp1a2[j]. drug metabolism and disposition, 1997, 25(11): 1298-1303.
[4] gao w, kim j, dalton j t. pharmacokinetics and pharmacodynamics of nonsteroidal androgen receptor ligands[j]. pharmaceutical research, 2006, 23(8): 1641-1658.

HYDROXYFLUTAMIDE synthesis

Synthesis of HYDROXYFLUTAMIDE from 4-NITRO-3-(TRIFLUOROMETHYL)PHENOL

HYDROXYFLUTAMIDE Preparation Products And Raw materials

Raw materials

Propanamide, 2-methyl-2-[4-nitro-3-(trifluoromethyl)phenoxy]- 2-Methyl-2-(4-nitro-3-(trifluoroMethyl)phenoxy)propanoic Acid 4-NITRO-3-(TRIFLUOROMETHYL)PHENOL 4-Nitro-3-trifluoromethyl aniline Methyl 2-hydroxyisobutyrate

Preparation Products

HYDROXYFLUTAMIDE Suppliers

Global( 121)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	sales@capotchem.com	China	29797	60
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28180	58
career henan chemical co	+86-0371-86658258 15093356674;	factory@coreychem.com	China	29826	58
Hefei TNJ Chemical Industry Co.,Ltd.	0551-65418671	sales@tnjchem.com	China	34572	58
Dayang Chem (Hangzhou) Co.,Ltd.	571-88938639 +8617705817739	info@dycnchem.com	CHINA	52867	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
Zhengzhou Anhuida Chemical Co., Ltd	+8615903659408	admin@ahdchem.com	China	298	58
TargetMol Chemicals Inc.	+1-781-999-5354	support@targetmol.com	United States	19973	58
PT CHEM GROUP LIMITED	+86-85511178 +86-85511178	peter68@ptchemgroup.com	China	35453	58
ZHEJIANG JIUZHOU CHEM CO., LTD	+86-0576225566889 +86-13454675544	admin@jiuzhou-chem.com；jamie@jiuzhou-chem.com；alice@jiuzhou-chem.com	China	20000	58

Supplier	Advantage
Capot Chemical Co.,Ltd.	60
Hubei Jusheng Technology Co.,Ltd.	58
career henan chemical co	58
Hefei TNJ Chemical Industry Co.,Ltd.	58
Dayang Chem (Hangzhou) Co.,Ltd.	58
InvivoChem	58
Zhengzhou Anhuida Chemical Co., Ltd	58
TargetMol Chemicals Inc.	58
PT CHEM GROUP LIMITED	58
ZHEJIANG JIUZHOU CHEM CO., LTD	58

View Lastest Price from HYDROXYFLUTAMIDE manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2019-12-26	HYDROXYFLUTAMIDE 52806-53-8	US $0.10 / KG	1KG	95%-99%	1kg; 100kg	Career Henan Chemical Co

HYDROXYFLUTAMIDE
52806-53-8
US $0.10 / KG
95%-99%
Career Henan Chemical Co

52806-53-8(HYDROXYFLUTAMIDE)Related Search:

Flutamide Sildenafil 2-HYDROXY-2-METHYL-N-[4-NITRO-3-(TRIFLUOROMETHYL)PHENYL]PROPANAMIDE (2-HYDROXYFLUTAMIDE) HYDROXYFLUTAMIDE, [3H]- 2-(Trifluoromethyl)benzene-1,4-diamine

4-Nitro-3-trifluoromethyl aniline 2-Amino-5-acetamidobenzotrifluoride 2-METHYL-D3-N-(4-NITRO-3-TRIFLUOROMETHYLPHENYL)-2-TRIMETHYLSILYLOXY-PROPAMIDE-3,3,3-D3 HYDROXYFLUTAMIDE Hydroxy FlutaMide-d6

4-ACETAMIDO-2-METHYLNITROBENZENE 4'-NITRO-3'-(TRIFLUOROMETHYL)ACETANILIDE N-(4-AMINO-3-METHYLPHENYL)PROPANAMIDE

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2-hydroxy-2-methyl-n-(4-nitro-3-(trifluoromethyl)phenyl)-propanamid hydroxyniphtholide 2-Hydroxy-2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propionamide Hydroxy-Flutamide(Flutamide metabolite) 5-Hydroxyflutamide, 2-Hydroxy-2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]-propanamide, 5-HYDROXYFLUTAMIDE HYDROXYFLUTAMIDE (2-HYDROXY-2-METHYL-N-{4''-NITRO-3''-(TRIFLUOROMETHYL)PHENYL}PROPANAMIDE) α,α,α-Trifluoro-2-Methyl-4'-nitro-M- lactotoluidide HydroxyflutaMide (Hydroxyniphtholide) a,a,a-Trifluoro-2-methyl-4′-nitro-m-lactotoluidide Hydroxyflutamide, >=98% 2-Hydroxy-2-methyl-N-(3-trifluoromethyl-4-nitrophenyl)propanamide Hydroxyflutamid N-[3-(Trifluoromethyl)-4-nitrophenyl]-2-hydroxyisobutyramide Sch-16423 alpha,alpha,alpha-Trifluoro-2-methyl-4'-nitro-m-lactotoluidide Propanamide, 2-hydroxy-2-methyl-N-(4-nitro-3-(trifluoromethyl)phenyl)- HYDROXYFLUTAMIDE 2-HYDROXY-2-METHYL-N-[4-NITRO-3-(TRIFLUOROMETHYL)PHENYL]-PROPANAMIDE 2-HYDROXY-FLUTAMIDE CS-1970 2-Hydroxy-2-methyl-N-[4-nitro-3-(tr Hydroxy FL utamide Flutamide Hydroxy Impurity 2-Hydroxy-4'-nitro-3'-(trifluoromethyl)isobutyranilide Flutamide Impurity 7 2-Hydroxyflutamide (Hydroxyniphtholide) 2-Hydroxy-2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]prop Inhibitor,inhibit,prostate cancer,HFT,Flutamide,2 hydroxy Flutamide,2hydroxy Flutamide,Androgen Receptor,Hydroxyflutamide 52806-53-8 Amines Aromatics Intermediates & Fine Chemicals Metabolites & Impurities Pharmaceuticals Various Metabolites and Impurities Inhibitors Metabolites