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Dimenhydrinate

Anti-motion sickness Traits Effect Medicine interactions Precautions Adverse reactions Uses
Dimenhydrinate
Dimenhydrinate structure
CAS No.
523-87-5
Chemical Name:
Dimenhydrinate
Synonyms
emes;epha;DiMate;amosyt;dramyl;dromyl;emedyl;faston;gravol;vomexa
CBNumber:
CB4308768
Molecular Formula:
C17H21NO.C7H7ClN4O2
Formula Weight:
469.97
MOL File:
523-87-5.mol

Dimenhydrinate Properties

Melting point:
102-107°C
Density 
1.2586 (rough estimate)
refractive index 
1.6500 (estimate)
storage temp. 
Inert atmosphere,Room Temperature
solubility 
Slightly soluble in water, freely soluble in ethanol (96 per cent).
form 
neat
Water Solubility 
Slightly soluble (0.1-1 g/100 mL at 22 ºC)
InChIKey
NFLLKCVHYJRNRH-UHFFFAOYSA-N
CAS DataBase Reference
523-87-5(CAS DataBase Reference)
FDA 21 CFR
336.10
FDA UNII
JB937PER5C
EPA Substance Registry System
Dimenhydrinate (523-87-5)
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P301+P312+P330-P264-P270-P301+P312a-P330-P501a
Hazard Codes  Xn,Xi
Risk Statements  22-61-36/37/38
Safety Statements  22-26-36/37/39-53
WGK Germany  3
RTECS  XH5082000
TSCA  Yes
HS Code  2939590000

Dimenhydrinate price More Price(25)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich D2396 Dimenhydrinate 523-87-5 10g $57.8 2021-12-16 Buy
Sigma-Aldrich 1206006 Dimenhydrinate United States Pharmacopeia (USP) Reference Standard 523-87-5 200mg $366 2021-12-16 Buy
Sigma-Aldrich D2000000 Dimenhydrinate European Pharmacopoeia (EP) Reference Standard 523-87-5 $190 2021-12-16 Buy
Usbiological 010116 Dimenhydrinate 523-87-5 500mg $418 2021-12-16 Buy
TRC D460520 Dimenhydrinate 523-87-5 50g $140 2021-12-16 Buy

Dimenhydrinate Chemical Properties,Uses,Production

Anti-motion sickness

Dimenhydrinate is a complex salt of diphenhydramine and 8-chloro-theophylline. Antihistamine effect is weaker than diphenhydramine , and its anti-motion sickness and antiemetic effects are stronger. Mainly it is used to prevent and control nausea, vomiting, dizziness and Meniere's syndrome caused by motion sickness, .It is effective to treat a variety of dizziness, vomiting caused by radiation therapy, pregnancy, surgery, inner ear infections, and the use of drugs (such as streptomycin) .

Traits

Dimenhydrinate is transparent white crystalline powder, odorless, slightly soluble in water, soluble in ethanol.

Effect

As a complex salt of diphenhydramine and 8-chloro-theophylline,its role is the same as diphenhydramine hydrochloride, but its anti-histamine effect is weaker than the latter. It can inhibit medulla vomiting chemosensory area and it has a general central pivot inhibition effect and anticholinergic effects, which makes it have sedative and antiemetic effects.
It is quickly and completely absorbed after oral administration, it is effective after 15 to 60 minutes , the role is sustainable after 3-6 hours, the elimination phase half-life (t1/2β) is 4~6 hours, plasma protein binding rate is high. Mainly it is metabolized in the liver, it is excreted in urine in the form of metabolites . Patients with hepatic insufficiency using this service,because it can accumulate in the body , the dose should be reduced.
The above information is edited by the chemicalbook of Tian Ye.

Medicine interactions

1.It can not be taken with other CNS depressants and it cannot be taken after drinking.
2. It can be used to make ethanol, central nervous system depressants, tricyclic antidepressants more effective. It can momentarily affect barbiturates and sulfacetamide sodium absorption; if it is used with sodium aminosalicylate , plasma concentration of the latter is decreased.
3. Administration with food or milk can reduce the irritation of the stomach of the drug .

Precautions

1. The composition of the production and other ethanolamine allergies, newborns and premature infants are disabled.
2. It pregnant women in early pregnancy within four months use the drug, the incidence of congenital cardiovascular abnormalities and inguinal hernia of the fetus may be increased, the relationship with drug use has not been confirmed. Early pregnancy should not take this product.
3. The anti-emetic effect of the product can adds difficulty in diagnosing appendicitis and drug-induced reactions.
4. Lethargy , inability to concentrate etc.,can occur after treatment, ,patients should not drive cars, boats, etc., and it is not suitable to engage in the highly difficult and dangerous machine operation.

Adverse reactions

Low toxicity, high doses can cause drowsiness, and even cause a rash. Long-term use may cause blood diseases.

Uses

It is suitable for motion-sickness, pregnancy, radiation therapy , surgery etc. induced nausea , vomiting and dizziness.

Description

Dimenhydrinate (16.1.2) is a complex compound of N, N-dimethyl (2- diphenylmethoxy)ethylamine—diphenhydramine with 8-chlorotheophylline. While blocking the H1 receptor, dimenhydrinate simultaneously acts on the vomiting center.

Chemical Properties

White Solid

Originator

Dramamine,Searle,US,1949

Uses

Dimenhydrinate is used for preventing and stopping sea or airsickness, and for nausea and vomiting. Synonyms of this drug are dramamine, dadalon, emedyl, travelin, and others.

Uses

An antihistamine with antiemetic properties used to prevent nausea and motion sicknes composed of two drugs 8-Chlorotheophylline (C411440) and Diphenhydramine (D486900).

Uses

Used for treating vertigo, motion sickness, and nausea associated with pregnancy

Definition

ChEBI: The diphenhydramine salt of 8-chlorotheophylline. Its effects are similar to those of diphenhydramine, but it is less potent. It was thought that by combining the antiemetic effects of diphenhydramine with the mild stimulant effects of 8-chlorotheophyline, the extreme drowsiness induced by the former would be mitigated. However, the sedation caused by diphenhydramine is considerably stronger than the stimulation caused by 8-chlorotheophylline. Dimenhydrinate is used mainly as an antiemetic in the prevention nd treatment of motion sickness.

Manufacturing Process

58.8 grams of 8-chlorotheophylline and 70 grams of β-dimethylaminoethyl benzohydryl ether are dissolved in 150 cc of hot methanol. Then 5 grams of activated charcoal are added and the mixture is boiled for an hour. It is filtered hot and the filtrate cooled. The crystalline precipitate of βdimethylaminoethyl benzohydryl ether 8-chlorotheophyllinate is collected on a filter, washed with ether and dried. It melts at 96-99°C. It is dissolved in boiling ethyl acetate, filtered hot to remove any insoluble material, and then chilled. The salt so obtained melts at 102.5°-104°C after filtration, washing with ether and drying.

brand name

Dommanate (Forest).

Therapeutic Function

Antinauseant

General Description

The 8-chlorotheophyllinate (theoclate) salt of diphenhydramine, 8-chlorotheophylline 2-(diphenylmethoxy)-N,N-dimethylethylamine (Dramamine), is a white crystalline, odorless powder that is highly soluble in water and freely soluble in alcohol and chloroform. Dimenhydrinate is recommended for nausea of motion sickness and for hyperemesis gravidarum (nausea of pregnancy).

General Description

Crystalline white powder.

Air & Water Reactions

Slightly soluble in water. Slightly acidic.

Health Hazard

SYMPTOMS: Symptoms associated with Dimenhydrinate include: drowsiness, lethargy, fatigue hypnosis and coma. Initial sedation may be followed by central nervous system hyperexcitability. Also, the victim may experience dry mouth, anorexia, nausea, vomiting, abdominal distress, constipation, and/or diarrhea.

Fire Hazard

Flash point data for Dimenhydrinate are not available but Dimenhydrinate is probably non-flammable.

Safety Profile

Poison by intraperitoneal and intravenous routes. Moderately toxic by ingestion. A drug much used for motion sickness. Human systemic effects by ingestion: arrhythmias, convulsions, distorted perceptions, hallucinations, intracranial pressure increase. Mutation data reported. When heated to decomposition it emits very toxic fumes of NOx, and Cl-. See also AMINES.

Veterinary Drugs and Treatments

In veterinary medicine, dimenhydrinate is used primarily for its antiemetic effects for vomiting and in the prophylactic treatment of motion sickness in dogs and cats. Dimenhydrinate may be useful as an adjunctive treatment for feline pancreatitis. As dimenhydrinate is often thought of as “half-strength diphenhydramine” it can be employed whenever a histmine-1 blocker is desired.

Dimenhydrinate Preparation Products And Raw materials

Raw materials

Preparation Products


Dimenhydrinate Suppliers

Global( 190)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com China 22607 55
Shenzhen Nexconn Pharmatechs Ltd
15013857715
admin@nexconn.com CHINA 3004 58
Hubei Jusheng Technology Co.,Ltd.
86-18871470254
027-59599243 linda@hubeijusheng.com CHINA 28229 58
hdzhl biotechnology co., ltd
86-13032617415
sales@luchibiology.com CHINA 1275 58
Xiamen AmoyChem Co., Ltd
+86 592-605 1114
sales@amoychem.com CHINA 6369 58
HubeiwidelychemicaltechnologyCo.,Ltd
18627774460
faith@widelychemical.com CHINA 743 58
BOC Sciences
1-631-485-4226
1-631-614-7828 inquiry@bocsci.com United States 19752 58
Shanghai Longyu Biotechnology Co., Ltd.
+8615821988213
+86 15821988213 info@longyupharma.com China 2514 58
CONIER CHEM AND PHARMA LIMITED
86-18523575427
sales@conier.com China 47498 58
career henan chemical co
15093356674 0371-55982848
0086-371-86658258 factory@coreychem.com CHINA 29863 58

View Lastest Price from Dimenhydrinate manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2022-01-21 Dimenhydrinate
523-87-5
US $0.00 / KG 100g 98%+ 100kg WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD
2021-12-10 Dimenhydrinate
523-87-5
US $10.00 / KG 1KG 99 500kg/month Handan Tongyi New Material Technology Co., Ltd
2021-11-09 Dimenhydrinate
523-87-5
US $0.00 / Kg/Bag 2Kg/Bag USP 20 tons Sinoway Industrial co., ltd.

Dimenhydrinate Spectrum


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