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(Z)-Guggulsterone

CAS No.
39025-23-5
Chemical Name:
(Z)-Guggulsterone
Synonyms
GUGGULSTERONE;GUGULSTERONE;GUGGULSTERONE Z;Z-Gugglesterone;GUGGULESTERONE Z;(Z)-Guggulsterone;CIS GUGGULSTERONE;GUGGULSTERONE Z(P);GUGGULSTERONE (Z FORM);Guggulsterone Z (25 mg)
CBNumber:
CB4309068
Molecular Formula:
C21H28O2
Molecular Weight:
312.45
MDL Number:
MFCD01310757
MOL File:
39025-23-5.mol
MSDS File:
SDS
Last updated:2023-06-30 15:45:59

(Z)-Guggulsterone Properties

Melting point 188-190°
alpha D26 -61° (c = 1 in chloroform)
Boiling point 463.3±45.0 °C(Predicted)
Density 1.10±0.1 g/cm3(Predicted)
storage temp. 2-8°C
solubility DMSO: 5 mg/mL
form powder
color light yellow
Stability Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
InChIKey WDXRGPWQVHZTQJ-OSJVMJFVSA-N
LogP 3.650 (est)
EWG's Food Scores 1
FDA UNII 6CST3U34GN

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H335
Precautionary statements  P261-P271-P304+P340+P312-P403+P233-P405-P501
Hazard Codes  Xi
Risk Statements  37-38
Safety Statements  36
WGK Germany  3
HS Code  2914299000
NFPA 704
0
1 0

(Z)-Guggulsterone price More Price(25)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 1302214 Guggulsterone Z United States Pharmacopeia (USP) Reference Standard 39025-23-5 25mg $489 2024-03-01 Buy
Sigma-Aldrich 78251 (Z)-Guggulsterone analytical standard 39025-23-5 10mg $283 2022-05-15 Buy
Cayman Chemical 71800 (Z)-Guggulsterone 39025-23-5 5mg $109 2024-03-01 Buy
Cayman Chemical 71800 (Z)-Guggulsterone 39025-23-5 50mg $849 2024-03-01 Buy
Sigma-Aldrich G5168 (Z)-Guggulsterone ≥89% (HPLC), powder 39025-23-5 5mg $208 2024-03-01 Buy
Product number Packaging Price Buy
1302214 25mg $489 Buy
78251 10mg $283 Buy
71800 5mg $109 Buy
71800 50mg $849 Buy
G5168 5mg $208 Buy

(Z)-Guggulsterone Chemical Properties,Uses,Production

Description

Guggulsterone-(Z) (39025-23-5) is a natural steroid from?Commiphora mukul?extract (guggulipid) which lowers cholesterol and acts as an FXR antagonist.1?Attenuates astrocyte-mediated neuroinflammation.2? Induces differentiation of pluripotent stem cells to dopaminergic neurons.3 Produces antidepressant-like effects via activation of the BDNF signaling pathway in mouse models.4

Uses

(Z)-Guggulsterone acts as an α-glucosidase inhibitor also known as a hypolipidemic agent.

Uses

Z-Guggulsterone acts as an α-glucosidase inhibitor also known as a hypolipidemic agent.

Definition

ChEBI: Guggulsterone is a 3-hydroxy steroid. It has a role as an androgen.

Biological Activity

Broad spectrum steroid receptor ligand; mineralocorticoid, progesterone and glucocorticoid receptor antagonist (K i values are 37, 224 and 252 nM respectively) and weak androgen receptor agonist (K i = 315 nM). Induces apoptosis in prostate cancer cells and inhibits angiogenesis via suppression of the VEGF-VEGFR2-Akt signalling pathway. Exhibits antilipidemic activity via antagonism of the farnesoid X receptor (FXR) and displays antiseptic, antirheumatic and anti-inflammatory activity in vivo . More active isomer of Guggulsterone (Pregna-4,17(20)-diene-3,16-dione ).

Biochem/physiol Actions

(Z)-Guggulsterone is a natural product that lowers cholesterol due to its function as an antagonist ligand for the bile acid receptor. (Z)-Guggulsterone is a nuclear hormone receptor that regulates the transcription of several genes involved in cholesterol metabolism and plays a role in cholesterol level regulation. (Z)-Guggulsterone is also a selective farnesoid X receptor (FXR) modulator.

storage

Store at RT

References

1) Urizar?et al.?(2002),?A Natural Product That Lowers Cholesterol as an Antagonist Ligand for FXR; Science,?296?1703 2) Liu?et al.?(2018),?Z-Guggulsterone attenuates astrocytes-mediated neuroinflammation after ischemia by inhibiting toll-like receptor 4 pathway; J. Neurochem.,?147?803 3) Agbay?et al.?(2018),?Guggulsterone-releasing Microspheres Direct the Differentiation of Human Induced Pluripotent Stem Cells Into Neural Phenotypes; Biomed. Mater.,?13?034104 4) Liu?et al.?(2017),?Z-Guggulsterone Produces Antidepressant-Like Effects in Mice through Activation of the BDNF Signaling Pathway; Int. J. Neuropsychopharmacol.,?20?485

(Z)-Guggulsterone Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 130)Suppliers
Supplier Tel Email Country ProdList Advantage
Shanghai Zheyan Biotech Co., Ltd.
18017610038 zheyansh@163.com CHINA 3620 58
career henan chemical co
+86-0371-86658258 sales@coreychem.com China 29914 58
Biochempartner
0086-13720134139 candy@biochempartner.com CHINA 967 58
Chengdu Biopurify Phytochemicals Ltd.
+8618080483897 sales@biopurify.com China 3424 58
Hubei Jusheng Technology Co.,Ltd.
18871490254 linda@hubeijusheng.com CHINA 28180 58
Shaanxi Pioneer Biotech Co., Ltd .
+8613259417953 sales@pioneerbiotech.com China 3000 58
BOC Sciences
+1-631-485-4226 inquiry@bocsci.com United States 19553 58
Chongqing Chemdad Co., Ltd
+86-023-61398051 +8613650506873 sales@chemdad.com China 39916 58
SIMAGCHEM CORP
+86-13806087780 sale@simagchem.com China 17368 58
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 19892 58

View Lastest Price from (Z)-Guggulsterone manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
(Z)-Guggulsterone pictures 2024-03-28 (Z)-Guggulsterone
39025-23-5
US $0.00 / MG 20MG 99% HPLC 100KG Changsha Staherb Natural Ingredients Co., Ltd.
(Z)-Guggulsterone pictures 2024-03-25 (Z)-Guggulsterone
39025-23-5
US $0.00 / kg 1kg 98% 200kg Shanghai Joiny Pharmaceutical Co.,LTD
(E)-Guggulsterone pictures 2019-07-06 (E)-Guggulsterone
39025-23-5
US $1.00 / KG 1g 99% 100KG Career Henan Chemical Co
  • (Z)-Guggulsterone pictures
  • (Z)-Guggulsterone
    39025-23-5
  • US $0.00 / MG
  • 99% HPLC
  • Changsha Staherb Natural Ingredients Co., Ltd.

(Z)-Guggulsterone Spectrum

4,17(20)-(CIS)-PREGNADIEN-3,16-DIONE GUGULSTERONE GUGGULESTERONE Z GUGGULSTERONE Z GUGGULSTERONE (Z FORM) CIS-4,17(20)-PREGNADIENE-3,16-DIONE CIS GUGGULSTERONE PREGNA-4,17(20)-DIENE-3,16-DIONE (17Z)-Pregna-4,17(20)-diene-3,16-dione (Z)-Guggulsterone (17Z)-Pregna-4,17(20)-diene-3,16-dione, 4,17(20)-cis-Pregnadiene-3,16-dione Z-Gugglesterone GUGGULSTERONE Z(P) (Z)-Pregna-4,17(20)-diene-3,16-dione Guggulsterone Z (25 mg) Pregna-4,17(20)-diene-3,16-dione, (17Z)- Z-Guggulsterone Z-Guggulsterone HPLC≥90% 39025-23-5 5mg GUGGULSTERONE (8R,9S,10R,13S,14S,Z)-17-ethylidene-10,13-dimethyl-7,8,9,10,11,12,13,14,15,17-decahydro-1H-cyclopenta[a]phenanthrene-3,16(2H,6H)-dione 39025-23-5 Analytical Chromatography Product Catalog Alphabetic Analytical Standards