JNJ 63533054
- CAS No.
- 1802326-66-4
- Chemical Name:
- JNJ 63533054
- Synonyms
- CS-2223;JNJ 63533054;JNJ-63533054 (JNJ63533054;JNJ-63533054 >=98% (HPLC);(S)-3-Chloro-N-(2-oxo-2-((1-phenylethyl)amino)ethyl)benzamide;3-Chloro-N-[2-oxo-2-[[(1S)-1-phenylethyl]amino]ethyl]benzamide;Benzamide, 3-chloro-N-[2-oxo-2-[[(1S)-1-phenylethyl]amino]ethyl]-;L-tryptophan,blood-brain,oral,CNS,L-phenylalanine,G Protein-Coupled Receptor 139,barrier,JNJ63533054,Inhibitor,GPR139,JNJ-63533054,inhibit
- CBNumber:
- CB43110757
- Molecular Formula:
- C17H17ClN2O2
- Molecular Weight:
- 316.78
- MDL Number:
- MFCD29924732
- MOL File:
- 1802326-66-4.mol
- MSDS File:
- SDS
| Boiling point | 559.7±45.0 °C(Predicted) |
|---|---|
| Density | 1.224±0.06 g/cm3(Predicted) |
| storage temp. | room temp |
| solubility | Soluble in DMSO (up to 35 mg/ml). |
| pka | 12.77±0.46(Predicted) |
| form | powder |
| color | white to beige |
| optical activity | [α]/D -89 to -99°, c = 1 in ethanol |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 2 months. |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319 | |||||||||
| Precautionary statements | P264-P270-P280-P301+P312-P302+P352-P305+P351+P338 | |||||||||
| NFPA 704 |
|
JNJ 63533054 price More Price(18)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML1624 | JNJ-63533054 ≥98% (HPLC) | 1802326-66-4 | 5MG | $105 | 2023-06-20 | Buy |
| Sigma-Aldrich | SML1624 | JNJ-63533054 ≥98% (HPLC) | 1802326-66-4 | 25MG | $424 | 2023-06-20 | Buy |
| Cayman Chemical | 23450 | JNJ-63533054 ≥98% | 1802326-66-4 | 1mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 23450 | JNJ-63533054 ≥98% | 1802326-66-4 | 5mg | $93 | 2024-03-01 | Buy |
| Cayman Chemical | 23450 | JNJ-63533054 ≥98% | 1802326-66-4 | 10mg | $169 | 2024-03-01 | Buy |
JNJ 63533054 Chemical Properties,Uses,Production
Description
JNJ-63533054 (1802326-66-4) is a potent and selective brain-penetrant GPR139 agonist (EC50=16 nM) an orphan G-protein-coupled receptor expressed in the CNS.1?Tritium-labeled JNJ-63533054 binds to cell membranes expressing GPR139 and can be displaced by putative endogenous ligands.2?Decreases compulsive-like alcohol drinking and hyperalgesia in alcohol-dependent rodents.3?Suppresses morphine intake in a mouse self-administration model.4
Uses
JNJ 63533054 is a potent and selective agonist of hGPR139 with an EC50 = 16 nM.
Biochem/physiol Actions
JNJ-63533054 is a potent and selective agonist of the orphan receptor hGPR139, a GPCR receptor expressed in the brain in circumventricular regions of the habenula and septum. JNJ-63533054 has an EC50 value of 16 nM, crosses the blood-brain barrier, and is orally available.
storage
Store at RT
References
1) Dvorak?et al.?(2015),?Identification and SAR of Glycine Benzamides as Potent Agonists for the GPR139 Receptor;?ACS Med. Chem. Lett.,?6?1015 2) Liu?et al. (2015),?GPR139, an Orphan Receptor Highly Enriched in the Habenula and Septum, Is Activated by the Essential Amino Acids L-Tryptophan and L-Phenylalanine; Mol. Pharmacol.,?88?911 3) Kononoff?et al.?(2018),?Systemic and Intra-Habenular Activation of the Orphan G Protein-Coupled Receptor GPR139 Decreases Compulsive-Like Alcohol Drinking and Hyperalgesia in Alcohol-Dependent Rats;?eNeuro,?5?ENEURO 0153-18 2018 4) Wang?et al.?(2019),?Genetic behavioral screen identifies an orphan anti-opioid system; Science,?365?1267
JNJ 63533054 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| SHANGHAI T&W PHARMACEUTICAL CO., LTD. | +86-021-61551413 +8618813727289 | contact@trustwe.com | China | 5738 | 58 |
| Tianjin Xinshengjiahe Science & Technology Development Co,.Ltd | +86-86-22-87899925 +86-8618522618860 | 18522618860@163.com | China | 694 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
View Lastest Price from JNJ 63533054 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-12-24 | JNJ 63533054
1802326-66-4
|
US $1.00 / g | 1g | 99% | 20kg | Career Henan Chemical Co |
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- JNJ 63533054
1802326-66-4
- US $1.00 / g
- 99%
- Career Henan Chemical Co
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