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ChemicalBook >> CAS DataBase List >>8-(2-amino-3-chloro-5-(1-methyl-1H-indazol-5-yl)pyridin-4-yl)-2,8-diazaspiro[4.5]decan-1-one

8-(2-amino-3-chloro-5-(1-methyl-1H-indazol-5-yl)pyridin-4-yl)-2,8-diazaspiro[4.5]decan-1-one

8-(2-amino-3-chloro-5-(1-methyl-1H-indazol-5-yl)pyridin-4-yl)-2,8-diazaspiro[4.5]decan-1-one Structure
8-(2-amino-3-chloro-5-(1-methyl-1H-indazol-5-yl)pyridin-4-yl)-2,8-diazaspiro[4.5]decan-1-one structure
CAS No.
1607837-31-9
Chemical Name:
8-(2-amino-3-chloro-5-(1-methyl-1H-indazol-5-yl)pyridin-4-yl)-2,8-diazaspiro[4.5]decan-1-one
Synonyms
CCT-251921;LM-3860,CCT251921;CCT-251921;CCT 251921;CCT-251921,Cyclin dependent kinase,Inhibitor,CDK,CCT251921,CCT 251921,inhibit;8-[2-amino-3-chloro-5-(1-methylindazol-5-yl)pyridin-4-yl]-2,8-diazaspiro[4.5]decan-1-one;8-[2-amino-3-chloro-5-(1-methyl-1H-indazol-5-yl)-4-pyridinyl]-2,8-Diazaspiro[4.5]decan-1-one;8-(2-amino-3-chloro-5-(1-methyl-1H-indazol-5-yl)pyridin-4-yl)-2,8-diazaspiro[4.5]decan-1-one;2,8-Diazaspiro[4.5]decan-1-one, 8-[2-amino-3-chloro-5-(1-methyl-1H-indazol-5-yl)-4-pyridinyl]-
CBNumber:
CB43133466
Molecular Formula:
C21H23ClN6O
Molecular Weight:
410.9
MDL Number:
MFCD30502895
MOL File:
1607837-31-9.mol
Last updated:2023-07-12 17:07:48
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8-(2-amino-3-chloro-5-(1-methyl-1H-indazol-5-yl)pyridin-4-yl)-2,8-diazaspiro[4.5]decan-1-one Properties

Boiling point 696.4±55.0 °C(Predicted)
Density 1.51±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO : ≥ 28 mg/mL (68.14 mM)
pka 15.81±0.20(Predicted)

8-(2-amino-3-chloro-5-(1-methyl-1H-indazol-5-yl)pyridin-4-yl)-2,8-diazaspiro[4.5]decan-1-one price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ChemScene CS-5521 CCT-251921 99.77% 1607837-31-9 1mg $108 2021-12-16 Buy
ChemScene CS-5521 CCT-251921 99.77% 1607837-31-9 10mg $420 2021-12-16 Buy
ChemScene CS-5521 CCT-251921 99.77% 1607837-31-9 25mg $840 2021-12-16 Buy
ChemScene CS-5521 CCT-251921 99.77% 1607837-31-9 50mg $1140 2021-12-16 Buy
Crysdot CD00008621 CCT251921 97% 1607837-31-9 50mg $1496 2021-12-16 Buy
Product number Packaging Price Buy
CS-5521 1mg $108 Buy
CS-5521 10mg $420 Buy
CS-5521 25mg $840 Buy
CS-5521 50mg $1140 Buy
CD00008621 50mg $1496 Buy

8-(2-amino-3-chloro-5-(1-methyl-1H-indazol-5-yl)pyridin-4-yl)-2,8-diazaspiro[4.5]decan-1-one Chemical Properties,Uses,Production

Description

CCT251921 is a potent, selective, and orally bioavailable small-molecule modulators of the mediator complex-associated kinases CDK8 and CDK19. (IC50 data: CDK8:=2.3 nM; CDK19 = 2.6 nM). CCT251921 showed the optimal compromise of in vitro biochemical, pharmacokinetic, and physicochemical properties and is suitable for progression to animal models of cancer. The Mediator complex-associated cyclin-dependent kinase CDK8 has been implicated in human disease, particularly in colorectal cancer where it has been reported as a putative oncogene.

8-(2-amino-3-chloro-5-(1-methyl-1H-indazol-5-yl)pyridin-4-yl)-2,8-diazaspiro[4.5]decan-1-one Preparation Products And Raw materials

Raw materials

Preparation Products

8-(2-amino-3-chloro-5-(1-methyl-1H-indazol-5-yl)pyridin-4-yl)-2,8-diazaspiro[4.5]decan-1-one Suppliers

Global( 34)Suppliers
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TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 19892 58
Career Henan Chemica Co 		+86-0371-86658258 15093356674; laboratory@coreychem.com China 30255 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		86-571-88216897,88216896 13588875226 sales@hzclap.com CHINA 6313 58
Hangzhou MolCore BioPharmatech Co.,Ltd. 		+86-057181025280; +8617767106207 sales@molcore.com China 49739 58
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Aladdin Scientific 		+1-833-552-7181 sales@aladdinsci.com United States 52927 58
Amadis Chemical Company Limited 		571-89925085 sales@amadischem.com China 131981 58
MedChemexpress LLC 021-58955995 sales@medchemexpress.cn United States 4863 58
ShangHai Caerulum Pharma Discovery Co., Ltd. 18149758185 sales-cpd@caerulumpharma.com China 3421 58
Zhongshan Geometric Biological Technology Co., Ltd. +86-13168912896 China 253 58
Supplier Advantage
TargetMol Chemicals Inc. 		58
Career Henan Chemica Co 		58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		58
Hangzhou MolCore BioPharmatech Co.,Ltd. 		58
Jilin Chinese Academy of Sciences-yanshen Technology 		58
Aladdin Scientific 		58
Amadis Chemical Company Limited 		58
MedChemexpress LLC 58
ShangHai Caerulum Pharma Discovery Co., Ltd. 58
Zhongshan Geometric Biological Technology Co., Ltd. 58
8-(2-amino-3-chloro-5-(1-methyl-1H-indazol-5-yl)pyridin-4-yl)-2,8-diazaspiro[4.5]decan-1-one CCT-251921 LM-3860,CCT251921 8-[2-amino-3-chloro-5-(1-methyl-1H-indazol-5-yl)-4-pyridinyl]-2,8-Diazaspiro[4.5]decan-1-one CCT-251921;CCT 251921 8-[2-amino-3-chloro-5-(1-methylindazol-5-yl)pyridin-4-yl]-2,8-diazaspiro[4.5]decan-1-one 2,8-Diazaspiro[4.5]decan-1-one, 8-[2-amino-3-chloro-5-(1-methyl-1H-indazol-5-yl)-4-pyridinyl]- CCT-251921,Cyclin dependent kinase,Inhibitor,CDK,CCT251921,CCT 251921,inhibit 1607837-31-9