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A23187

A23187
A23187 structure
CAS No.
52665-69-7
Chemical Name:
A23187
Synonyms
A23187;CALCIMYCIN;Calimycin ;IONOPHORE A-23187;CALCIMYCIN A23187;ANTIBIOTIC A23187;A 23187, CaliMycin;Calcimycin hydrate;CALCIMYCIN HYDRATE;A23187 (CalciMycin)
CBNumber:
CB4315720
Molecular Formula:
C29H37N3O6
Formula Weight:
523.62
MOL File:
52665-69-7.mol

A23187 Properties

Melting point:
187-190 °C
alpha 
D25 -56° (c = 1 in chloroform)
Boiling point:
710.3±55.0 °C(Predicted)
Density 
1.28±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
Soluble in DMSO with warming or sonication. Also soluble in ethanol or ethyl acetate
pka
pKa1 6.9 in 90% DMSO
form 
Solid
color 
white to light yellow
Merck 
13,1639
BRN 
1096801
FDA UNII
37H9VM9WZL
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS07
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P280a-P304+P340-P305+P351+P338-P405-P501a
Hazard Codes  Xi,Xn
Risk Statements  36/37/38-20/21/22
Safety Statements  26-36
WGK Germany  3
RTECS  DM4676000
8
HS Code  29349990
Toxicity LD50 i.p. in mice: 10 mg/kg (Gale)

A23187 price More Price(17)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 100105 A23187, Free Acid, 52665-69-7 1mg $42.36 2021-03-22 Buy
Sigma-Aldrich 21186 Calcium ionophore III Selectophore?, function tested 5 mg $109 2021-03-22 Buy
Sigma-Aldrich 100105 A23187, Free Acid, 52665-69-7 5mg $109.15 2021-03-22 Buy
Sigma-Aldrich 21186 Calcium ionophore III Selectophore?, function tested 25 mg $753 2021-03-22 Buy
Alfa Aesar J63020 Antibiotic A23187, 98% 52665-69-7 10mg $216 2021-03-22 Buy

A23187 Chemical Properties,Uses,Production

Chemical Properties

white to off-white solid

Uses

Calcimycin is a potent calcium ionophore isolated from Streptomyces chartreusis in 1974. Calcimycin is a spiroketal substituted by pyrollic and benzoxazolyl groups which afford its high affinity and selectivity for calcium. Calimycin exhibits broad biological activity against bacteria, fungi and protozoa. It has found wide application as a research tool for calcium-regulated cellular events.

Biological Activity

Calcium ionophore that induces Ca 2+ -dependent cell death by increasing intracellular calcium concentration. Promotes intracelllular ROS generation and platelet particle formation (fragmentation) in vitro and in vivo .

Purification Methods

It recrystallises from Me2CO as colourless needles. Protect it from light and moisture, store in a refrigerator. It is soluble in Me2SO or EtOH and can be stored for 3 months without loss of activity. The Mg and Ca salts are soluble in organic solvents and cross biological membranes. It has a pKa of 6.9 in 90% Me2SO. The Ca complex crystallises from 50% EtOH as colourless prisms. It is highly TOXIC. [Pressman Ann Rev Biochem 45 501 1976, Chaney et al. J Am Chem Soc 96 1932 1974, Chaney et al. J Antibiotics 29 124 1976, Suzuki et al. Anal Biochem 61 382 1989, Simon & Carafoli Methods Enzymol 56 439 1977.]

A23187 Preparation Products And Raw materials

Raw materials

Preparation Products


A23187 Suppliers

Global( 98)Suppliers
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BOC Sciences
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