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Anifostine trihydrate

CAS No.
112901-68-5
Chemical Name:
Anifostine trihydrate
Synonyms
Amifostine;AMIFOSTIN;S-(2-((3-Aminopropyl)amino)ethyl) O,O-dihydrogen phosphorothioate trihydrate;WR2721;ANIFOSTINE;Ethyol trihydrate;Amifostine (150 mg);Amifostine (1019406);Anifostine trihydrate;Amphotericin trihydrate
CBNumber:
CB4316378
Molecular Formula:
C5H17N2O4PS
Molecular Weight:
232.23
MDL Number:
MFCD00233058
MOL File:
112901-68-5.mol
Last updated:2023-10-13 18:16:27

Anifostine trihydrate Properties

storage temp. 2-8°C
solubility PBS (pH 7.2): 5 mg/ml
form powder
pka pKa1 <2.0; pKa2 4.2; pKa3 9.0; pKa4 11.7(at 25℃)
InChIKey JKOQGQFVAUAYPM-UHFFFAOYSA-N
CAS DataBase Reference 112901-68-5(CAS DataBase Reference)
FDA UNII M487QF2F4V

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P301+P312+P330
Hazard Codes  Xn
Risk Statements  22
Safety Statements  26-36
WGK Germany  3
RTECS  TE6491000
HS Code  2930909165
NFPA 704
0
2 0

Anifostine trihydrate price More Price(26)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich PHR2940 Amifostine pharmaceutical secondary standard, certified reference material 112901-68-5 300MG $287 2024-03-01 Buy
Sigma-Aldrich A5922 Amifostine trihydrate ≥97% (TLC), powder 112901-68-5 100mg $660 2024-03-01 Buy
Sigma-Aldrich 1019406 Amifostine trihydrate United States Pharmacopeia (USP) Reference Standard 112901-68-5 150mg $644 2024-03-01 Buy
Cayman Chemical 14398 Amifostine (hydrate) ≥95% 112901-68-5 50mg $62 2024-03-01 Buy
Cayman Chemical 14398 Amifostine (hydrate) ≥95% 112901-68-5 100mg $109 2024-03-01 Buy
Product number Packaging Price Buy
PHR2940 300MG $287 Buy
A5922 100mg $660 Buy
1019406 150mg $644 Buy
14398 50mg $62 Buy
14398 100mg $109 Buy

Anifostine trihydrate Chemical Properties,Uses,Production

Description

Amifostine is a broad-spectrum cytoprotective agent, once used as a military anti-radiation agent, and now used as a protective drug for radiotherapy and chemotherapy. It has significantly effective in reducing the side effects of anticancer drugs such as cyclophosphamide, ciplatin, doxorubicin, and anti-HIV drugs such as 3-azido-3-deoxythymidine, without affecting the efficacy of anticancer or anti-HIV drugs curative effect. At present, the commercially available amifostine products include freeze-dried powder injection(ETHYOL )produced by American Life Sciences Co., Ltd. It is only available as a lyophilized powder for injection, but is thermally unstable.

Uses

Amifostine may provide renal protection during PRRT using somatostatin analogs by mitigating radiation damage and reducing the absorbed kidney radiation dose. Amifostine remediates the degenerative effects of radiation on the mineralization capacity of the murine mandible.

Uses

Protectant (topical); radioprotector.

brand name

Ethyol (MedImmune) [USAN previously used: Ethiofos.].

Biochem/physiol Actions

Radioprotective agent. Selectively protects normal tissues from the damaging effects of anti-neoplastic radiation therapy. Selectivity is due to preferential uptake by normal tissues and subsequent metabolic activation to 2-(3-aminopropyl)aminoethanethiol.

Synthesis

1). In the 50L stainless steel reactor, add 13.6kg of pure water, 19.2mol (7.6kg) of sodium thiophosphate dodecahydrate, add N-(2-bromoethyl)-1,3-propanediamine bisulfite under stirring Hydrobromide salt 19.8mol (6.8kg, 3% excess), 11.0kg DMSO was added slowly while maintaining the reaction temperature not to exceed 25°C. After the dropwise addition of DMSO, the reaction solution was monitored with silver nitrate solution until no black precipitate was precipitated, and the reaction was completed. Centrifugal filtration to obtain 6.1 kg of crude amifostine trihydrate.2). In the 50L stainless steel crystallization kettle, add 22.0kg of pure water, add 6.1kg of the crude 3-aminopropylamine ethyl thiophosphoric acid prepared in the previous step, dissolve at room temperature, add 95.0g of activated carbon, and stir at room temperature for 15 minutes , filter, add methanol 8.7kg to the mother liquor, cool down to 0 ℃ through cooling water, maintain 18 hours, centrifugal filter, obtain 4.8kg of 3-aminopropylamine ethyl thiophosphoric acid without crystal water once recrystallization.3). Add 20.0kg of pure water to the 50L stainless steel crystallization kettle, add 4.8kg of 3-aminopropylamine ethyl thiophosphoric acid without crystal water obtained by the first recrystallization, stir and dissolve at room temperature, add 75.0g of activated carbon , stirred at room temperature for 15 minutes, filtered, added 3.2kg of ethanol to the mother liquor, cooled to 0°C through cooling water, maintained for 18 hours, centrifugally filtered, and vacuum dried at 30°C to obtain 3.6kg of amifostine trihydrate.

Anifostine trihydrate Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 261)Suppliers
Supplier Tel Email Country ProdList Advantage
Hebei Mojin Biotechnology Co., Ltd
+8613288715578 sales@hbmojin.com China 12452 58
Henan Bao Enluo International TradeCo.,LTD
+86-17331933971 +86-17331933971 deasea125996@gmail.com China 2504 58
Shanghai Daken Advanced Materials Co.,Ltd
+86-371-66670886 info@dakenam.com China 14764 58
career henan chemical co
+86-0371-86658258 sales@coreychem.com China 29914 58
Jinan Chenghui-Shuangda Chemical Co.,Ltd
+86-531-58897082 ericqiao@jnchsd.com CHINA 158 58
Hubei xin bonus chemical co. LTD
86-13657291602 linda@hubeijusheng.com CHINA 22968 58
Shandong chuangyingchemical Co., Ltd.
18853181302 sale@chuangyingchem.com CHINA 5909 58
BOC Sciences
+1-631-485-4226 inquiry@bocsci.com United States 19553 58
Shanghai Longyu Biotechnology Co., Ltd.
+8615821988213 info@longyupharma.com China 2530 58
Chongqing Chemdad Co., Ltd
+86-023-61398051 +8613650506873 sales@chemdad.com China 39916 58

View Lastest Price from Anifostine trihydrate manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Anifostine trihydrate pictures 2023-10-14 Anifostine trihydrate
112901-68-5
US $0.00 / KG 1KG 99% 50000KG/month Hebei Mojin Biotechnology Co., Ltd
Anifostine trihydrate pictures 2023-09-14 Anifostine trihydrate
112901-68-5
US $0.00-0.00 / kg 1kg 99% 20 tons Wuhan Han Sheng New Material Technology Co.,Ltd
Anifostine trihydrate pictures 2023-09-06 Anifostine trihydrate
112901-68-5
US $0.00-0.00 / KG 1KG 99% 500000kg Hebei Guanlang Biotechnology Co., Ltd.

Anifostine trihydrate Spectrum

Amifostine (150 mg) Anifostine trihydrate Ethanethiol,2-[(3-aMinopropyl)aMino]-, 1-(dihydrogen phosphate), hydrate (1:3) Amifostine trihydrate, >=98% Aminopropylamino)ethylsulfanylphosphonic acid trihydrate S-2-(3-AMINOPROPYLAMINO)ETHYL O,O-DIHYDROGEN PHOSPHOROTHIOATE WR2721 Amifostinetrihydrateormonohydrate Ethanethiol, 2-((3-aminopropyl)amino)-, dihydrogen phosphate (ester), trihydrate Amifostine Disulfide (25 mg) 2-(3-aminopropylamino)ethylsulfanylphosphonic acid trihydrate AMINOPROPYL AMINOETHYLTHIOPHOSPHATE Ethyol trihydrate Aminopropylamino)ethylsulfanylphosphonic acid trihydrate USP/EP/BP ANIFOSTINE 2-(3-Aminopropylamino)ethylsulfanylphosphonic acid trihydrate USP/EP/BP Amifostine trihydrate (WR2721) Amifostine (1019406) Amifostine Disulfide (1019417) Amifostine AMIFOSTIN S-(2-((3-Aminopropyl)amino)ethyl) O,O-dihydrogen phosphorothioate trihydrate DNA-damage,thiol,HIF-PH,cytoprotective,Broad-spectrum,Hypoxia-inducible factors,HIF-α1,WR-2721,MDM-2/p53,Inhibitor,p53,Amifostine trihydrate,WR 2721,inhibit,antiangiogenic,radioprotector,HIF/HIF Prolyl-Hydroxylase,HIFs 2-(3-Amino-propylamino)ethylthiophosphonic acid,trihydrate Amphotericin trihydrate 112901-68-5 1129-68-5 C5H15N2O3PS3H2O C5H21N2O6PS Cancer Research Antitumor Agents BioChemical Therapy Adjuncts Inhibitors 112901-68-5