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GDC-0077

GDC-0077 structure

CAS No.: 2060571-02-8

Chemical Name:: GDC-0077

Synonyms: CPD1573;RG 6114;GDC-0077;RO 7113755;Inavolisib;GDC-0077 Inavolisib;Inavolisib (GDC-0077);GDC-0077; RG 6114; RO 7113755;Inavolisib (Synonyms: GDC-0077;Apoptosis,RG 6114,RG-6114,Phosphoinositide 3-kinase,Inhibitor,PI3K,Inavolisib,GDC 0077,GDC0077,inhibit

CBNumber:: CB43175543

Molecular Formula:: C18H19F2N5O4

Molecular Weight:: 407.37

MDL Number:

MOL File:: 2060571-02-8.mol

Last updated:2024-04-24 09:22:13

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GDC-0077 Properties

Boiling point	698.0±65.0 °C(Predicted)
Density	1.63±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMSO:110.0(Max Conc. mg/mL);245.47(Max Conc. mM)
pka	15.89±0.50(Predicted)
form	Solid
color	Off-white to yellow
InChIKey	SGEUNORSOZVTOL-CABZTGNLSA-N
SMILES	C(N)(=O)[C@@H](NC1C=C2OCCN3C=C(N4[C@H](C(F)F)COC4=O)N=C3C2=CC=1)C
FDA UNII	L4C1UY2NYH

GDC-0077 price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
American Custom Chemicals Corporation	PRK0000448	(S)-2-((2-((S)-4-(DIFLUOROMETHYL)-2-OXOOXAZOLIDIN-3-YL)-5,6-DIHYDROBENZO[F]IMIDAZO[1,2-D][1,4]OXAZEPIN-9-YL)AMINO)PROPANAMIDE 95.00%	2060571-02-8	5MG	$451.72	2021-12-16	Buy
ChemScene	CS-6459	GDC-0077 98.94%	2060571-02-8	5mg	$540	2021-12-16	Buy
ChemScene	CS-6459	GDC-0077 98.94%	2060571-02-8	10mg	$900	2021-12-16	Buy
ChemScene	CS-6459	GDC-0077 98.94%	2060571-02-8	25mg	$1260	2021-12-16	Buy
ChemScene	CS-6459	GDC-0077 98.94%	2060571-02-8	50mg	$2020	2021-12-16	Buy

Product number	Packaging	Price	Buy
PRK0000448	5MG	$451.72	Buy
CS-6459	5mg	$540	Buy
CS-6459	10mg	$900	Buy
CS-6459	25mg	$1260	Buy
CS-6459	50mg	$2020	Buy

GDC-0077 Chemical Properties,Uses,Production

Description

Inavolisib, or GDC-0077, is a potent and selective PI3K inhibitor. GDC-0077 blocks an enzyme involved in cancer growth called PI3K. GDC0077 binds to and inhibits various members of the PI3K family, including activating mutations in the catalytic alpha isoform PIK3CA. PI3K inhibition prevents the activation of the PI3K-mediated signaling pathway and inhibits the growth and survival of PI3K-overexpressing tumor cells. The IUPAC name of this compound is (S)-2-((2-((S)-4-(difluoromethyl)-2-oxooxazolidin-3-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)amino)propanamide.

in vitro

GDC-0077 (RG6114) is >300-fold more selective for PI3Kα over the other class I PI3K isoforms (β, δ, and γ) and >2000-fold more selective over PIK family members. GDC-0077 selectively degrades mutant PI3Kα in a proteasome-dependent fashion, resulting in a reduction of PI3K pathway activity biomarkers such as pAKT and pPRAS40, inhibition of cell proliferation, and increased apoptosis in human PIK3CA-mutant breast cancer cell lines to a greater extent when compared to PIK3CA wild-type cells.

GDC-0077 Preparation Products And Raw materials

Raw materials

Preparation Products

GDC-0077 Suppliers

Global( 60)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Nantong HI-FUTURE Biology Co., Ltd.	+undefined18051384581	sales@chemhifuture.com	China	3136	58
Hubei Chuchang Biotech Co., Ltd.	+86-18727130788 +86-18727130788	info@chuchangbiotech.com	China	100	58
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
Neostar United (Changzhou) Industrial Co., Ltd.	+86-519-519-85557386	marketing1@neostarunited.com	China	8349	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Career Henan Chemica Co	+86-0371-86658258 15093356674;	laboratory@coreychem.com	China	30255	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10523	58
Wuhan Topule Biopharmaceutical Co., Ltd	+8618327326525	masar@topule.com	China	8474	58
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	57511	58

Supplier	Advantage
Nantong HI-FUTURE Biology Co., Ltd.	58
Hubei Chuchang Biotech Co., Ltd.	58
ATK CHEMICAL COMPANY LIMITED	60
BOC Sciences	58
Neostar United (Changzhou) Industrial Co., Ltd.	58
TargetMol Chemicals Inc.	58
Career Henan Chemica Co	58
Zhejiang J&C Biological Technology Co.,Limited	58
Wuhan Topule Biopharmaceutical Co., Ltd	58
Aladdin Scientific	58

View Lastest Price from GDC-0077 manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2024-04-19	Inavolisib (Synonyms: GDC-0077; RG6114) 2060571-02-8	US $0.00-0.00 / mg	5mg	98%+ HPLC HNMR	20g	Hubei Chuchang Biotech Co., Ltd.

Inavolisib (Synonyms: GDC-0077; RG6114)
2060571-02-8
US $0.00-0.00 / mg
98%+ HPLC HNMR
Hubei Chuchang Biotech Co., Ltd.

GDC-0077 Spectrum

GDC-0077(2060571-02-8)¹HNMR

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GDC-0077 Inavolisib Propanamide, 2-[[2-[(4S)-4-(difluoromethyl)-2-oxo-3-oxazolidinyl]-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepin-9-yl]amino]-, (2S)- (2S)-2-[[2-[(4S)-4-(difluoromethyl)-2-oxo-1,3-oxazolidin-3-yl]-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepin-9-yl]amino]propanamide GDC-0077; RG 6114; RO 7113755 RO 7113755 RG 6114 CPD1573 Inavolisib (GDC-0077) GDC-0077 Inavolisib Apoptosis,RG 6114,RG-6114,Phosphoinositide 3-kinase,Inhibitor,PI3K,Inavolisib,GDC 0077,GDC0077,inhibit (S)-2-[[2-[(S)-4-(Difluoromethyl)-2-oxo-3-oxazolidinyl]-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl]amino]propanamide Inavolisib (Synonyms: GDC-0077 2060571-02-8