6-Gingerol
- CAS No.
- 23513-14-6
- Chemical Name:
- 6-Gingerol
- Synonyms
- GINGEROL;Gingerols;rac-(R*)-5-Hydroxy-1-(4-hydroxy-3-methoxyphenyl)decane-3-one;6-GINGEROL;GINGEROL [6];(s)-3-decanon;6-Gingerol ,98%;6-Gingerol std.;[6]-Gingerol>(s)-(6)-gingerol
- CBNumber:
- CB4328683
- Molecular Formula:
- C17H26O4
- Molecular Weight:
- 294.39
- MDL Number:
- MFCD00210507
- MOL File:
- 23513-14-6.mol
- MSDS File:
- SDS
| Melting point | 31℃ |
|---|---|
| Boiling point | 453.0±35.0 °C(Predicted) |
| Density | 1.083±0.06 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | methanol: soluble1mg/mL, clear, colorless |
| form | Pale yellow oil |
| pka | 10.02±0.20(Predicted) |
| color | White to Light yellow |
| InChI | InChI=1S/C17H26O4/c1-3-4-5-6-14(18)12-15(19)9-7-13-8-10-16(20)17(11-13)21-2/h8,10-11,14,18,20H,3-7,9,12H2,1-2H3/t14-/m0/s1 |
| InChIKey | NLDDIKRKFXEWBK-AWEZNQCLSA-N |
| SMILES | C(C1=CC=C(O)C(OC)=C1)CC(=O)C[C@@H](O)CCCCC |
| LogP | 2.485 (est) |
| CAS DataBase Reference | 23513-14-6(CAS DataBase Reference) |
| FDA UNII | 925QK2Z900 |
| NIST Chemistry Reference | Gingerol(23513-14-6) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22-36/37/38 | |||||||||
| Safety Statements | 26-36/37 | |||||||||
| RIDADR | UN 2811 6.1 / PGIII | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | HE0757000 | |||||||||
| HS Code | 29145090 | |||||||||
| NFPA 704 |
|
6-Gingerol price More Price(48)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 50866 | [6]-Gingerol analytical standard | 23513-14-6 | 10mg | $614 | 2024-03-01 | Buy |
| Sigma-Aldrich | 345868 | [6]-Gingerol | 23513-14-6 | 5mg | $225 | 2024-03-01 | Buy |
| Cayman Chemical | 11707 | 6-Gingerol ≥98% | 23513-14-6 | 1mg | $49 | 2024-03-01 | Buy |
| Cayman Chemical | 11707 | 6-Gingerol ≥98% | 23513-14-6 | 5mg | $120 | 2024-03-01 | Buy |
| Sigma-Aldrich | G1046 | [6]-Gingerol ≥98% (HPLC) | 23513-14-6 | 5mg | $268 | 2024-03-01 | Buy |
6-Gingerol Chemical Properties,Uses,Production
Chemical Properties
Light yellow ceraceous solid
Uses
[6]-Gingerol has been used:
- to study its effects on transient receptor potential (TRP) channels
- to study its effects on experimental models of non-alcoholic steatohepatitis
- to determine its effects on microsomal prostaglandine E2 synthase 1 (mPGES-1), glycogen synthase kinase 3β (GSK-3β) and β-catenin pathway in A549 cell line
- to analyse the effects of 6-Shogaol (6-SG) on diabetic nephropathy (DN) in db/db mice
Definition
ChEBI:Gingerol is a beta-hydroxy ketone that is 5-hydroxydecan-3-one substituted by a 4-hydroxy-3-methoxyphenyl moiety at position 1; believed to inhibit adipogenesis. It is a constituent of fresh ginger. It has a role as an antineoplastic agent and a plant metabolite. It is a beta-hydroxy ketone and a member of guaiacols.
General Description
6-Gingerol is a naturally occurring plant phenoland an active pungent constituent found in the rhizome of ginger, which is known to possess anti-inflammatory, anti-tumor and antioxidant properties and can hence, serve as a potential candidate in the treatment of cancer.
Biological Activity
6-Gingerol is the major pharmacologically-active component of ginger. It is known to exhibit a variety of biological activities including anticancer, anti-inflammation, and anti-oxidation. 6-Gingerol has been found to possess anticancer activities via its effect on a variety of biological pathways involved in apoptosis, cell cycle regulation, cytotoxic activity, and inhibition of angiogenesis.
Biochem/physiol Actions
Bioactive compound found in ginger (Zingiber officinale) with antioxidant activity, which functions as an anti-inflammatory and antitumor agent. [6]-Gingerol down regulates proinflammatory cytokine release by macrophages. It has been shown to inhibit COX-2 expression by blocking the activation of p38 MAP kinase and NF-κB in phorbol ester-stimulated mouse skin.
Anticancer Research
6-Gingerol is a plant polyphenol and an active constituent of Zingiber officinale, whichshowed antioxidant, anti-inflammation, and antitumor properties. It has the capacityto inhibit NOS, TNF-α, and COX-2 enzymes which are regulated by NF-κB(Aggarwal and Shishodia 2004; Wang et al. 2012). It hinders the cell growth ofprostate, gastric, and breast cancer cells and suppresses the lung metastasis ofB16F10 melanoma. It exhibits antitumorigenic effect in human colorectal cancercells via upregulating NSAID-activated gene-1 (NAG-1) (Aggarwal et al. 2008). Italters ERK1/2/JNK/AP1 pathway and induces apoptosis in colon cancer cells in acaspase-dependent manner (Singh et al. 2016b). ROS levels were significantlyincreased in K562 and MOLT4 cells treated with gingerol, and apoptosis wasinduced in leukemia cells by mitochondrial pathway (Wang et al. 2012).
6-Gingerol Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Changsha Staherb Natural Ingredients Co., Ltd. | +86-0731-84213302 +8618374838656 | sales@staherb.cn | China | 1025 | 58 |
| Hebei Zhuanglai Chemical Trading Co.,Ltd | +8613343047651 | admin@zlchemi.com | China | 476 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21691 | 55 |
| Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | fandachem@gmail.com | China | 9348 | 55 |
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3620 | 58 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Chengdu GLP biotechnology Co Ltd | 028-87075086 13350802083 | scglp@glp-china.com | CHINA | 1824 | 58 |
| Chengdu Biopurify Phytochemicals Ltd. | +8618080483897 | sales@biopurify.com | China | 3424 | 58 |
| Nanjing Dolon Biotechnology Co.,Ltd. | 18905173768 | sales@dolonchem.com | CHINA | 2972 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
View Lastest Price from 6-Gingerol manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-04-24 | 6-Gingerol
23513-14-6
|
US $120.00 / kg | 1kg | 99% | 20ton | Hebei Zhuanglai Chemical Trading Co.,Ltd | |
 |
2024-04-23 | gingerol
23513-14-6
|
US $0.00-0.00 / kg | 1kg | 1-40% | 1000kg | Changsha Staherb Natural Ingredients Co., Ltd. | |
 |
2024-04-23 | 6-Gingerol
23513-14-6
|
US $0.00 / KG | 1KG | ≥98% HPLC | 1000KG | Changsha Staherb Natural Ingredients Co., Ltd. |
-
- 6-Gingerol
23513-14-6
- US $120.00 / kg
- 99%
- Hebei Zhuanglai Chemical Trading Co.,Ltd
-
- gingerol
23513-14-6
- US $0.00-0.00 / kg
- 1-40%
- Changsha Staherb Natural Ingredients Co., Ltd.
-
- 6-Gingerol
23513-14-6
- US $0.00 / KG
- ≥98% HPLC
- Changsha Staherb Natural Ingredients Co., Ltd.
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