A971432
- CAS No.
- 1240308-45-5
- Chemical Name:
- A971432
- Synonyms
- A971432;A971432,A 971432;A-971432 >=95% (HPLC);1-(4-((3,4-dichlorobenzyl)oxy)benzyl)azetidine-3-carboxylic acid;1-[[4-[(3,4-Dichlorophenyl)methoxy]phenyl]methyl]-3-azetidinecarboxylic acid;1-({4-[(3,4-dichlorophenyl)methoxy]phenyl}methyl)azetidine-3-carboxylic acid;3-Azetidinecarboxylic acid, 1-[[4-[(3,4-dichlorophenyl)methoxy]phenyl]methyl]-
- CBNumber:
- CB43303041
- Molecular Formula:
- C18H17Cl2NO3
- Molecular Weight:
- 366.24
- MDL Number:
- MFCD30182357
- MOL File:
- 1240308-45-5.mol
- MSDS File:
- SDS
| Boiling point | 520.0±50.0 °C(Predicted) |
|---|---|
| Density | 1.402±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | Slightly soluble in chloroform |
| form | powder |
| pka | 2.70±0.20(Predicted) |
| color | white to beige |
| FDA UNII | 3QLJ2AZ8GW |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319 | |||||||||
| Precautionary statements | P305+P351+P338 | |||||||||
| NFPA 704 |
|
A971432 price More Price(10)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML1744 | A-971432 ≥95% (HPLC) | 1240308-45-5 | 5mg | $114 | 2024-03-01 | Buy |
| Sigma-Aldrich | SML1744 | A-971432 ≥95% (HPLC) | 1240308-45-5 | 25mg | $464 | 2024-03-01 | Buy |
| Cayman Chemical | 25326 | A-971432 ≥98% | 1240308-45-5 | 1mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 25326 | A-971432 ≥98% | 1240308-45-5 | 5mg | $93 | 2024-03-01 | Buy |
| Cayman Chemical | 25326 | A-971432 ≥98% | 1240308-45-5 | 10mg | $169 | 2024-03-01 | Buy |
A971432 Chemical Properties,Uses,Production
Uses
A 971432 is used in the preparation of benzylazetidinecarboxylate derivatives as agonists and antagonists of the S1P5 receptor.
Biochem/physiol Actions
A-971432 is an orally bioavailable, non-clastogenic, azetidinecarboxylate compound that acts as a highly potent and selective sphingosine-1-phosphate receptor 5 agonist (IC50?= 6 nM/S1P5, 362 nM/S1P1 and >10 μM/S1P3 in a radio-ligand binding assay) without affect the activity of 129 protein kinases (IC50?>10 μM). A-971432 is shown to enhance blood-brain barrier integrity and reverse lipid accumulation and age-related cognitive decline in mice in vivo with good pharmacokinetics (t1/2??= 5.7 h; Cmax?= 2,500 ng/ml; AUC = 35,000 ng.h/ml at 10 mg/kg, p.o. in CD1 mice). Likewise, oral gavage showed good plasma exposure and no sign of lymphopenia in rats (10, 30, and 100 mg/kg.
storage
Store at RT
A971432 Preparation Products And Raw materials
Raw materials
Preparation Products
A971432 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Guangzhou Isun Pharmaceutical Co., Ltd | 020-39119399 18927568969 | isunpharm@qq.com | China | 4428 | 55 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
| Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 | sales@glpbio.cn | China | 6870 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing1@energy-chemical.com | China | 44894 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24131 | 58 |
| Suzhou Zhixin Biotechnology Co., Ltd. | 0512-65118909 15162312715 | sales@szzxbio.com | China | 2976 | 58 |
| Nantong QuanYi Biotechnology Co., Ltd | 0513-66337626 18051384581 | sales@chemhifuture.com | China | 3977 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 8740 | 58 |