GNE140
- CAS No.
- 2003234-63-5
- Chemical Name:
- GNE140
- Synonyms
- GNE140;CS-2624;(R)-GNE-140;(R)-GNE-140 (GNE-140;GNE-140;GNE 140;GNE140;Inhibitor,LDH,(R) GNE 140,inhibit,Lactate Dehydrogenase,(R)GNE140;(R)-3-((2-chlorophenyl)thio)-4-hydroxy-6-(4-morpholinophenyl)-6-(thiophen-3-yl)-5,6-dihydropyridin-2(1H)-one;2(1H)-Pyridinone, 3-[(2-chlorophenyl)thio]-5,6-dihydro-4-hydroxy-6-[4-(4-morpholinyl)phenyl]-6-(3-thienyl)-, (6R)-
- CBNumber:
- CB43353026
- Molecular Formula:
- C25H23ClN2O3S2
- Molecular Weight:
- 499.04
- MDL Number:
- MOL File:
- 2003234-63-5.mol
| Boiling point | 695.4±55.0 °C(Predicted) |
|---|---|
| Density | 1.46±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C(protect from light) |
| solubility | DMSO:14.4(Max Conc. mg/mL);28.9(Max Conc. mM) |
| pka | 4.50±1.00(Predicted) |
| InChIKey | SUFXXEIVBZJOAP-RUZDIDTESA-N |
| SMILES | C1(=O)N[C@](C2=CC=C(N3CCOCC3)C=C2)(C2C=CSC=2)CC(O)=C1SC1=CC=CC=C1Cl |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
GNE140 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML2580 | GNE-140 ≥98% (HPLC) | 2003234-63-5 | 5MG | $160 | 2024-03-01 | Buy |
| Sigma-Aldrich | SML2580 | GNE-140 ≥98% (HPLC) | 2003234-63-5 | 25MG | $617 | 2024-03-01 | Buy |
| Biorbyt Ltd | orb611623 | (R)-GNE-140 | 2003234-63-5 | 100mg | $912.9 | 2021-12-16 | Buy |
| ChemScene | CS-7646 | (R)-GNE-140 99.20% | 2003234-63-5 | 10mg | $370 | 2021-12-16 | Buy |
| ChemScene | CS-7646 | (R)-GNE-140 99.20% | 2003234-63-5 | 50mg | $1100 | 2021-12-16 | Buy |
GNE140 Chemical Properties,Uses,Production
Description
GNE140 ((R)-GNE-140) is a potent lactate dehydrogenase A (LDHA) inhibitor, with IC50s of 3 nM and 5 nM for LDHA and LDHB, respectively; (R)-GNE-140 is 18-fold more potent than S enantiomer.
Biochem/physiol Actions
GNE-140 is an active site-targeting, potent and selective lactate dehydrogenase (LDH) inhibitor (LDH-A/B/C IC50 = 3/5/5 nM; LDH-A IC50 = 22 nM with mixed GNE-140 diastereomers; malate dehydrogenases MDH1/2 IC50 >10 μM; 301 kinases IC50 >1 μM) that reduces cellular lactate (IC50 = 670 nM; MIA PaCa-2) and upregulates pyruvate levels. GNE-140 affects glycolysis-dependent cancer proliferation (IC50 = 430 nM; MIA PaCa-2 & KP-2) & survival, but not oxidative phosphorylation (OXPHOS)-dependent growth. Due to rapid clearance, GNE-140 is ineffective against MIA PaCa-2 tumor growth with only transient lactate-reducing efficacy in tumor tissue in mice in vivo (100-400 mg/kg b.i.d. p.o.).
GNE140 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd | +86-18341751992 +86-15382112998 | 757984502@qq.com | China | 892 | 58 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| Shanghai Gubang New Materail Technology Co. LTD | 21-51317962 +8618721305404 | 16728589@qq.com | CHINA | 272 | 58 |
| Shenzhen Shengda Pharma Limited | 755-85269922 +8613424394241 | sales@shengdapharm.com | CHINA | 310 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8474 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +undefined18621343501 | product@acmec-e.com | China | 33349 | 58 |