Naphazoline nitrate
- CAS No.
- 5144-52-5
- Chemical Name:
- Naphazoline nitrate
- Synonyms
- rinazin;Privina;naftizin;NaphazoL;naphtyzin;naphthisen;naphthizen;ine nitrate;privinenitrate;NAPHAZOLINI NITRAS
- CBNumber:
- CB4336127
- Molecular Formula:
- C14H15N3O3
- Molecular Weight:
- 273.29
- MDL Number:
- MFCD00014316
- MOL File:
- 5144-52-5.mol
- MSDS File:
- SDS
| Melting point | 167-170 °C |
|---|---|
| storage temp. | 2-8°C |
| solubility | Sparingly soluble in water, soluble in ethanol (96 per cent). |
| form | Solid |
| color | White to off-white |
| Sensitive | Hygroscopic |
| BRN | 3779329 |
| InChIKey | ZAHXYMFVNNUHCP-UHFFFAOYSA-N |
| CAS DataBase Reference | 5144-52-5(CAS DataBase Reference) |
| FDA UNII | SC99GR1T5S |
| UNSPSC Code | 41116107 |
| NACRES | NA.24 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P301+P312+P330 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22 | |||||||||
| Safety Statements | 22-36/37-60-36 | |||||||||
| RIDADR | 3249 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | NJ4376000 | |||||||||
| F | 3-10 | |||||||||
| HazardClass | 6.1(b) | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29332900 | |||||||||
| NFPA 704 |
|
Naphazoline nitrate price More Price(9)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | N0100000 | Naphazoline nitrate European Pharmacopoeia (EP) Reference Standard | 5144-52-5 | n0100000 | $220 | 2024-03-01 | Buy |
| Alfa Aesar | L12617 | 2-(1-Naphthylmethyl)-2-imidazoline nitrate, 99% | 5144-52-5 | 25g | $35.2 | 2021-12-16 | Buy |
| Alfa Aesar | L12617 | 2-(1-Naphthylmethyl)-2-imidazoline nitrate, 99% | 5144-52-5 | 100g | $103 | 2021-12-16 | Buy |
| TRC | N343955 | Naphazoline nitrate | 5144-52-5 | 100g | $205 | 2021-12-16 | Buy |
| Usbiological | 285510 | Naphazoline nitrate | 5144-52-5 | 50g | $220 | 2021-12-16 | Buy |
Naphazoline nitrate Chemical Properties,Uses,Production
Chemical Properties
White or almost white, crystalline powder.
Uses
antihistamine
Definition
ChEBI: Naphazoline nitrate is a member of naphthalenes.
Indications
Naphazoline hydrochloride and naphazoline nitrate are white or almost white crystalline powders soluble 1 in 6 and 1 in 36 water, respectively. These are potent sympathomimetic vasoconstrictors with a direct alpha-adrenergic receptor stimulatory action, and may be used as topical decongestants in 0.05% or 0.1% eyedrops. Frequent application of these solutions will produce a reactive hyperaemia. Instillation should not be repeated in less than 4-6 hours to avoid this rebound congestion.
Naphazoline eyedrops cause slight mydriasis and are contra-indicated in patients with actual or suspected closed-angle glaucoma.
Although not administered systemically, topical application of naphazoline has resulted in systemic absorption, and it is readily absorbed from the gastro-intestinal tract (Martindale, 1977).
in vivo
Naphazoline nitrate (0.2 mg/kg, 10 μl per eye; IP, once) reduces histamine or antigen-induced conjunctival vascular hyperpermeability in mice, and reduces conjunctivitis in mice via effects on inflammation, NGF and VEGF[1].
| Animal Model: | Female wild-type BALB/c mice (4-5 weeks, 18 ± 2 g, n=8/group, allergic conjunctivitis mouse model established using histamine or an antigen (ovalbumin))[1] |
| Dosage: | 0.2 mg/mL, 10 μl per eye |
| Administration: | Intraperitoneal injection (IP), once |
| Result: | Significantly suppressed conjunctival dye leakage in mice with histamine or antigen?induced conjunctival vascular hyperpermeability. Reduced inflammatory reactions and the levels of IL-1β, IL-6, IFN-γ, and IL-4. Reduced the levels of IgE, GMCSF, NGF and VEGF in antigen-induced conjunctival vascular hyperpermeability mice. |
IC 50
IL-1β; IL-6; IL-4
Naphazoline nitrate Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 22866 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +86-15531157085; +8615531157085 | abby@chuanghaibio.com | China | 8805 | 58 |
| Hebei Mujin Biotechnology Co.,Ltd | +86 13288715578 +8613288715578 | sales@hbmojin.com | China | 12776 | 58 |
| Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 | sales1@chuanghaibio.com | China | 5471 | 58 |
| Hebei Fengjia New Material Co., Ltd | +86-0311-87836622 +86-18712993135 | sales01@tairunfaz.com | China | 8051 | 58 |
| Henan Bao Enluo International TradeCo.，LTD | +86-17331933971 +86-17331933971 | deasea125996@gmail.com | China | 2472 | 58 |
| Hangzhou ICH Biofarm Co., Ltd | +86-0571-28186870; +undefined8613073685410 | sales@ichemie.com | China | 1015 | 58 |
| Nanjing Gold Pharmaceutical Technology Co. Ltd. | 025-84209270 15906146951 | CHINA | 115 | 55 | |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29856 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28172 | 58 |
View Lastest Price from Naphazoline nitrate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-05-31 | Naphazoline nitrate
5144-52-5
|
0.99 | RongNa Biotechnology Co.,Ltd | ||||
 |
2025-05-30 | Naphazoline nitrate
5144-52-5
|
US $10.00 / KG | 1KG | 99% | 10 mt | Hebei Chuanghai Biotechnology Co., Ltd | |
 |
2025-05-29 | Naphazoline nitrate
5144-52-5
|
US $0.00-0.00 / Kg/Drum | 1KG | 99%-101% By Titrimetry; BP | 500kg | WUHAN FORTUNA CHEMICAL CO., LTD |
-
- Naphazoline nitrate
5144-52-5
- 0.99
- RongNa Biotechnology Co.,Ltd
-
- Naphazoline nitrate
5144-52-5
- US $10.00 / KG
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
-
- Naphazoline nitrate
5144-52-5
- US $0.00-0.00 / Kg/Drum
- 99%-101% By Titrimetry; BP
- WUHAN FORTUNA CHEMICAL CO., LTD