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ChemicalBook >> CAS DataBase List >>4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-1,2-oxazol-3-yl]-2-methylbenzoic acid

4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-1,2-oxazol-3-yl]-2-methylbenzoic acid

4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-1,2-oxazol-3-yl]-2-methylbenzoic acid Structure
4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-1,2-oxazol-3-yl]-2-methylbenzoic acid structure
CAS No.
864725-62-2
Chemical Name:
4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-1,2-oxazol-3-yl]-2-methylbenzoic acid
Synonyms
4-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2-methylbenzoic acid;Fluralaner-024;Fluralaner Impurity 3;Fluralaner Impurity 2;Fluralaner Impurity 6;Fluralaner N-1 intermediate;Intermediate of FluralanerⅢ;Chemical Formula: C18H12Cl2F3NO3 Molecular Weight: 418.19;4-[5-(3,5-Dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-3-isoxazolyl]-2-methylbenzoic Acid;Benzoic acid, 4-[5-(3,5-dichlorophenyl)-4,5-dihydro-5-(trifluoromethyl)-3-isoxazolyl]-2-methyl-
CBNumber:
CB43364743
Molecular Formula:
C18H12Cl2F3NO3
Molecular Weight:
418.19
MDL Number:
MOL File:
864725-62-2.mol
MSDS File:
SDS
Last updated:2023-12-14 16:38:12
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4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-1,2-oxazol-3-yl]-2-methylbenzoic acid Properties

Boiling point 511.3±60.0 °C(Predicted)
Density 1.49±0.1 g/cm3(Predicted)
storage temp. 2-8°C Refrigerator
pka 3.61±0.25(Predicted)

4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-1,2-oxazol-3-yl]-2-methylbenzoic acid Chemical Properties,Uses,Production

Uses

4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-1,2-oxazol-3-yl]-2-methylbenzoic acid is an organic intermediate compound used in the synthesis of Fluralaner.

Synthesis

4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-1,2-oxazol-3-yl]-2-methylbenzoic acid is prepared by the reaction of 2-methyl-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-benzoic acid and 3-bromo-5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazole. The steps are as follows:
In a 100 mL three-necked flask, under nitrogen protection, add 3-bromo-5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazole (700 mg, 1.93 mmoL), 2-methyl-4-(4,4,5,5-tetramethyl-1,3-dioxaborolan-2-yl)benzoic acid (560 mg, 2.14 mmoL), potassium acetate (379 mg, 3.86mmol), 1,4-dioxane (15mL), water (1.5mL) and Pd(dppf)Cl2 (141mg, 0.19mmol), incubate the reaction at 85±5 for 8h, stop heating to room temperature, then Water (50 mL) was added to quench and then extracted with dichloromethane (45 mL×2), the organic phases were combined, the organic phase was washed once with saturated brine (50 mL), and then the organic phase was washed with anhydrous sodium sulfate (10.0 g). ) was dried for 2 h, the organic phase was concentrated to dryness under reduced pressure, and the concentrated residue was purified by silica gel column chromatography (developing solvent: n-heptane/ethyl acetate=10:1-3:1) to obtain 4-(5-(3 ,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2-methylbenzoic acid (694 mg, 86%) as a pale yellow solid.
4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-1,2-oxazol-3-yl]-2-methylbenzoic acid synthesis

4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-1,2-oxazol-3-yl]-2-methylbenzoic acid Preparation Products And Raw materials

Raw materials

Preparation Products

4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-1,2-oxazol-3-yl]-2-methylbenzoic acid Suppliers

Global( 75)Suppliers
Supplier Tel Email Country ProdList Advantage
Hebei Xinsheng New Material Technology Co., LTD. 		+86-16632316109 xinshengkeji@xsmaterial.com China 1100 58
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21691 55
Hainan Mike Biomedical Technology Co., Ltd 		+86-15120707353 +86-18876637353 tunanmedicine@hotemail.com China 43 58
ChemExpress 		+86-021-58950125 info@chemexpress.com China 555 58
Nanjing Doge Biomedical Technology Co., Ltd 		+86-25-58227606 +86-15305155328 sales@dogechemical.com China 4128 58
Changsha Junyu Chemexpress.co., Ltd 		+86-13723890100 info@csjyyy.cn China 134 58
PNP Biotech Co. Ltd 		+8618516098983 sales@pnpbiotech.com China 1001 58
ZHEJIANG JIUZHOU CHEM CO., LTD 		+86-0576225566889 +86-13454675544 admin@jiuzhou-chem.com；jamie@jiuzhou-chem.com；alice@jiuzhou-chem.com China 20000 58
Jiangsu Guotai Guomian Trading Co. Ltd. 		+86-512-58916079 +86-13601562190 pharmachem@gtgmt.com China 148 58
China National Standard Pharmaceutical Corporation Limited 		+8615391658522 overseasales@yongstandards.com China 11927 58
Supplier Advantage
Hebei Xinsheng New Material Technology Co., LTD. 		58
Henan Tianfu Chemical Co.,Ltd. 		55
Hainan Mike Biomedical Technology Co., Ltd 		58
ChemExpress 		58
Nanjing Doge Biomedical Technology Co., Ltd 		58
Changsha Junyu Chemexpress.co., Ltd 		58
PNP Biotech Co. Ltd 		58
ZHEJIANG JIUZHOU CHEM CO., LTD 		58
Jiangsu Guotai Guomian Trading Co. Ltd. 		58
China National Standard Pharmaceutical Corporation Limited 		58

View Lastest Price from 4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-1,2-oxazol-3-yl]-2-methylbenzoic acid manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
4-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2-methylbenzoic acid pictures 2024-03-28 4-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2-methylbenzoic acid
864725-62-2
 US $0.00 / kg 25kg 98% Inquiry PNP Biotech Co. Ltd
4-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2-methylbenzoic acid pictures 2023-10-14 4-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2-methylbenzoic acid
864725-62-2
 US $0.00-0.00 / Kg 1Kg 99.9% 30000 KG Hebei Xinsheng New Material Technology Co., LTD.
4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-1,2-oxazol-3-yl]-2-methylbenzoic acid pictures 2022-10-01 4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-1,2-oxazol-3-yl]-2-methylbenzoic acid
864725-62-2
 US $0.00-0.00 / kg 1kg 98% 1Ton Henan Aochuang Chemical Co.,Ltd.

864725-62-2(4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-1,2-oxazol-3-yl]-2-methylbenzoic acid)Related Search:

1,3-dichloro-5-(3,3,3-trifluoroprop-1-en-2-yl)benzene 2-AMino-N-(2,2,2-trifluoroethyl)acetaMide hydrochloride Fluralaner Impurity 5 3-(4-bromo-3-methylphenyl)-5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazole Fluralaner Impurity 4
Fluralaner 3',5'-DICHLORO-2,2,2-TRIFLUOROACETOPHENONE

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4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-1,2-oxazol-3-yl]-2-methylbenzoic acid Fluralaner Impurity 2 Fluralaner Impurity 3 Fluralaner-024 Fluralaner Impurity 6 4-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2-methylbenzoic acid Fluralaner N-1 intermediate Benzoic acid, 4-[5-(3,5-dichlorophenyl)-4,5-dihydro-5-(trifluoromethyl)-3-isoxazolyl]-2-methyl- 4-[5-(3,5-Dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-3-isoxazolyl]-2-methylbenzoic Acid Chemical Formula: C18H12Cl2F3NO3 Molecular Weight: 418.19 Intermediate of FluralanerⅢ 864725-62-2 API