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Piperonyl butoxide

Piperonyl butoxide
Piperonyl butoxide structure
Chemical Name:
Piperonyl butoxide
Molecular Formula:
Formula Weight:
MOL File:

Piperonyl butoxide Properties

Melting point:
<25 °C
Boiling point:
180 °C
1.059 g/mL at 25 °C(lit.)
vapor pressure 
0.02 hPa (60 °C)
refractive index 
n20/D 1.498(lit.)
Flash point:
>230 °F
storage temp. 
water: slightly soluble0.0289g/L at 20.4°C
Specific Gravity
1.060 (20/4℃)
Clear yellow
Water Solubility 
<0.1 g/100 mL at 18 ºC
Stable. Combustible. Incompatible with oxidizing agents.
CAS DataBase Reference
51-03-6(CAS DataBase Reference)
Indirect Additives used in Food Contact Substances
EWG's Food Scores
NIST Chemistry Reference
Piperonyl butoxide(51-03-6)
3 (Vol. 30, Sup 7) 1987
EPA Substance Registry System
Piperonyl butoxide (51-03-6)
  • Risk and Safety Statements
Signal word  Warning
Hazard statements  H310-H401-H411-H410
Precautionary statements  P273-P501-P262-P264-P270-P280-P302+P352+P310+P361+P364-P391-P405
Hazard Codes  N,T
Risk Statements  50/53-51/53-24
Safety Statements  60-61-45-36/37/39-28A
RIDADR  UN 3082 9/PG 3
WGK Germany  3
RTECS  XS8050000
HazardClass  6.1(b)
PackingGroup  III
HS Code  29329990
Toxicity LD50 orally in female, male rats: 6150, 7500 mg/kg (Gaines)

Piperonyl butoxide price More Price(14)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 291102 Piperonylbutoxide technical grade, 90% 51-03-6 100ml $48.1 2021-03-22 Buy
Sigma-Aldrich 45626 Piperonylbutoxide PESTANAL , analytical standard 51-03-6 100mg $50.7 2021-03-22 Buy
Sigma-Aldrich BP1171 Piperonylbutoxide British Pharmacopoeia (BP) Reference Standard 51-03-6 $220 2021-03-22 Buy
TCI Chemical P0458 Piperonyl Butoxide >90.0%(GC) 51-03-6 25g $18 2021-03-22 Buy
TCI Chemical P0458 Piperonyl Butoxide >90.0%(GC) 51-03-6 500g $124 2021-03-22 Buy

Piperonyl butoxide Chemical Properties,Uses,Production


Piperonyl butoxide (PBO) is a water insoluble colorless to pale yellow liquid that was developed in the 1940s to increase the effectiveness of various pesticides. It is currently registered as an active ingredient in more than 1500 products used for indoor or outdoor pesticides, including agricultural maintenance of some food crops.

Chemical Properties

Light Yellow Liquid


Piperonyl butoxide is used as a synergist for pyrethrins and their synthetic analogues.


Insecticide synergist, especially for pyrethroids and rotenone


PBO is a pesticide synergist. It is typically added to carbamate, pyrethrin, pyrethroid, and rotenone pesticides to greatly enhance their potency. PBO alone does not have pesticidal properties.

General Description

Pale yellow to light brown liquid with a mild odor and a faint bitter taste.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

Piperonyl butoxide can react with oxidizing materials.

Fire Hazard

Piperonyl butoxide is combustible.

Agricultural Uses

Insecticide synergist: A U.S. EPA restricted Use Pesticide (RUP). Not listed for use in EU countries. Piperonyl butoxide is a synergist, i.e., not a pesticide itself, but enhances the properties of other chemicals. It is used with other pesticides such as pyrethrins, pyrethroids, rotenone and carbamates in food and non-food agricultural products, home and garden products, termite and mosquito products, and veterinary pesticide products. It inhibits the insect’s ability to break down an insecticide before it takes effect, thereby prolonging the action, and reduces the necessity for using a stronger formulation.

Trade name

The U.S. EPA lists 7,340 products containing this substance, 1,622 of which are active

Safety Profile

Poison by skin contact. Moderately toxic by ingestion and intraperitoneal routes. An experimental teratogen. Experimental reproductive effects. Many glycol ether compounds have dangerous human reproductive effects, Questionable carcinogen with experimental tumorigenic data. Mutation data reported. Combustible when exposed to heat or flame; can react with oxidizing materials. To fight fire, use foam, CO2, dry chemical. When heated to decomDosition it emits PLATINOL 0 cis-PLATlNUM(II) DIAMMINE- DICHLORIDE

Environmental Fate

PBO is rapidly degraded (half-life 8 h) in the environment by photolysis and is metabolized by soil microorganisms. Its estimated atmospheric half-life is approximately 3 h.

Metabolic pathway

Piperonyl butoxide is used primarily in admixture with pyrethrins and some of the pyrethroids to enhance and prolong their insecticidal action. Much of this use is in domestic and industrial situations. Metabolism studies were conducted soon after its discovery and first use in the 1950s and 1960s. The main impetus initially was to understand the mode of action as a synergist. When this was shown to be due to the inhibition of oxidative metabolism, further studies were conducted to address possible toxic interactions with other pesticides and drugs in man.
Piperonyl butoxide undergoes rapid photodegradation and microbial degradation in soil. It is also rapidly metabolised in insects and mammals by oxidative attack at the methylenedioxy carbon atom and in the side chain. A comprehensive review by Casida (1970) describes the chemistry, mode of action and metabolism of piperonyl butoxide and several related methylenedioxyphenyl compounds. Though published nearly 30 years ago, the review remains a very useful compilation of a large amount of information, supported by more than 300 references.


Piperonyl butoxide is stable to hydrolysis at pH 5,7 and 9 in sterile buffers in the dark at 25 °C. It is rapidly degraded in aqueous solution at pH 7 in sunlight with a DT50 of 8.4 hours (PM). The compound was found to be relatively stable under a variety of irradiation conditions as a thin film on glass or in organic solvent (methanol, benzene and cyclohexane). Loss of the butoxyethoxy side chain was observed to give 5-methyl-6-propyl-l,3- benzodioxole (2), butoxyethanol (3) and ethanediol (4) (Fishbein and Gaibel, 1970). These studies did not utilise radiolabelled compound. The partial pathways are shown in Scheme 1.

Toxicity evaluation

As a synergist, PBO inhibits mixed-function oxidases, including cytochrome P450, and resistance-associated esterases that allow insects to degrade an insecticide, allowing enhanced insecticide efficacy. It does not effectively act as a synergist in mammals.

Piperonyl butoxide Preparation Products And Raw materials

Raw materials

Preparation Products

Piperonyl butoxide Suppliers

Global( 277)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Qingdao Trust Agri Chemical Co.,Ltd
13573296305 008613573296305
0532-87927000 CHINA 202 58
Capot Chemical Co.,Ltd.
+86(0)13336195806 +86-571-85586718
+86-571-85864795 China 20010 60
Henan DaKen Chemical CO.,LTD.
+86-371-66670886 China 21067 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693 CHINA 22607 55
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418684 18949823763
86-0551-65418684 China 3001 55
career henan chemical co
+86-371-86658258 CHINA 29968 58
Hubei Jusheng Technology Co.,Ltd.
027-59599243 CHINA 28229 58
Hebei Guanlang Biotechnology Co., Ltd.
+8619930503282 China 4940 58
Hubei xin bonus chemical co. LTD
027-59338440 CHINA 23035 58
Shandong chuangyingchemical Co., Ltd.
18853181302 CHINA 5917 58

View Lastest Price from Piperonyl butoxide manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-09-10 Piperonyl butoxide
US $3200.00 / KG 1KG 95% 100tons/month qingdao trust agri chemical co.,ltd
2021-08-26 PiperonylButoxide
US $10.60 / KG 1KG 95% 5000kg Hebei Crovell Biotech Co Ltd
2021-07-29 Piperonyl butoxide
US $5.00 / KG 1KG 99% 20 Tons Wuhan wingroup Pharmaceutical Co., Ltd

Piperonyl butoxide Spectrum

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